Research Progress in Cancer Prevention


Series: Cancer Etiology, Diagnosis and Treatments

Cancer has a complex etiology, probably due to a sophisticated interaction between the genetic endowment of individuals and environmental risk factors. The continuing magnitude and severity of cancer as a major health problem renders cancer prevention an important area in the field of cancer research. Developments in cancer prevention have benefitted from the recent advances in molecular and cellular biology. Several specific molecules have been identified as promising targets for cancer prevention and numerous agents have been synthesized, developed and tested to modulate the functions of these molecules. Given the ongoing advances in our understanding in the genesis of cancer, it is possible to develop new and better agents on a more mechanistic basis. The most striking examples for this mechanism-based approach for cancer prevention include: the role of inducible cyclooxygenase-2 (COX-2) in colon cancer and the preventive effects of COX-2 inhibitors (e.g., celecoxib); the involvement of estrogen receptors in breast cancer and the development of selective estrogen receptor modulators (e.g., tamoxifen and raloxifene) for the prevention of this malignancy; and the function of androgen in prostate cancer and the use of 5-á-reductase inhibitors (e.g., finasteride) as a preventive measure. This book provides leading edge research from around the globe on this field.

Table of Contents

Table of Contents


Stimulation of DNA Base Excision Repair in Cancer Prevention;pp. 1-13
(David Caldwell, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA, Mark R. Kelley, Department of Biochemistry and Molecular Biology and Pharmacology and Toxicology, Indiana University, School of Medicine, Indianapolis, IN, USA)

Dietary Compounds that Enhance DNA Repair and their Relevance to Cancer and Aging;pp. 15-30
(Harris Bernstein, Departments of Cell Biology and Anatomy, Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, Arizona, USA, Cheray Crowley-Skillicorn, Departments of Cell Biology and Anatomy, Carol Bernstein, Departments of Cell Biology and Anatomy, Section of Hematology/Oncology, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona, USA, et al.)

Environmental Tobacco Smoke Exposure and Respiratory Disease;pp. 31-73
(Chikako Kiyohara, Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Hiromasa Inoue, Yoichi Nakanishi, Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan)

Gender Differences in Lung Cancer;pp. 75-92
(Jong Y. Park, Tatyana Zhukov, Melvyn S. Tockman, Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, School of Medicine, University of South Florida, Tampa, Fl., USA)

Using Intervention Mapping in Program Development to Promote Cervical Cancer Screening Among Chinese Women: From Needs Assessment, Intervention Development, to Program Evaluation;pp. 93-137
(Su-I Hou, Department of Health Promotion and Behavior, College of Public Health, University of Georgia, Athens, GA, USA)

Preventing Cervical Cancer Worldwide;pp. 139-154
(Laurie Elit, Department of Obstetrics and Gynecology, McMaster University Juravinski Cancer Centre, Hamilton Health Sciences Centre, Hamilton, Ontario, Canada)

Malignancies in Systemic Lupus Erythematosus and Other Immunosuppressed States; Associations and Etiologic Mechanisms;pp. 155-208
(J. Patricia Dhar, Robert J. Sokol, Ann G. Schwartz,Wayne State University School of Medicine, Detroit, MI)

Cancers in Persons with Intellectual Disability: Current Data;pp.
(Daniel Satge, Centre Hospitalier, France, Bernard Azema, CREAI, France, Stephanie Culine, Centre Anticancéreux Val d’Aurelle, France Annie J. Sasco, INSERM, France)


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