PTEN: Structure, Mechanisms-of-Action, Role in Cell Signaling and Regulation

Ke Xu, PhD (Editor)
Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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PTEN (Phosphatase and Tensin Homolog) is a dual-specificity phosphatase and a member of the broad protein tyrosine phosphatase family. The PTEN gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It plays an important role in a variety of cellular processes including cell proliferation, cell differentiation, cell migration and cell death.

When the PTEN enzyme functions properly, it acts as part of a pathway that signals cells to stop dividing and can cause cells to undergo programmed cell death when necessary. These functions prevent uncontrolled cell growth. When the PTEN enzyme function is disrupted, it can lead to human diseases such as cancer, Cowden syndrome, chronic inflammatory syndromes, developmental defect and diabetes. Especially in cancer, PTEN is one of the most widely studied tumor suppressor genes. It has been found to be the second most frequently mutated gene in human cancers, second only to the tumor suppressor p53 gene.

The goal of this book is to provide a wide-ranging forum in the PTEN research field, in particular, with a focus on the structure, mechanism of action and role in cell signaling and regulation. The authors contributing to this book are all active researchers in the PTEN research field. They present the most recent advances, approaches and future prospects on PTEN research.

This book is suitable as both a professional reference and as a text for biological, medical, biomedical and pharmaceutical interest to scientists, clinicians, teachers and students. (Imprint: Nova Biomedical )

Preface

Chapter 1: PTEN and Cell Signaling in Health and Disease
(Swastika Sur and Devendra K. Agrawal, Department of Biomedical Sciences and Center for Clinical & Translational Research, Creighton University School of Medicine, Omaha, NE, USA)

Chapter 2: Post-translational Regulation of PTEN and its Implication in Cancer
(Syed Feroj Ahmed and Mrinal K. Ghosh, Signal Transduction in Cancer and Stem Cells Laboratory, Department of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), West Bengal, India)

Chapter 3: Novel Developmental Pathway Regulation Mechanisms of PTEN expression: Implications for Human Disease
(Travis J. Jerde, Departments of Pharmacology and Toxicology and Urology, IU Simon Cancer Center, Indianapolis, IN, USA)

Chapter 4: PTEN – A Molecule that Cancers Abuse to Overcome their Achilles Heels
(Kenichi Suda and Tetsuya Mitsudomi, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan, and others)
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Chapter 5: Targeting the PTEN Tumor Suppressor as an Anti-Cancer Therapeutic Strategy
(James J. Driscoll, Ahmed Khaled, Sajjeev Jagannathan and Arasakumar Subramani, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH, USA)

Chapter 6: The Impact of PTEN Tumor Suppressor on Outcome in Lung and Breast Cancer Patients
(Nikola Tanic, Tijana Stankovic and Nasta Tanic, University of Belgrade, Belgrade, Republic of Serbia)

Chapter 7: PTEN Involvement in Eye Embryology and Pathology
(Giulia Venturini and Alexandre P. Moulin, Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, and others)
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Chapter 8: Role of Post-translational Regulation of PTEN Activity in Cancer Cell Addiction to Heterozygous PTEN Mutations
(Alexey Goltsov, Yusuf Deeni, Hilal Khalil, Michael Idowu, Stylianos Kyriakidis, Gregory Goltsov, Simon P. Langdon, David J. Harrison and James Bown, Centre for Research in Informatics and Systems Pathology (CRISP), University of Abertay Dundee, Dundee, United Kingdom, and others)

Chapter 9: Role of PTEN in Vascular Organization and Anomalies
(Ionela Iacobas and Patricia E. Burrows, Drexel University College of Medicine, Pediatric Hematology-Oncology, Saint Peter's University Hospital, New Brunswick, NJ, USA, and others)

Chapter 10: PTEN on Angiogenesis and Ovarian Development: Experimental Data from a Primitive Vertebrate, Anguilla japonica
(Jin-Chywan Gwo, Ching-Fong Chang and Yung-Sen Huang, Department of Aquaculture, Taiwan National Ocean University, Keelung, Taiwan, and others)

Index

This book is suitable as both a professional reference and as a text for biological, medical, biomedical and pharmaceutical interest to scientists, clinicians, teachers and students.

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