Pulmonary Embolism: Contemporary Diagnosis, Risk Stratification and Management

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Irena Mitevska, MD, PhD – Associate Professor, Vice President of the National Society of Cardiology of North Macedonia, Intensive Care Unit, University Cardiological Clinic, Skopje, North Macedonia
Sonja Salinger, MD, PhD – Associate Professor of Cardiology, Cardiology Clinic, Clinical Center of Nis, Serbia
Marijan Bosevski, PhD – Professor, University Cardiology Clinic, St. Cyril and Methodius University, Faculty of Medicine, Skopje, N. Macedonia
Elizbeta Srbinovska, PhD – Professor, University Cardiology Clinic, Clinical Center, Medical Faculty, University “St Cyril and Metodij”, Skopje, North Macedonia
Slobodan Obradovic, PhD – Professor, Clinic of Cardiology, Military Medical Academy School of Medicine University of Defense Belgrade, Serbia

Series: Cardiology Research and Clinical Developments
BISAC: MED010000; MED019000; MED079000
DOI: https://doi.org/10.52305/LSSW3628

Acute pulmonary embolism is an emergency diagnosis and major cause of vascular death. It also presents one of the most missed diagnosis with heterogenous clinical presentation. The individual patient and health care burden of pulmonary embolism is increased in the era of increased prevalence of cancer associated pulmonary embolism, high risk pregnancy, underline thrombophilia’s, cardiovascular disease and in the last two years, COVID-19 infection. This book comprehensively reviews the etiology, pathophysiology, symptoms, diagnostic approach, imaging, risk stratification and contemporary treatment for pulmonary embolism in several patients’ scenarios. The chapters also cover treatment of deep vein thrombosis, the role or pulmonary embolism response teams (PERT), catheter interventions in pulmonary embolism as well as all challenges in chronic thromboembolic pulmonary hypertension (CTEPH). The book’s purpose is helping different physician profiles to properly treat often complex profiles of pulmonary embolism patients. The chapters are supported by figures and tables to help the readers understand mechanisms, guide diagnosis and treatment of pulmonary embolism in different clinical settings.

Keywords: Pulmonary embolism, diagnosis, prognosis, treatment, CTEPH

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Table of Contents

Preface

Chapter 1. Epidemiology, Pathophysiology, and Risk Factors for Pulmonary Embolism
Irena Mitevska
University Cardiology Clinic, Clinical Center, Medical Faculty, Saints Cyril and Metodij University, Skopje, North Macedonia

Chapter 2. The Diagnosis of Acute Pulmonary Embolism: The Integration of Clinical Scores, Biomarkers and Imaging Modalities
Irena Mitevska, PhD
University Cardiology Clinic, Clinical Center, Medical Faculty, Saints Cyril and Metodij University, Skopje, North Macedonia

Chapter 3. Risk Stratification and an Assessment of Pulmonary Embolism Severity
Irena Mitevska, PhD
University Cardiology Clinic, Clinical Center, Medical Faculty, Saints Cyril and Metodij University, Skopje, North Macedonia

Chapter 4. Non-Invasive Imaging in Acute Pulmonary Embolism
Elizabeta Srbinovska Kostovska, PhD
University Cardiology Clinic, Clinical Center, Medical Faculty, University “St Cyril and Metodij” Skopje, North Macedonia

Chapter 5. Medical Treatment of Acute Pulmonary Thromboembolism
Irena Mitevska, PhD
University Cardiology Clinic, Clinical Center, Medical Faculty, Saints Cyril and Metodij University Skopje, North Macedonia

Chapter 6. Catheter-Directed Treatment of Acute Pulmonary Embolism
Slobodan Obradovic, PhD
Clinic of Cardiology, Military Medical Academy, School of Medicine University of Defense, Belgrade, Serbia

Chapter 7. Thromboprophylaxis of Venous Thromboembolism
Sonja Salinger1, PhD and Irena Mitevska2, PhD
1Cardiology Clinic, Clinical Center Nis, Serbia
2University Cardiology Clinic, Medical Faculty, Skopje, North Macedonia

Chapter 8. Deep Venous Thrombosis: Diagnosis and Treatment
Marijan Bosevski, PhD
University Cardiology Clinic, St. Cyril and Methodius University, Faculty of Medicine, Skopje, North Macedonia

Chapter 9. Chronic Thromboembolic Pulmonary Hypertension (CTEHP): Diagnosis, Follow-Up, and Prognosis
Elizabeta Srbinovska Kostovska, PhD
University Clinic of Cardiology, Medical faculty, Skopje, North Macedonia

Chapter 10. Cancer-Associated Venous Thromboembolism
Sonja Salinger, PhD
Cardiology Clinic, Clinical Center Nis, Serbia

Chapter 11. Pulmonary Embolism and Pregnancy
Irena Mitevska1, PhD and Sonja Slinger2, PhD
1University Cardiology Clinic, Medical Faculty, Skopje, North Macedonia
2Cardiology Clinic, Clinical Center, Medical Faculty Nis, Serbia

Chapter 12. Regional Registry of Acute Pulmonary Embolism: Organization, Aims,
and Achievements
Slobodan Obradovic1,2, PhD, Boris Dzudovic2,3, PhD, Jovan Matijasevic4,5 PhD, Sonja Salinger6, PhD and Irena Mitevska7, PhD
1Clinic of Cardiology, Military Medical Academy, Belgrade, Serbia
2School of Medicine, University of Defense, Belgrade, Serbia
3School of Medicine, University of Defense, Belgrade, Serbia, Clinic of Emergency Internal Medicine, Military Medical Academy, Belgrade, Serbia
4School of Medicine, University of Defense, Belgrade, Serbia
5School of Medicine, University of Novi Sad, Serbia
6Clinic of Cardiology, Clinical Center Nis, University of Nis, Serbia
7University Cardiology Clinic, School of Medicine, University “St Cyril and Methodius” Skopje, North Macedonia

Chapter 13. Pulmonary Embolism Response Team (PERT): A Multidisciplinary Approach to Pulmonary Embolism Treatment
Slobodan Obradovic, PhD
Clinic of Cardiology, Military Medical Academy, School of Medicine University of Defense, Belgrade, Serbia

Index


Editor’s ORCID iD

Irena Mitevska: 0000-0002-2774-8559
Sonja Salinger: 0000-0001-9657-1665

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