PSA and Prostate Cancer


Jake A. Saylor (Editor)
Lionel B. Michaels (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

Prostate cancer (PCa) is a disease with high incidence and prevalence. It is the most common noncutaneous malignancy among men in the U.S. Discovery of prostate specific antigen (PSA) revolutionized screening of PCa which was largely dependent on detection of prostatic and phosphatase and digital rectal examination. This book reviews the use of PSA as a biomarker and the various aspects of the possible role of PSA in prostate cancer. Moreover, the N-glycan structures described in PSA are examined from different origins, such as prostate tumour cell lines, seminal plasma from healthy donors, serum from PCa and prostate BPH patients. This book also sheds light on the potential clinical utility of cell-free DNA for prostate cancer screening, diagnosis and prognosis and assesses the attributes of circulating DNA in its environment. Recent advances and clinical trials in immunotherapy for prostate cancer are highlighted, along with an emphasis on those that employ prostate specific antigen (PSA) as a target. Other chapters evaluate post prostatectomy PSA level and its association with prostate cancer relapse. PSA and signal transduction in Prostate Cancer and PSA in bone metastases and its connection to the immune system are examined as well. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Prostate Specific Antigen and Prostate Cancer
(Sudhir Isharwal, Zhou Wang, Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA)

PSA and Prostate Cancer
(Savita Yadav, Anil Kumar Tomar, Mayank Saraswat, Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India)

Circulating Cell-Free Blood Nucleic Acids as a Potential Molecular Marker
for Prostate Cancer
(Heidi Schwarzenbach, Klaus Pantel, Institute of Tumor Biology, University Medical, Center Hamburg-Eppendorf, Hamburg, Germany)

Targeting Prostate Specific Antigen for the Treatment of Prostate Cancer
(Anu Wallecha, Vafa Shahabi, Research and Development, Advaxis Inc, North Brunswick, New Jersey)

Significance of PSA Glycosylation in Prostate Cancer
(Rosa Peracaula, Pauline M. Rudd, Rafael de Llorens, Ariadna Sarrats, Unitat de Bioquímica i Biologia Molecular, Departament de Biologia, Universitat de Girona, Campus de Montilivi, Girona, Spain, and others)

Extending Ulam-Markov Indices from Mass-Spectra of Drugs and Proteins
to Proteome Serum Profiles of Prostate Cancer Patients
(Lázaro G. Pérez-Montoto, Giulio Ferino, María A. Dea-Ayuela, Francisco Bolas-Fernández, Gianni Podda, Humberto González-Díaz, Department of Microbiology & Parasitology and Department of Organic Chemistry, University of Santiago de Compostela (USC), Santiago de Compostela, Spain, and others)

Molecular Mechanism of PSA Expression in Prostate Cancer Cells
(Satoru Maruyama, Katsuya Nonomura, Shigetsugu Hatakeyama, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan)

Prostate-Specific Antigen in Specific Immunotherapy for Prostate Cancer
(Hanjun Qin, Shuren Zhang, Division of Immunology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, and others)

Feasibility and Usefulness of High-Dose-Rate Brachytherapy of Single Implant with Two Fractions Combined with External Beam Radiotherapy for Hormone-Naïve Localized Prostate Cancer
(Morio Sato, Yasutaka Noda, Shintaro Shirai, Kazushi Kishi, Toshiaki Shinka, Department of Radiology, Wakayama Medical University, Wakayama Shi, Wakayama, Japan, and others)

Screening for Prostate Cancer: Integrating the Current Evidence with Informed Decision Making
(Dragan Ilic, Monash Institute of Health Services Research, School of Public Health & Preventive Medicine, Monash University, Clayton, Australia)

Synthetic Peptides as Specific Activity Modulators of PSA
(Miikka Pakkala, Janne Weisell, Can Hekim, Ulf-Håkan Stenman, Hannu Koistinen, Ale Närvänen, Department of Biosciences, University of Kuopio, Kuopio, Finland, and others)

Prostate Cancer Research in Thailand: A Summary
(Viroj Wiwanitkit, Wiwanitkit House, Bangkha, Bangkok Thailand)

Prostate Specific Antigen: A Note on Clinical Laboratory Medicine Aspect
(Viroj Wiwantikit, Wiwanitkit House, Bangkhae, Bangkok Thailand)

PSA Nadir Post-Radical Prostatectomy Might Predict Long-Term Biochemical Recurrence
(Fernando Korkes, André Costa-Matos, ABC Medical School, São Paulo, Brazil)

PSA and its Inference: A Note from Interferomics Approach
(Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok Thailand)


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