Principles of Free Radical Biomedicine. Volume II


Kostas Pantopoulos (Editor)
Lady Davis Institute for Medical Research, Montreal, QC

Hyman Schipper (Editor)
Lady Davis Institute for Medical Research, Montreal, QC

Series: Biochemistry Research Trends
BISAC: SCI007000

Recent years have witnessed an avalanche of new knowledge implicating free radicals in virtually every aspect of biology and medicine. It is now axiomatic that the regulated accumulation of reactive oxygen species (ROS) contributes to organismal health and well-being and that ROS serve as signaling molecules involved in cell growth, differentiation, gene regulation, replicative senescence and apoptosis. This book is an interdisciplinary text broken up into three consecutive volumes on the biochemistry and cellular/molecular biology of free radicals, transition metals, oxidants and antioxidants, and the role of oxidative stress in human health and disease. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Part 1. Free Radical Biology

Non-enzymatic antioxidants

1. Glutathione;pp. 3-19
(Dale Dickinson and Karen E. Iles, Dept. of Environmental Health Sciences, School of Public Health, Birmingham, AL, USA and others)

2. Vitamin C;pp. 21-40
(Tom Chan,Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA)

3. Vitamin E;pp. 41-60
(John R. Burnett and Michael Clarke,Royal Perth Hospital, Australia and others)

4. Nutritional antioxidants;pp. 61-77
(Tom S. Chan and Peter J. O’Brien, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA and others)

Antioxidant enzymes

5. Superoxide dismutases;pp. 81-99
(Diane E. Cabelli, Dept. of Chemistry, Brookhaven National Laboratory, Upton, NY, USA USA)

6. SOD mimics;pp. 101-128
(Ivan Spasojevic and Ines Batinic-Haberle,Dept of Medicine, Duke University Medical Center, Durham, NC,USA)

7. Catalases;pp. 129-145
(Christian Obinger, Paul G. Furtmuller and Marcel Zmocky,Dept. of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria and others)

8. Glutathione peroxidases;pp. 147-169
(Regina Brigelius-Flohé and Leopold Flohé, Dept.Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam-Rehbrucke, Nuthetal, Germany and others)

9. Thioredoxins and glutaredoxins;pp. 171-186
(Yves Meyer, Arne Holmgren, Universite de Perpignan, France and others)

10. Peroxiredoxins;pp. 187-201
(Sue Goo Rhee and Hyun Ae Woo, Ewha Womans University, Seoul,Korea)

11. Role and regulation of heme oxygenase in oxidative stress;pp. 203-227
(Phyllis Dennery,University of Pennsylvania School of Medicine, Philadelphia,USA)

Redox signaling

12. NF-kB transcription factor: Mechanism of redox regulation;pp. 231-250
Nathalie Grandvaux, Dept. of Biochemistry, Universite de Montreal, Qc, CanadaCanada)
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13. The Nrf2 (NFE2L2) transcription factor pathway;pp. 251-273
(Volker Blank, Dept. of Medicine and Physiology, McGill University, Quebec,Canada)

14. Redox-modulated AP-1 signaling;pp. 275-292
(Katerina K. Papachroni and Athanassios Papavassiliou, Medical School, University of Athens,Greece)

Subcellular Compartmentalization

15. Oxidative stress in mitochondria;pp. 295-314
(Valeria Valez, Adrian Aicardo, Adriana Cassina, Celia Quijano and Rafael Radi,Departmento de Bioquimica, Universidad de la Republica, Montevideo,Uruguay and others)

16. Oxidative stress and lysosomes;pp. 315-332
(Tino Kurz, Ulf T. Brunk and Alexei Terman,Division of Pharmacology, Linkoping University,Sweden and others)

17. Oxidative stress and peroxisomes;pp. 333-358
(Nina A. Bonekamp, Michael Schrader and H. Dariush Fahimi, University of Aveiro, Portugal and others)

18. Oxidative stress and the endoplasmic reticulum;pp. 359-378
(Elizabeth D. Crane, Ali A. Al-Hashimi and Rick Austin, Dept. of Medicine, McMaster University and St. Joseph’s Hospital, Hamilton, Ontario, Canada)

Metabolism and Physiology

19. Systemic and Cellular Iron Homeostasis;pp. 381-421
(Kostas Pantopoulos, Sir Mortimer B. Davis Jewish General Hospital and others Montreal,Canada)

20. Copper metabolism;pp. 423-443
(Stephanie Cull and Jim Koropatnick, University of Western Ontario,Canada and others)

21. Inflammation;pp. 445-462
(Nurlan Dauletbaev and Larry C. Lands,Research Institute of McGill University Health Centre, Canada and others)

22. Mitochondrial ROS and oxygen sensing;pp. 463-477
(Robert B. Hamanaka and Navdeep S. Chandel, Northwestern University Medical School, Chicago, IL,USA)

23. Oxygen radicals and glutathione in aging;pp. 479-500
(Wulf Dröge, Immunotec Inc., Vaudreuil-Dorion,Canada)

24. Oxidative stress, telomeres and cell senescence;pp. 501-511
(João F. Passsos and Thomas von Zglinicki, Henry Wellcome Laboratory for Biogerontology Research, Newcastle upon Tyne,UK and others)

25. Reactive Oxygen Species, Cell Death Signaling and Apoptosis;pp. 513-545
(Pragathi Pallepati and Diana A. Averill,Departement des sciences biologiques, Universite du Quebec a Montreal,Canada)

26. Glutathione and apoptosis;pp. 547-573
(Magdalena L. Circu and Tak Yee Aw,Dept. of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, USA)

27. Circadian redox regulation;pp. 575-627
(C. David Rollo,Dept. of Biology, McMaster University, Hamilton, Ontario, Canada)
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