Prognostic and Predictive Response Therapy Factors in Cancer Disease (Colorectal, Breast, Liver, Lung, Gastric, Renal and Prostate Cancers)

Vincenzo Canzonieri and Massimiliano Berreta (Editors)
Division of Oncology, CRO Aviano National Cancer Institute, IRCCS Via Franco Gallini, Aviano, Italy

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Exploring prognostic and predictive response therapy factors in cancer disease is one of the most exciting issues of modern oncological science. Targeting intracellular signalling molecules is one of the novel approaches in which basic and translational researches meet clinical practice to define the best management of malignancies. The goal for target therapies is to identify agents that target tumor-specific molecules, thus sparing normal tissues.

Those molecules are called biomarkers, and their identification is recommended for correct therapeutic planning. Hence, the contribution of clinical and surgical pathology to define cancer prognostic groups and treatment responsive tumors is essential not only for the efficacy of the cures, but also for ethical, economical, and social reasons. The promises of tailored (personalized) therapy are now almost certainly realistic and can give concrete hope to many cancer patients in the world. In this book, we have tried to describe the “state of art” in these fields of oncology, specifically considering prognostic and predictive response therapy factors in colorectal, breast, lung, gastric, renal, liver and prostate cancers.

(Imprint: Nova Biomedical)

Preface

Chapter 1 - Breast Cancer: Prognostic and Predictive Response Therapy Factors (pp. 1-28)
Tiziana Perin, Simon Spazzapan, Valentina Guida, Massimiliano Berretta, Gustavo Baldassarre and Vincenzo Canzonieri (Division of Pathology, and Medical Oncology C CRO, National Cancer Institute, IRCCS, Aviano, Italy)

Chapter 2 - Colorectal Cancer: Prognostic and Predictive Response Therapy Factors (pp. 29-56)
M. Berretta, G. Nasti, V. Canzonieri, M. Di Vita, U. Tirelli and C. De Divitiis (Department of Medical Oncology, CRO - National Cancer Institute, IRCCS Aviano; Department of Surgery, University of Catania, Catania; Division of Pathology, CRO - National Cancer Institute, IRCCS, Aviano; Medical Oncology SUN of Naples and IRCCS Fondazione Pascale Napoli, and Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy)

Chapter 3 - Gastric Cancer: Prognostic and Predictive Response Therapy Factors (pp. 57-84)
C. De Divitiis, V. Canzonieri, R. Cannizzaro, G. Nasti, P. De Paoli, R. Fisichella and M. Berretta (Medical Oncology, SUN of Naples and IRCCS Fondazione Pascale Napoli; Gastroenterology Division, CRO - National Cancer Institute, IRCCS, Aviano; Division of Pathology, CRO - National Cancer Institute, IRCCS, Aviano; Medical Oncology IRCCS Fondazione Pascale, Napoli; Scientific Directorate, CRO - National Cancer Institute, IRCCS, Aviano; Department of Surgery, University of Catania, Catania; Department of Medical Oncology, CRO - National Cancer Institute, IRCCS, Aviano, and Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy)

Chapter 4 - Primary Liver Cancer: Prognostic Factors and Predictive Response to Therapy (pp. 85-110)
A. Valdegamberi, A. Ruzzenente, S. Conci, F. Bagante, A. Cappellani and A. Guglielmi (Department of Surgery, Division of General Surgery A, University of Verona Medical School, Verona, Italy)

Chapter 5 - Lung Cancer (pp. 111-124)
Alessandra Bearz, Vittore Pagan and Tiziana Perin (Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano National Cancer Institute - IRCCS Via Franco Gallini, Aviano (PN), Italy; Department fo Surgical Oncology, Centro di Riferimento Oncologico di Aviano National National Cancer Institute - IRCCS Via Franco Gallini, Aviano (PN), and Division of Pathology Centro di Riferimento Oncologico di Aviano National National Cancer Institute - IRCCS Via Franco Gallini, Aviano (PN), Italy)

Chapter 6 - Prostate Cancer: Prognostic and Predictive Factors (pp. 124-146)
L. Fratino, M. C. Aquilano and V. Canzonieri (Department of Medical Oncology - CRO – Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, and Department of Pathology - CRO – Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Aviano, Italy)

Chapter 7 - Renal Cancer: Prognostic and Predictive Biomarkers (pp. 147-174)
Carla Cavaliere, Carmine D’Aniello, Sabrina Chiara Cecere, Marilena Di Napoli, Massimiliano Berretta, Renato De Domenico, Renato Franco, Michele Caraglia, Sandro Pignata and Gaetano Facchini (Uro-Gynaecologic Department, Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - IRCCS, Naples; Department of Oncology, Bolognini Hospital of Seriate, Seriate; Departments of Gynecological Oncology Medical Oncology and Scientific Direction, National Cancer Institute, Aviano (PN); Uro-Gynaecologic Department, Urology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - IRCCS, Naples; Pathology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione Giovanni Pascale' - IRCCS, Naples, and Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Caserta, Italy)

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