Properties and Uses of Oleanolic Acid

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Nidhi Gupta, PhD – M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Meenakshi Dhanawat, PhD – Amity Institute of Pharmacy, Amity University Haryana, Amity Education Valley, Panchgaon, Manesar, Gurugram, Haryana, India

Series: Biochemistry Research Trends
BISAC: SCI007000; SCI013040; MED071000
DOI: https://doi.org/10.52305/VTYV8606

Cancer is a leading cause of death worldwide. In 2018, 9.6 million deaths were attributed to cancer, and it is affecting around 18 million patients each year. Natural products have been considered as the major source of lead compounds for cancer treatment. A large number of natural products have been reported by researchers all over the world and many of them are in clinical trials. In recent years, there has been a growing interest in pentacyclic triterpenoids such as Oleanolic acid, β-boswellic acid, ursolic acid, betulinic acid, glycyrrhetinic acid and maslinic acid as potential anticancer agents reflected by the exponential increase in the number of scientific publications and patents published on these natural products all over the world. Moreover, some of these pentacyclic triterpenoids have already been marketed in some countries as therapeutic agents for the treatment of several disorders such as cancer, diabetes, inflammation, liver disorders, etc. Two major derivatives of oleanolic acid, CDDO and CDDO-Me, have been entered into clinical trials against cancer. This book highlights the potential of oleanolic acid and its derivatives in the treatment of several human disorders. Initial chapters discuss the sources, extraction, biosynthesis and various reported biological activities of oleanolic acid while subsequent chapters describe the in vitro and in vivo applications of oleanolic acid and its different derivatives in several diseases such as bacterial infections, breast cancer, colon cancer and hepatic disorders. The last chapter of the book describes the nanoparticle-mediated delivery of oleanolic acid in cancer.

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Table of Contents

Preface

Chapter 1. Oleanolic Acid: Sources, Extraction, Characterization and Biosynthesis
Sarita Sharma¹, Nandini H.S.², Deepak Kumar Jha³, and Nandini Bhardwaj⁴
¹MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
²New Product Development Department, Natural Remedies Private Limited, Bangalore, India
³Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, India
⁴Department of Oral and Maxillofacial Pathology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India

Chapter 2.
Pharmacological Potential of Natural Biological Product: “Oleanolic Acid”
Ranjan Kumar Singh¹, Rajshree Dahiya², Naidu Narapusetty³, M. V. Jahansipriya⁴, Chennu M. M. Prasada Rao⁵, Tanniru Rajeswari⁶, Narla Mahendra Kumar⁷, and Komal Sharma⁸
¹,⁴-⁷Department of Pharmaceutical Sciences, Raffles University, Neemrana, Alwar, Rajasthan, India
²Jai Narain Vyas University, Jodhpur, Rajasthan, India
³Professor and Principal, Bellamkonda Institute of Technology and Sciences, Podili, Andhra Pradesh, India
⁸Department of Pharmaceutical Sciences, Bhupal Nobels’ University, Udaipur, Rajasthan, India

Chapter 3. Oleanolic Acid and Its Derivatives: Therapeutic Potential in Bacterial Infections
Rishabh Chalotra¹, Muhammed Amanat¹, Meenakshi Dhanawat², and Randhir Singh¹
¹Department of Pharmacology, Central University of Punjab, Bathinda, Punjab, India
²Amity Institute of Pharmacy, Amity University Haryana, Gurugram, India

Chapter 4. Oleanolic Acid and Its Derivatives: Therapeutic Potential in Breast Cancer
Sonia Kamboj, Minky Mukhija, Jyoti, and Anurag Bhargava
Ch. Devi Lal College of Pharmacy, Bhagwangarh, Jagadhri, Haryana, India

Chapter 5. Oleanolic Acid and Its Derivatives: Therapeutic Potential to Exhibit Hepatoprotective Effects
Jaya Rautela, Kiran Dhobhal, Poonam Joshi, Vikash Jakhmola, and Itika Guleria
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India

Chapter 6. Oleanolic Acid and Its Derivatives: Therapeutic Potential in Colon Cancer
Hitesh Kumar¹, S. M. Basavarajaiah², Bhawna Chopra³, Manu Sharma⁴, and Nidhi Gupta ⁵
¹RKSD College of Pharmacy, Kaithal, Haryana, India
²PG Department of Chemistry, Vijaya College, RV Road, Bengaluru, India
³Department of Pharmacy, Guru Gobind Singh College of Pharmacy, Yamunanagar, India
⁴Department of Pharmacy, National Forensic Science University, Delhi Campus, New Delhi, India
⁵M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India

Chapter 7. Nanoparticles-Mediated Delivery of Oleanolic Acid in Cancer
Kumbham Soniya¹,² and Biswas Swati¹
¹Nanomedicine Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad Campus, Jawahar Nagar, Medchal, Hyderabad, Telangana, India
²Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA

Index

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