Reprogramming of Somatic Cells

Stina Simonsson and Dzeneta Vizlin-Hodzic
University of Gothenburg, Sweden

Series: Cell Biology Research Progress
BISAC: SCI017000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Somatic cells can be reprogrammed and serve as genetic material to generate a new individual, embryonic stem cells (ESCs), or a cell type of another kind than the original somatic cell. Production of ESCs from the patient’s own somatic cells is an attractive supply in medicine, in particular as individual human model system for drug-screening, drug-design or toxicology testing, but could also be used in regenerative medicine. This book provides some background, molecular mechanisms and breakthroughs underlying reprogramming of somatic cells and discusses some of the obstacles to overcome. (Imprint: Nova Biomedical)

Abstract

Introduction

Human embryonic stem cells (hESCs)

Directed differentiation of hESCs

Gene Silencing during differentiation

Treatment of diseases with isogenic cells

Induced pluripotent stem cells (iPS cells)

Somatic Cell Nuclear Transfer (SNT)

History of Somatic Cell Nuclear Transfer (SCNT)

Final Remarks

Acknowledgments

References

Index

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