Pulmonary Vascular Disorders

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Roberto G. Carbone, MD, FCCP (Editor) – Consultant Cardio-Pulmonary Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
Francesco Puppo, MD (Editor) – Professor of Internal Medicine and Clinical Immunology, Department of Internal Medicine, University of Genoa, Genoa, Italy
Victor F. Tapson, MD, FCCP, FRCP (Editor) – Professor of Medicine, Department of Medicine, Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Series: Pulmonary and Respiratory Diseases and Disorders

BISAC: MED079000

Pulmonary vascular disorders are a complex and fascinating group of diseases. The aim of this book is to exhaustively review the genetics, physiology, diagnosis, management, and treatment of pulmonary vascular disorders with the purpose of helping general physicians and specialists in internal medicine, cardiology, pneumology, immunology, rheumatology, and hematology to identify and assess patients with vascular pulmonary disorders. Special emphasis has been placed upon pulmonary hypertension, pulmonary fibrosis, and pulmonary embolism as well as on pulmonary vascular involvement in immune-mediated diseases, chronic obstructive and advanced pulmonary disease, and sleep apnea. Additional topics that are covered in this book include pulmonary vascular injury occurring in alpha-1 antitrypsin deficiency, congenital heart disease and pregnancy. The text is supported by figures and tables to help the reader understand mechanisms of pulmonary vascular disorders in different clinical settings.

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Preface

Part I. General Principles

Chapter 1. The Genetic Basis of Pulmonary Arterial Hypertension
(Emilia M. Swietli, MD and Nicholas W. Morrell, MD – Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, Biomedical Campus, Cambridge, UK)

Chapter 2. Physiology Related to Pulmonary Vascular Disorders: An Overview
(Roberto G. Carbone, MD and Francesco Puppo, MD – Department of Internal Medicine, University of Genoa, Genoa, Italy)

Chapter 3. Immunology in Pulmonary Vascular Disorders: Focus on Pulmonary Arterial Hypertension
(Frédéric Perros, MD, Florent Soubrier, MD, Fabrice Antigny, MD, Rozenn Quarck, MD, Marc Humbert, PhD, David Montani, MD and Sylvia Cohen-Kaminsky, MD – Université Paris-Saclay, AP-HP, INSERM UMR_S 999, Service de Pneumologie et Soins Intensif Respiratoires, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France, et al.)

Chapter 4. Pathology in Pulmonary Vascular Disorders: The Past, Present, and Future
(Rubin M. Tuder, MD – Program in Translational Lung Research Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, CO, USA)

Chapter 5. Imaging of Pulmonary Hypertension
(Erica Altschul, MD, Priti Mehla, MD, Stephen Machnicki, MD, Roxanne Sulica, MD, Varun Shah, MD, Nick Hill, MD and Suhail Raoof, MD – Lung Center, Lenox Hill Hospital, Western Region Pulmonary Service, Northwell Health, New York, NY, USA, et al.)

Part II. Cardiopulmonary Diseases

Chapter 6. Diagnosis of Idiopathic Pulmonary Arterial Hypertension
(Benjamin Nguyen, MBBS, Marc Humbert, PhD and Edmund M. Lau, PhD – Royal Alfred Hospital, University of Sydney, Australia, et al.)

Chapter 7. Pulmonary Vascular Involvement in Idiopathic Pulmonary Fibrosis
(Mada Ghanem, MD and Bruno Crestani, MD – Université de Paris, Inserm, U1152, Service de Pneumologie A, Hôpital Bichat, Paris, France)

Chapter 8. Vascular Injury in Chronic Obstructive Pulmonary Disease
(Isabel Blanco, MD and Joan A. Barberà, MD – Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain)

Chapter 9. Pulmonary Hypertension in Obstructive Sleep Apnea and Interstitial Lung Disease
(Yang Zhou, MD, Katherine E. Cox-Flaherty, MD and James R. Klinger, MD – Brown University Department of Molecular Microbiology and Immunology, et al.)

