Rectal Cancer: Etiology, Pathogenesis and Treatment


Paula Wells (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

Current controversies about rectal cancer treatment are examined and discussed in this book. In particular, oncologic outcomes, which claim an aggressive approach over the primary tumor, lymph nodes and distant metastasis. Also, the functional outcome, whose important objective is to preserve the anal sphincter and the preservation of the pelvic nervous plexus.Radical resection with total mesorectal excision is the mainstay of rectal cancer treatment. However, it is associated with significant surgical morbidity/mortality, possible stoma surgery/complications and long-term gastrointestinal dysfunction with deterioration in quality of life.This book also explores the risk factors of local recurrence after curative resection in patients with middle and lower rectal carcinoma. The relationships between mesorectal metastasis and local recurrence and the possible correlations between circumferential resection margin status and local recurrence were identified. The relationships between local recurrence and clinicopathologic characteristics of middle and lower rectal carcinoma were also evaluated.

Table of Contents


Research and Review Studies

Surgical Treatment of Rectal Cancer-Current Controversies;pp. 1-39
(Vilcea I.D, Vasile I., IInd Surgical Clinic, Emergency Hospital of Craiova, Romania)

The Effect of Adjuvant Therapy on Surgical Treatment of Rectal Cancer;pp. 41-64
(Luca Stocchi, Victor W. Fazio, Department of Colorectal Surgery
Digestive Disease Institute, Cleveland Clinic, Cleveland, OH)

Three Dimensional Endorectal Ultrasonography in Rectal Cancer Staging;pp. 65-93““““““““
(G.A. Santoro, L. Cancian, Regional Hospital, Treviso, Italy,
S. Magrini,Veneto Hospital, Vittorio, Veneto, Italy)

Transanal Endoscopic Microsurgery (TEM) in Early Rectal Cancer;pp. 95-112
(A. Suppiah, J.R.T. Monson, Academic Surgical Unit, Castle Hill Hospital, United Kingdom)

Staging and Treatment of Early Rectal Cancer;pp. 113-143
(Baatrup, G and Pfeiffer, P, Surgical Clinic, Section of Colorectal Surgery, Haukeland University Hospital, Bergen, Norway, and others)

Transanal Endoscopic Microsurgery of Rectal Tumor: A Review;pp. 145-158
(Damian Casadesus, Hospital Calixto Garcia, J and Univ., Havana, Cuba)

*Correlation between Metabolic Enzymes of Nucleic Acid in Colorectal Cancer Patients and FRNA/TSIR, Prognostic Factors;pp. 159-171
(Kenji Katsumata, Tetsuo Sumi, Daisuke Matsuda, et al., Department of Surgery, Tokyo Medical University)

*Germline and Somatic Mutations in Colorectal Cancers from Patients with Hereditary Nonpolyposis Colorectal Cancer;pp. 173-190
(Michiko Miyaki Tatsuro Yamaguchi,Takeo Mori, Tokyo Metropolitan Komagome Hospital, Japan)

*Women and Colorectal Cancer;pp. 191-209
(Samantha Hendren, Dept. of Surgery, University of Rochester,USA)209

Dietary Fatty Acids and Acyl-CoA Synthetases in the Modifier Concept of Colorectal Carcinogenesis;pp. 211-222
(Nikolaus Gassler,Christina Klaus, Andrea Reinartz,Institute of Pathology, RWTH Aachen University, Germany, Elke Kaemmerer, Dept. of Pediatrics,RWTH Aachen University ,Germany, Andrea Reinartz, School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta,USA

Short Communications

Risk Factor of Local Recurrence after Curative Resection in Patients with Middle and Lower rectal Carcinoma;pp. 223-231
(Wu Ze-yu, Wan Jin, Zhao Gang, Peng Lin, Du Jia-lin, Yao Yuan, Liu Quan-fang, Wang Zhi-du, Huang Zhi-ming, Dept. of General Surgery, Guangdong Provincial Peoples Hospital, Guangdong Province, China, Lin Hua-Huan, Dept. of Pathology, Guangdong Provincial Peoples Hospital, Guangdong Province, China)

CT-Guided Interstitial Brachytherapy as an Innovative Adjunct to Current Therapeutic Strategies in the Treatment of Colorectal Liver Metastases;pp. 233-240
(Christain Grieser, Dirk Schnapauff, Timm Denecke, Klinik Fur Strahlenheilkunde, Campus Virchow-Klinikum, Charite-Univ. Berlin, Berlin, Germany)


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