Regulation of Neutrophil Hemeostasis by Spontaneous Apoptotic Death

Hongbo R. Luo (Editor)
Besnik Bajrami (Editor)
Harvard Medical School, Boston, Massachusetts, USA, and others

Series: Immunology and Immune System Disorders
BISAC: MED044000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Neutrophils are terminally differentiated and normally have a very short life-span (7-20 hr) in circulation and in tissue (1-4 days). Neutrophil death is a critical mechanism for modulating neutrophil homeostasis. Accelerated neutrophil death leads to a decrease of neutrophil counts (neutropenia), augments the chance of contracting bacterial or fungal infections, and impairs the resolution of such infections. On the other hand, delayed death and clearance of neutrophils in tissues cause unwanted and exaggerated inflammation.

Thus, the death program in neutrophils needs to be well controlled to provide a perfect balance between their immune functions and their safe clearance. This book discusses recent studies on the molecular mechanism of neutrophil spontaneous death. Intracellular factors and extracellular stimuli that can modulate neutrophil lifespan as well as the involvement of neutrophil apoptosis in infectious and inflammatory diseases are also discussed. (Imprint: Nova Biomedical)

ABSTRACT

NEUTROPHILS ARE MAJOR PLAYERS IN INNATE IMMUNE SYSTEM

NEUTROPHIL HOMEOSTASIS

NEUTROPHIL DEATH AS A MAJOR MECHANISM FOR MODULATING NEUTROPHIL HOMEOSTASIS

NEUTROPHIL DEATH CAN BE ACCELERATED OR DELAYED

CELLULAR AND MOLECULAR MECHANISM OF NEUTROPHIL DEATH

NEUTROPHIL DEATH IN INFLAMMATORY AND IMMUNOLOGICAL DISEASES

CONCLUSION

REFERENCES

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