Proteomics: Advances in Research and Applications


Ricardo Parker (Editor)

Series: Systems Biology – Theory, Techniques and Applications
BISAC: SCI008000

This compilation provides a brief overview of proteomic techniques used in acute leukemia, including the high-throughput reverse phase protein array, which will highlight the importance of measuring proteins.

Following this, the authors discuss the molecular mechanism of oseltamivir and the advantages and disadvantages of using it. Proteomics- and transcriptomics-based alternatives to oseltamivir are described as well.

Additionally, the most recent research studies aiming to identify biomarkers for the early prediction of spontaneous preterm labor using mass spectrometry-based proteomics are reviewed.

In order to understand the mechanisms of efficient degradation of lignocellulosic biomass, a comprehensive analysis of carbohydrate-degrading and metabolic enzymes is required. As such, the authors summarize a proteome analysis of C. cellulovorans cultured with different carbon sources, and provide some insights as to how C. cellulovorans optimizes diverse enzymes depending on carbon sources.

The concluding chapter focuses on comparative fluorescence gel electrophoresis, which was invented in 2009 and has since then become the prime method for reproducible coordinate assignment in two-dimensional protein polyacrylamide gel electrophoresis.
(Imprint: Nova)

Table of Contents

Table of Contents


Chapter 1. Proteomics in Acute Myeloid Leukemia: Guidance to Targeted Therapy Selection and Risk Stratification
(Anneke D. van Dijk, Fieke W. Hoff and Steven M. Kornblau, Department of Pediatric Oncology/Hematology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, and others)

Chapter 2. Molecular Mechanism of Oseltamivir and Other Lead Compounds Towards Influenza a Virus Based on Proteomics and Transcriptomics Approaches
(Usman Sumo Friend Tambunan and Arli Aditya Parikesit, Bioinformatics Research Group, Department of Chemistry, Faculty of Mathematics and Sciences, University of Indonesia, Depok, Indonesia, and others)

Chapter 3. Mass Spectrometry-Based Proteomics for Preterm Labor
(Danai Mavreli, Nikolas Papantoniou, Dimitrios Gourgiotis and Aggeliki Kolialexi, 13rd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens Medical School, Athens, Greece, and others)

Chapter 4. Proteome Analysis of Soft-Biomass Microbial-Degradation Using Monolith-Based Nano-LC/MS/MS
(Shunsuke Aburaya, Wataru Aoki and Mitsuyoshi Ueda, Laboratory of Biomacromolecular Chemistry, Department of Applied Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture,
Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto, Japan)

Chapter 5. Standardization and quantification by Comparative Fluorescence Gel Electrophoresis (CoFGE)
(Alina Nippes, Doreen Ackermann and Simone König, Core Unit Proteomics, Interdisciplinary Center for Clinical Research, Westfalian Wilhelms-University of Münster, Münster, Germany)


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