Recent Advances in Systems Biology Research


André X. C. N. Valente (Editor)
Center for Neuroscience and Cell Biology, Systems Biology Group, University of Coimbra, Biocant – Biotechnology Innovation Center, Cantanhede, Portugal

Abhijit Sarkar (Editor)
Department of Physics and Vitreous State Laboratory, Catholic University of America, Washington DC, USA

Yuan Gao, MD (Editor)
Lieber Institute for Brain Development, John Hopkins Medical Campus, Baltimore

Series: Systems Biology – Theory, Techniques and Applications
BISAC: SCI008000

Driven by rapid developments in protein and DNA sequencing technologies, systems biology has become an important research paradigm. It is marked by an emphasis on integrating data on multiple scales and on creating a framework for developing predictive models that are valid across the spectrum of structural hierarchies found in biological systems.

This book consists of fourteen original chapters that together provide a comprehensive introduction to the subject starting from discussions of its definition and scope and ending in detailed reviews of how the systems approach is affecting clinical research and practice. Most chapters are written to be accessible to a wide readership and contain references to the latest research. Altogether, this is a state-of-the-art description of the present and future of systems biology. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents



Chapter 1. The Conceptual Foundations of Systems Biology: An Introduction
(Mariano Bizzarri, Alessandra Cucina and Alessandro Palombo, University of Rome, Rome, Italy)

Chapter 2. The Mesoscopic Level and its Epistemological Relevance in Systems Biology
(Marta Bertolaso, Alessandro Giuliani and Simonetta Filippi, Institute of Philosophy of Scientific and Technological Practice, Faculty of Engineering, University Campus Bio-Medico of Rome, Italy
and others)

Chapter 3. Mathematical Framework for Analyzing Genome-Wide Association Study Data with Rational Classes
(André X. C. N. Valente, Abhijit Sarkar, Joo Heon Shin, Jie Wu and Yuan Gao, Center for Neuroscience and Cell Biology, University of Coimbra and Biocant – Biotechnology Innovation Center, Portugal and others)

Chapter 4. A Review and Perspective on Thermodynamics Applied to Molecular Systems and Cancer Biology
(Edward A. Rietman, Philip Hahnfeldt and Lynn Hlatky, Center of Cancer Systems Biology, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA)

Chapter 5. Analysis of Protein-Protein Interaction Networks for Identification of Functional Modules
(Tolga Can, Department of Computer Engineering, Middle East Technical University, Ankara, Turkey)

Chapter 6. Mass Spectrometry in Systems Biology
(Lei Cheng, Robert A. Fenton, Trairak Pisitkun, Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport, Aarhus University, Denmark and others)

Chapter 7. Theory of Reliability in Systems Biology: Aging versus Reliability
(Vitaly K. Koltover, Bio-Reliability Group, Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia)

Chapter 8. Computational Approaches in Synthetic and Systems Biology
(Miha Moskon, Jure Bordon, Miha Mraz, Nikolaj Zimic and Mattia Petroni, Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia)

Chapter 9. Modelling Transcriptional Regulation with Gaussian Processes
(Vinny Davies and Dirk Husmeier, School of Mathematics and Statistics
University of Glasgow, United Kingdom)

Chapter 10. Cancer Systems Biology
(Rachael Hageman Blair, David L. Tritchler and Daniel P. Gaile, Department of Biostatistics, State University of New York at Buffalo, Buffalo, New York, USA and others)

Chapter 11. Systems Biology Approach for Human Complexity and Personalized Cardiology
(George E. Louridas and Katerina G. Louridas, Thessaloniki, Greece)

Chapter 12. Football, Airplanes, Diabetes and Systems Biology
(Alexandra R. Petrasek and Danny Petrasek, Tulane University, New Orleans, Louisiana, USA and others)

Chapter 13. Cardiac Systems Biology
(Seong-Eui Hong, Hong Ki Song, Taeyong Kim, Pradeep Kumar Sreenivasaiah, and Do Han Kim, School of Life Sciences and Systems Biology Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea)

Chapter 14. Systems Biology Approach to Transplant Immune Tolerance
(Reza F. Saidi and S. Kamran Hejazii Kenari, Division of Organ Transplantation, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA)



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