Proteases: Functions, Mechanisms and Uses

Nelson Pérez Guerra (Editor)
Department of Analytical and Food Chemistry, Food Science and Technology Faculty, University of Vigo, Ourense, Spain

Series: Biochemistry Research Trends
BISAC: SCI007000




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Proteases or proteinases have a wide application in different industrial processes including cheese production, meat tenderization, production of protein hydrolysates, silver recovery and silk; in many other fields including biotechnological, baking, textiles, pharmaceutical and leather industries and also, as an additive to detergents and in bioremediation procedures. These enzymes are present in plants, animals and microorganisms (protozoa, bacteria, fungus and some types of algae and viruses).

Considering the wide applications of these enzymes, it is necessary to know their functions, origin (plants, animals, bacteria and fungus), classification and characteristics, action mechanisms, their specific target substrates and products obtained in the reactions that these enzymes catalyze, as well as their optimal temperature and pH of activity and stability.

The book provides an overview of the latest knowledge about the functions and action mechanisms of protease enzymes and their applications in different industrial fields. It addresses four important aspects: the main characteristics of proteases of different origins, the design of emerging technologies for production of novel proteases with enhanced specificity, stability and catalytic activity for a wide industrial application, utilization of proteases to produce functional foods and the use of protease inhibitors to control or block the activity of these enzymes for preventing diseases in humans and animals. It was felt necessary to include a chapter based on the use of bioinformatics resources (databases, tools, visualization and data analysis) to provide a better understanding of proteases and their functions at the molecular level.

Although production and application of bacterial and fungal proteases have long been reported, little is known about the proteases produced by insects (mainly those economic and medically important species), organisms inhabiting marine environments and protozoa, their action mechanisms, properties and physiology. This knowledge is important for designing new strategies for herbivory insect control to avoid the transmission or development of pathogens in their corresponding entity hosts (in case of insect digestive proteases), or designing specific antiparasitic drugs to block the action of proteases and avoid colonization and imminent parasitism (in case of protozoa proteases). In addition, the knowledge about the integrity and function of marine proteases under extreme reaction conditions could facilitate their application in a wider processing conditions than the terrestrial proteases.
(Imprint: Nova)


Chapter 1: Proteases: Useful Enzymes in Life
Karim Ennouri

Chapter 2: Insect Digestive Peptidases: Current State and Perspectives
Bianca Santos Henriques and Fernando Ariel Genta

Chapter 3: Marine Proteases
Arisaí C. Hernández-Sámano, Raquel García-Barrientos and Isabel Guerrero-Legarreta

Chapter 4: Protozoa Secrete Proteases to Degrade Components of the Host Innate Immune System
Magda Reyes-López, Mireya de la Garza, Moisés Martínez-Castillo, Mineko Shibayama, Jesús Serrano-Luna

Chapter 5: Novel Proteases Enzyme for Industrial Utilization
Tahereh Jamshidnejad Tosarmandazni, Mohammad Barshan-Teshnizi, Hasan Jalili

Chapter 6: Sweet Potato Protein Hydrolysates: Preparation by Enzymatic Hydrolysis, Functional Properties, Antioxidant and Antihypertensive Activities
Tai-Hua Mu, Miao Zhang

Chapter 7: Natural Protease Inhibitors and Sulphur-containing Amino Acids
Mammo Mengesha Erdaw

Chapter 8: Bioinformatics Resources for Protease Analysis
Anoushka Kotra, Neetu Jabalia


“Not just another book on enzymes, Proteases: functions, mechanisms and uses is a useful guide for scientists, integrating theory and practical examples in a thrilling way.” - Professor Dr. José Manuel Domínguez González, Industrial Biotechnology and Environmental Engineering Group “BiotecnIA,” Chemical Engineering Department, Science Faculty, Ourense Campus. Vigo University, Ourense, Spain

“Proteases: functions, mechanisms and uses focuses on proteases from different regional sources, with applications in a wide variety of industrial processes, namely cheese production, meat tenderization, production of protein hydrolysates, among others. The book appears as an appropriate tool to disseminate the latest knowledge about functions, mechanisms and applications of proteases in relevant industrial applications. It will provide useful information for both academics (PhD, postdocs and researchers, as well as undergraduate students) and industrials, thus covering a large audience.” - Andrea Gomez-Zavaglia PhD, Center for Research and Development in Food Cryotechnology (CIDCA, CCT CONICET, La Plata, Argentina

“Proteases are extremely important both from the metabolic/biological and industrial points of view, with a wide range of applications. This book is a comprehensive, practical and focused overview of the main and more recent features related with the available sources, functions and uses of proteases. It is an excellent resource to students, teachers, researchers and industry professionals that need to deal with this class of enzymes.” - Cristina Rocha, PhD, Researcher at Centre of Biological Engineering – University of Minho, Portugal

“Enzymes are strategic tools for the green industry and, among them, proteases are of main interest because of their wide applications. This book about proteases brings together basic knowledge about sources, classification and mechanisms of reaction of these enzymes, and particular and new concepts regarding proteases of marine, protozoa or vegetal origin, proteases implications in agriculture, and powerful tools related to directed evolution, metagenomics and bioinformatics applied to the screening, development and study of new proteases with enhanced properties. For all that, this book is a very useful and comprehensive source of knowledge and information for students, academics and biotechnologists who are interested in the study, research and application of these enzymes.” - Ana Torrado Agrasar, PhD, Professor/Researcher, Faculty of Sciences, University of Vigo, Ourense, Spain

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