Recent Advances in Drug Delivery Research


Valerio Voliani, PhD (Editor)
Scuola Normale Superiore and Istituto Nanoscienze-CNR Center for Nanotechnology Innovation @ NEST, Istituto Italiano di Tecnologia, Pisa, Italy

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED058170

It has been over 100 years since Dr. Paul Ehrlich referred to an ideal therapeutic agent able to target and treat only a highly specific site in an organism in 1906: the so-called “magic bullet.” The birth of new technologies, such as nanostructures, combined with the improved knowledge on the physiology and the biochemistry at the basis of human behavior have opened completely new trails in medicine, making the research over drug delivery one of the most vital fields of science.

This book presents a timely and informative summary of the current progress in a variety of subject areas, including medicine, chemistry and biology. This book is written by experts in the field and serves as an indispensable reference to advanced researchers. The last advances in drug delivery, including nanoparticles, conjugated polyphenol, enhanced permeability and retention effect, and also chimeric nanosystems, are addressed and provided by extensive and recent literature. (Imprint: Nova Biomedical )



Table of Contents

Preface pp.vii-viii

Chapter 1. Enhanced Permeability and Retention Effect: Insights Impacting Nanoscale Drug Delivery Systems
(S. Neslihan Alpay, Jim Klostergaard, Departments of Experimental Therapeutics and Molecular and Cellular Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA)pp.1-32

Chapter 2. Recent Advances in Oral Drug Delivery Systems
(Tolulope O. Ajala, Olufunke D. Akin-Ajani, Oluwatoyin A. Odeku, Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Nigeria)pp.33-50

Chapter 3. Recent Progress in pH-Sensitive Nanocarriers for an Efficient Delivery of Biomolecules to Specific Targets
(Daniele R. Nogueira, Montserrat Mitjans and M. Pilar Vinardell, Department de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain)pp.51-72

Chapter 4. Bio-Inspired Chimeric Drug Delivery Nanosystems (chi-DDnSs): Their Fractal Morphology and Regulatory Aspects
(Natassa Pippa, Stergios Pispas, Costas Demetzos, Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece, and others)pp.73-96

Chapter 5. In Situ Gelling Systems for Sustained Drug Delivery
(Lívia Neves Borgheti-Cardoso, Fabiana Testa Moura de Carvalho Vicentini, Tais Gratieri and Maria Vitória Lopes Badra Bentley, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, SP, Brazil, and others)pp.97-126

Chapter 6. Solid Lipid Nanoparticles Prepared by the Phase Inversion Temperature Method as Carriers for Idebenone
(M.G. Sarpietro, M.L. Accolla, G. Puglisi, F. Castelli and L. Montenegro, Dipartimento di Scienze del Farmaco, Università di Catania, Catania, Italy, and others)pp.127-148

Chapter 7. Polyphenol Conjugate: Synthesis and Potential Biomedical Applications
(O.Vittorio, G. Cirillo, S. Hampel, F. Iemma and M. Kavallaris, Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia and others)pp.149-166

Chapter 8. Targeting Drug Delivery Systems: Promises, Promises, and More Promises…Let’s Change the Paradigm
(Karel Petrak, Vice President for Strategic Grants Development, Harris Health System, Houston, Texas, USA)pp.167-180

Index pp.183-196

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