Renal Replacement Therapy: Controversies and Future Trends

José A. Moura-Neto, M.D.
CSB Group of Nephrology, Bahia, Brazil
Young Medical Leadership Program, National Academy of Medicine, Brazil

Series: Urology Research Progress
BISAC: MED088000

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Controversies and trends have been a constant presence in nephrology. Likewise, since its inception and throughout its development, renal replacement therapy has been shrouded in an atmosphere of uncertainty, always with an eye on the future.

Renal Replacement Therapy: Controversies and Future Trends is a collection of independent chapters written by eminent authors, focused on topics relevant to modalities of renal replacement therapy. This book addresses controversies and future trends in peritoneal dialysis, hemodialysis, and kidney transplantation. It covers issues from kidney patient education to new technologies in end stage renal disease management, including trends in arteriovenous access, convective therapies, the concept of incremental hemodialysis, fluid overload in hemodialysis and iron therapy. Regarding renal transplantation, it discusses a variety of subjects, highlighting xenotransplantation, organ bioengineering, immunosuppressive therapies, and living donor bioethics issues.

This book may appeal to nephrologists and physicians involved with renal replacement therapy and all those interested in the advances and challenges still facing medicine. It is, at the same time, a didactical textbook – providing valuable and updated medical information – and also represents the current thinking of great authors of our time on the subject. To a certain extent, it will also have historical value and may be considered a landmark of ideas in the field of nephrology.

Foreword by Claudio Ronco

Preface

Chapter 1. The Future of Renal Replacement Therapy in End Stage Kidney
Disease Patients
(Bernard Canaud, Ellen Busink, Katrin Koehler, Sudhir Bowry, and Christian Apel)

Chapter 2. Kidney Patient Education: Philosophy, Practice, and Resources
(Dori Schatell)

Chapter 3. Comprehensive Review of Iron Therapy in Chronic Kidney Disease
(Stephen Z. Fadem)

Chapter 4. When Dialysis is Not a Good Option; a Narrative Review of the Dilemma
of Renouncing Renal Replacement Therapy
(José A. Moura-Neto, Ana Flavia Moura, Daniela de Q. Moura, and José Hermógenes Rocco Suassuna)

Chapter 5. Modeling Dialysis: Understanding and Managing Physiologic Manipulation in ESRD
(John A. Sargent)

Chapter 6. Incremental Hemodialysis
(Kamonwan Tangvoraphonkchai and Andrew Davenport)

Chapter 7. Chronic Fluid Overload in Hemodialysis
(Fahad Aziz and Madhukar Misra)

Chapter 8. Future of AV Access: Novel Conduits and Strategies for Improving Maturation
(Dalila White, Philip L. Auyang, and Eric K. Peden)

Chapter 9. Hemodialysis frequency: It is time to change the prescription
(Nathalia P. Paschoalin Carvalho, Túlio Coelho Carvalho, and Raphael P. Paschoalin)

Chapter 10. Convective Therapies in the Treatment of CKD Stage 5 Patients: to Be or Not to Be Convincing
(José Carolino Divino-Filho and Ikuto Masakane)

Chapter 11. Controversies and Future Trends in Peritoneal Dialysis
(Vanessa Burgugi Banin, Dayana Bitencourt Dias, Jacqueline Teixeira Caramori, Pasqual Barretti, and Daniela Ponce)

Chapter 12. Peritoneal Dialysis Therapy in the Acute Kidney Injury Setting: Back to the Future
(José Carolino Divino-Filho)

Chapter 13. We Need to Talk about Living Kidney Donation
(José A. Moura-Neto, Ana Flavia Moura, and Edison Souza)

Chapter 14. Immunosuppressive Therapies after Kidney Transplantation: the Old Challenges of New Strategies
(Lucía Alejandra Alfaro Villanueva, Juliana Busato Mansur Siliano, Laila Almeida Viana, Marina Pontello Cristelli, Patricia Cristina Grenzi, Helio Tedesco-Silva Junior, José Osmar Medina-Pestana, and Claudia Rosso Felipe)

Chapter 15. The Future of Renal Transplantation
(Matthew L. Holzner, Nandita Singh, and Ron Shapiro)

Chapter 16. Contrast Enhanced Ultrasonography: from Native Kidneys to Allografts
(Ana Flavia Moura, José A. Moura-Neto, and Nordeval C. Araujo)

Chapter 17. Rare Renal Diseases and Renal Replacement Therapy: What We Know Now
(Cassiano Augusto Braga Silva, Fellype de Carvalho Barreto, Maria Helena Vaisbich, and Osvaldo Merege Vieira Neto)

Chapter 18. Obesity and Renal Replacement Therapy
(Jorge Luiz de Carvalho Henriques Junior and Joan Araujo Oliveira Moitinho)

Chapter 19. Nephro-geriatrics
(Carmen Tzanno-Martins and Cassia Gomes S. Santos)

Chapter 20. The History and Future of cyberNephrology and Relationship to the Banff Classification
(Kim Solez, Assel Rakhmetova, Nikhil Shah, Lekhini Bhatt, Ishita Moghe, and James Burdick)

“As a specialist, I always want to know what is the state of the art. But I also want to know where the future lies, and to be aware of the controversies and potential solutions. I am therefore delighted to recommend this book that provides insight into the ongoing challenges and the future of renal replacement therapies.” - Richard J Johnson, MD. A Founding Editor of Comprehensive Clinical Nephrology, Elsevier

“‘Renal Replacement Therapy - Controversies and Future Trends’ is a must read for all nephrologists and those in training. Outstanding authors take a unique look at current practice, opportunities to improve care, and the potential for the care for kidney patients. Not as much a textbook as a roadmap to the future!” - Allen R. Nissenson, MD, FACP. Emeritus Professor of Medicine, David Geffen School of Medicine at UCLA and Chief Medical Officer, DaVita Kidney Care

"Medicine is always looking for evidence derived from research and is often inspired by controversies. As well as being a very worthwhile read, this book acts as a delightful guide to the current practice of renal replacement therapy. It merits particular consideration for uniquely highlighting the underlying challenges and controversies in the field, in addition to the potential solutions created by innovative technologies for more carefully and individually tailored care for kidney patients. I wholeheartedly recommend this as required reading for both senior and, particularly, young nephrologists". - Giuseppe Remuzzi, MD, FRCP. Research Coordinator, IRCCS - Mario Negri Institute for Pharmacological Research

Keywords: Hemodialysis; Peritoneal Dialysis; Dialysis; Renal Transplantation; Kidney Transplantation; Nephrology; Kidney; Renal Replacement Therapy

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