Regucalcin: Metabolic Regulation and Disease

Masayoshi Yamaguchi, PhD (Editor)
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), California, USA

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000

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Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This book, which is entitled “Regucalcin: Metabolic Regulation and Disease”, introduces the recent topics regarding the involvement of regucalcin in metabolic regulation and its related diseases. Cell signaling system may be potent interest in the fields of biomedical research. Regucalcin, which was discovered as a calcium-binding protein in 1978, is demonstrated to play a potential role as a suppressor in manifold intracellular signaling process linked to transcription activity.

With growing studies, regucalcin has been demonstrated to play a multifunctional role in the regulation of the function of various types of cells and tissues, including the regulation of intracellular calcium homeostasis, various enzymes activity, cell signal transduction, nuclear function and gene expression, cell proliferation, apoptosis, and other cellular events. Regucalcin plays a pivotal role in maintaining cell homeostasis and protecting from disorders with ageing. This book focuses recent highlighted information regarding the role of regucalcin in metabolic regulation and its related diseases with aging. This book is constituted of 6 chapters as described in the following. This book will be of interest to graduate students, researchers, scientists and physicians focused on the fields of molecular and cellular biology, biomedical sciences, and clinical challenges.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Structure of Regucalcin Gene and Protein
(Noriaki Shimokawa, Department of Nutrition, Takasaki University of Health and Welfare, Gunma, Japan)

Chapter 2. The Horizons of Regucalcin in Male Reproduction
(Sara Correia, Harikrishna Pillai, Ana Manuela S. Silva, Vanessa M. Santos and Silvia Socorro, CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal, and others)

Chapter 3. Regucalcin: A Tumor-Associated Antigen and a Tumor-Suppressing Molecule
(Su-Fang Zhou, Department of Biochemistry and Molecular Biology, Guangxi Medical University, Nanning, Guangxi, China)

Chapter 4. The Role of Regucalcin in Bone Remodeling and Osteoporosis
(Masayoshi Yamaguchi, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, US)

Chapter 5. Involvement of Regucalcin in Diabetes and Hyperlipedemia
(Masayoshi Yamaguchi, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, US)

Chapter 6. Extracellular Vesicles: A Conversation in the Body
(Naoomi Tominaga, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, US)

Index

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