Regulation of Vitamin A Homeostasis by the Stellate Cell (Vitamin A-Storing Cell) System

Haruki Senoo
Akita University School of Medicine, Akita-City, Akita, Japan

Series: Nutrition and Diet Research Progress, Cell Biology Research Progress
BISAC: SCI017000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Vitamin A-storing cells in the liver exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule, and store 50-80% of vitamin A in the whole body as retinyl palmitate in lipid droplets in the cytoplasm. In physiological conditions, these cells play pivotal roles in the regulation of vitamin A homeostasis. In pathological conditions such as hepatic fibrosis or liver cirrhosis, hepatic stellate cells lose vitamin A, and synthesize a large amount of extracellular matrix components including collagen, proteoglycan, glycosaminoglycan, and adhesive glycoproteins. Morphology of these cells also changes from the star-shaped stellate cells to that of fibroblasts or myofibroblasts. This book discusses and presents research on vitamin A-storing cells.

(Imprint: Nova Biomedical)

1. INTRODUCTION

2. NUCLEAR RECEPTORS

3. INVOLVEMENT IN HEPATIC DISEASES

4. STAP/CTYOGLOBIN EXPRESSION IN HSCS

5. DEVELOPMENT (ONTOGENY AND PHYLOGENY)

6. AGEING

7. IMMUNITY AND HSCS

CONCLUSIONS

INDEX

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