Chapter 10. Pulmonary Vascular Complications in Congenital Heart Diseases
(Julie Wacker, MD and Maurice Beghetti, MD – Pediatric Cardiology Unit, University Children’s Hospital HUG, Pulmonary Hypertension Program HUG, Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque Pédiatrique (CURCCCP), University of Geneva and Lausanne, Geneva and Lausanne, Switzerland)

Chapter 11. Cor Pulmonale in 2020
(Robert Naeije, MD – Department of Pathophysiology, Université Libre de Bruxelles, Bruxelles, Belgium)

Chapter 12. Diagnosis and Management of Acute Pulmonary Embolism
(Michael McMahon, MD, Shari Barnett Brosnahan, MD and Lisa K. Moores, MD – Department of Medicine, Tripler Army Medical Center, Honolulu, HI, USA, et al.)

Chapter 13. Chronic Thromboembolic Pulmonary Hypertension: Causes, Diagnosis, and Therapy
(Estefania Oliveros, MD, Victor F. Tapson, MD and William Auger, MD – Department of Medicine; Temple University Hospital, Philadelphia, PA, USA, et al.)

Chapter 14. Acute Pulmonary Embolism: Classification, Risk Stratification and Critical Aspects of Therapy
(Victor F. Tapson, MD – Division of Pulmonary and Critical Care, U.S. Pulmonary Embolism Consortium, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

Chapter 15. New Drugs in Idiopathic Pulmonary Arterial Hypertension
(Robert N. Channick, MD – Pulmonary and Critical Care Division, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA)

Part III. Systemic Diseases

Chapter 16. Sarcoidosis Associated Pulmonary Hypertension
(Robert P. Baughman, MD and Elyse E. Lower, MD – Department of Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA)

Chapter 17. Pulmonary Vasculitis in ANCA-associated and Goodpasture’s Disease
(Kathryn A. Lai, MD and Namita Sood, MD – McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA, et al.)

Chapter 18. Pulmonary Hypertension in Rheumatoid Arthritis
(Joshua J. Solomon, MD, Roberto G. Carbone, MD and Francesco Puppo, MD – Autoimmune Lung Center, National Jewish Health, Denver, CO, USA, et al.)

Chapter 19. Pulmonary Vascular Injury in Systemic Sclerosis: Diagnosis and Treatment
(Francesco Puppo, MD, Simone Negrini, PhD, and Roberto G. Carbone, MD – Department of Internal Medicine, University of Genoa, Genoa, Italy)

Chapter 20. Lung Involvement in Systemic Lupus Erythematosus and Disseminated Intravascular Coagulation
(Assaf Monselise, PhD, Roberto G. Carbone, MD and Francesco Puppo – Department of Internal Medicine, Tel Aviv University, Israel, et al.)

Chapter 21. Other Causes of Disseminated Intravascular Coagulation
(Keith C. Meyer, MD – UW Lung Transplant & Advanced Pulmonary Disease Program, Section of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health)

Chapter 22. Pulmonary Vascular Disorders and Alpha-1 Antitrypsin Deficiency
(Roberto G. Carbone, MD and Giovanni Bottino, MD – Department of Internal Medicine, University of Genoa, Genoa, Italy)

Chapter 23. Pulmonary Hypertension in Pregnancy
(Christine Y. Zhou, DO, Ralph J. Panos, MD and Jean M. Elwing, MD – Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA, et al.)

Part IV. Advanced Lung Diseases

Chapter 24. Pulmonary Vascular Disease and Transplant in Advanced Lung Diseases
(Peter Yau, MD, Tasnim Lat, DO, Oksana Shlobin, MD, Adriel Malave, MD and Deborah J. Levine, MD – Texas A&M Health Sciences Center, Division of Pulmonary, Critical Care & Sleep Medicine, Baylor Scott & White Health Temple, TX, USA, et al.)

Index

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