Pyrazole: Preparation and Uses

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Dilipkumar Pal (Editor)
Associate Professor, Department of Pharmaceutical Sciences, GURU GHASIDASH VISHWAVIDYALAYA (A Central University), Koni, Bilashpur, India

Series: Chemistry Research and Applications
BISAC: SCI013040

This book has comprehensively reviewed the latest information on pyrazoles, their preparations and uses. It provides extended ideas on pyrazole and its derivatives including their synthesis, chemistry, structure activity relationship (SAR) and therapeutic applications. The health promoting properties of these pyrazoles are discussed in this book with different therapeutic applications of pyrazole scaffold. Topics related to pyrazole and its analogues as potential anticancer, anti-angiogenesis, antiviral, antioxidative, anti-convulsive, anthelmintic, anti-inflammatory, antidiabetic agents are described in this book in detail.

Furthermore, current status and future prospects of pyrazole moiety in drug discovery, importance of it in plant systems, its relevance in neurological drug discovery, its potency as herbicidal and antimicrobial agents have been enumerated through different chapters. In a summary, this book is a valuable resource for research scholars, academics, students, industrialists and subject experts working in the multidisciplinary fields like medicinal chemistry, synthetic chemistry, biochemistry, pharmacology, natural product chemistry and other related areas in the field of pyrazole derivatives drug discovery and research.

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Table of Contents

Dedication

Preface

Chapter 1. Current Status of Pyrazolo Moiety in Drug Discovery (Synthetic vs. Natural)
(Chandi Charan Kandar and Dilipkumar Pal, Department of Pharmaceutical Chemistry, Institute of Pharmacy, Jalpaiguri, Government of West Bengal, West Bengal, India, and others)

Chapter 2. Synthesis and Therapeutic Applications of Pyrazole Scaffold
(Roli Mishra and Satyendra Mishra, Department of Physical Sciences, Institute of Advanced Research, Gandhinagar, India)

Chapter 3. Pyrazole Based Ligands: Versatile Building Blocks
(Preeti Oswal, Aayushi Arora, Gyandshwar Kumar Rao, Sushil Kumar, Arun Kumar and Ajai Kumar Singh, Department of Chemistry, School of Physical Sciences, Doon University, Dehradun, Uttarakhand, India, and others)

Chapter 4. Pyrazole and Its Analogues as Potential Anti-Angiogenesis Agents
(Dilipkumar Pal and Souvik Mukherjee, Department of Pharmaceutical Sciences, Guru Ghasidas Viswavidyalaya [A Central University], Bilaspur, Chhattisgarh, India)

Chapter 5. Green Chemistry Methods in Pyrazole Synthesis
(Maja Molnar and Mario Komar, Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Croatia)

Chapter 6. Pyrazoles as Antiviral Agents
(Jeanne Fichez and Patricia Busca, LCBPT, UMR CNRS 8601, Université de Paris, Paris, France)

Chapter 7. Recent Research Advances in Aqueous Phase Synthesis of Pyrazoles
(Venkata Durga Nageswar Yadavalli, Nelson L. C. Domingues, Ramesh Katla and Rakhi Katla, Organic Catalysis and Biocatalysis Laboratory-OCBL/ FACET, Federal University of Grande Dourados—UFGD, Dourados, MS, Brazil)

Chapter 8. Pyrazole Moiety as a Source of Natural Products
(Dilipkumar Pal, Souvik Mukherjee, Om Prakash Panda, Sitansu Sekhar Nanda and Dong Kee Yi. Department of Pharmaceutical Sciences, Guru Ghasidas Viswavidyalaya [A Central University], Bilaspur, Chhattisgarh, India, and others)

Chapter 9. Pyrazole and Its Derivatives, Preparation, SAR and Uses as Antioxidative Agent
(Supriyo Saha and Dilipkumar Pal, School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Dehradun, Uttarakhand, India, and others)

Chapter 10. Role of Pyrazole Ring in Neurological Drug Discovery
(Supriyo Saha and Dilipkumar Pal, School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Dehradun, Uttarakhand, India, and others)

Chapter 11. Pyrano[2,3-c]pyrazole Derivatives: Synthesis and Applications
(Devendra Dewangan, Trimurti L. Lambat, Sami H. Mahmood and Subhash Banerjee, Department of Chemistry, Guru Ghasidas University, Koni, Bilaspur, Chhattisgarh, India, and others)

Chapter 12. Pyrazole and Pyrazole Derivatives: A Versatile Platform in Anti-Convulsive Drug Discovery
(Dilipkumar Pal, Suvadeep Mal and Souvik Mukherjee, Department of Pharmaceutical Sciences, Guru Ghasidas Viswavidyalaya [A Central University], Bilaspur, Chhattisgarh, India, and others)

Chapter 13. Pyrazole Affixed Heterocycles: Synthesis and Their Herbicidal Activity
(Shridevi Doddamani and Srikantamurthy Ningaiah, Chemical Sciences and Technology Division, CSIR-NIIST, Trivandrum, Kerala, India, and others)

Chapter 14. Development in Chemistry and Synthesis of Pyrazole Derivatives as Potential Anticancer Agents
(Ashish D. Patel, Vinod Kumar Gurjar and Dilipkumar Pal, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India, and others)

Chapter 15. Recent Advances in Chemistry and Synthesis of Pyrazole Derivatives as Potential Promising Antimicrobial Agents
(Vinod Kumar Gurjar, Dilipkumar Pal and Ashish D. Patel, School of Pharmacy, Parul University, P. O. Limda, Vadodara, Gujarat, India, and others)

Chapter 16. Scaffold of Pyrazole Derivatives for Enzyme Inhibition
(Neetu Sachan, Phool Chandra and Dilipkumar Pal, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India, and others)

Chapter 17. Role of Pyrazolo Ring in Plant System
(Chandi Charan Kandar, Department of Pharmaceutical Chemistry, Institute of Pharmacy, Jalpaiguri, Government of West Bengal, West Bengal, India)

Chapter 18. Pyrazole and Its Derivatives: Preparation, SAR and Anthelmintic Activity
(Arindam Maity, School of Pharmaceutical Technology, Adamas University, Kolkata, West Bengal, India)

Chapter 19. Pyrazole and Its Derivatives, Preparation, SAR and Anti-Inflammatory Activity
(Kiran Gangarapu1 Gouthami Thumma, Niveditha Nakka, Krishna Prasad Devarakonda, Dilipkumar Pal and Arivarasan Vishnu Kirthi, Department of Pharmaceutical Analysis, School of Pharmacy, Anurag Group of Institutions, Hyderabad, Telangana, India, and others)

Chapter 20. Pyrazole and Its Derivatives as Anti-Diabetic Agents
(Dilipkumar Paland Khushboo Raj, Department of Pharmaceutical Sciences, Guru GhasidasVishwavidyalaya, [A Central University], Koni, Bilaspur, India)

Chapter 21. Future Prospects of Pyrazole Ring in Drug Discovery
(Sajal Kumar Jha and Tanmoy Guria, School of Pharmaceutical Technology, Adamas University, Kolkata, India)

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