Proton Pump Inhibitors (PPIs): Prevalence of Use, Effectiveness and Implications for Clinicians

Barbara Parker (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Proton pump inhibitors (PPIs) have become a mainstay of therapy not only in the practice of gastroenterology, but also for general medicine and even for the general public. Recently, proton pump inhibitors have been associated with a number of potential complications including impaired vitamin and mineral absorption, altered drug metabolism and increased risk for infections. The outline for the basis for these reported risks are examined in this book, the current clinical evidence is discussed, and the authors offer insight into the likely clinical significance of each complication.

Furthermore, the pathophysiology of acid secretion and inhibition, with a specific focus on the pharmacological principles surrounding the use of PPIs are reviewed. Relevant information on the management of acid-related disordered is provided for clinicians. Other chapters explore the current literature on potential complications associated with long-term PPI use, the benefits and risks of routine use of proton pump inhibitors in the intensive care unit (ICU), often associated with adverse events such as a significantly increased risk of infectious complications, and the use and misuse of proton pump inhibitors in the general population.
(Imprint: Nova Biomedical)

Preface

Chapter One
Proton Pump Inhibitors: Pharmacologic Principles of Use
(Abhijeet Waghray, Nisheet Waghray, Birju Shah, M. Michael Wolfe, Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA, and others)

Chapter Two
Benefits and Risks of Routine use of Proton Pump Inhibitors at the Intensive Care Unit
(Lukas Buendgens and Frank Tacke, Dept. of Medicine III, University Hospital Aachen, Germany)

Chapter Three
Use and Misuse of Proton Pump Inhibitors: A Survey on a General Population
(L. Lombardo, A. Giostra, L. Viganò, M. Tabone, A. Grassi, M. Gionco, G. Rovera, A. Bo, P. Malvasi, and Appropriateness Study Mauriziano Hospital Group, Gastroenterology Dpt, Mauriziano U.Ist Hospital (1980-2012), Turin, Italy, Since 2012: Gastroenterology Service, Poliambulatorio Statuto, Turin, Italy, Health Physics Dpt, Mauriziano U.Ist Hospital, Turin, Italy, and others)

Chapter Four
Reported Complications of Proton Pump Inhibitor Use: An Update for the Clinician
(Edward C. Oldfield IV and David A. Johnson, Eastern Virginia Medical School, Norfolk, VA, USA, and others)

Chapter Five
Adverse Events of Long-Term Proton Pump Inhibitor Therapy
(Nieka K. Harris, Amy N. Stratton, Fouad J. Moawad, Department of Medicine, Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA)

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