Propofol: Pharmacokinetics, Medical Uses and Potential Health Effects


Albertina Florence (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

Propofol is an injectable agent that is commonly used for general anesthesia. In addition to its central nervous system depressant action, propofol may exhibit temporary analgesia although this has been debated. Several studies have reported analgesic effects of subhypnotic doses of propofol on pain perception in humans. Moreover, some recent clinical studies have reported that surgery patients receiving propofol anesthesia experienced reduced postoperative pain. This book discusses the pharmacokinetics, medical uses and potential health effects of propofol in further detail. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – Propofol and Nociception (pp. 1-14)
E. Carstens, Ph.D., Joseph F. Antognini, M.D., M.B.A. and Kenichi Takechi, M.D. (Department of Neurobiology, Physiology and Behavior University of California, Davis, CA, USA, and others)

Chapter 2 – Provocative Test with Propofolin Brain Arteriovenous Malformation Embolization Procedures (pp. 15-20)
Caleb E. Feliciano, M.D. and Rafael Rodríguez-Mercado, M.D., F.A.C.S. (University of Puerto Rico-Medical Sciences Campus, Department of Surgery-Section of Neurological Surgery Neuroendovascular Surgery and Stroke Program, San Juan, Puerto Rico)

Chapter 3 – An Evaluation of Propofol for Use in the Wada Test (pp. 21-42)
Gillian M. Fortune and James Andrew Magee (Department of Psychology Beaumont Hospital, Dublin, Ireland and others)

Chapter 4 – Sedation with Propofol (pp. 43-60)
Daniel Roberts, F.R.C.A., Jelena Devic, F.R.C.A. and Davinder Garewal, F.R.C.A. (St. George’s Hospital, Blackshaw Road, London, UK)

Chapter 5 – Propofol: A Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase with Potential Neuroprotective and Antitimor Properties (pp. 61-80)
Takefumi Inada, M.D. and Koh Shingu, M.D. (Department of Anesthesiology, Kansai Medical University, Osaka, Japan)

Chapter 6 – A New Method of Estimation of the Analgesic Properties of Propofol (pp. 81-90)
A. Yu. Elizarov and D.U. Gerasimov (Ioffe Physical Technical Institute RAS, St. Petersburg, Russia, and others)


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