Primary Central Nervous System Lymphoma (PCNSL): Incidence, Management and Outcomes

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Ryuya Yamanaka, PhD (Editor)
Laboratory of Molecular Target Therapy for Cancer, Dept. of Medical Science, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: MED056000

Primary central nervous system lymphoma (PCNSL) is an extranodal form of non-Hodgkin’s lymphoma (NHL) occurring in the craniospinal axis that accounts for 1–3% of all central nervous system malignancies. The majority of PCNSLs are high-grade B-cell lymphomas that differ from systemic B-cell NHLs in their less favorable prognosis. PCNSL appears to be increasing in incidence, reaching its peak in the fifth to seventh decades of life in immunocompetent patients. This book aims to provide up-to-date knowledge on the biology, diagnosis and treatment strategies associated with PCNSL. Separate chapters are specifically devoted to the biology, pathology, diagnosis, radiation therapy, chemotherapy regimens, emerging new agents, specific subtypes, and outcome associated with PCNSL. The authors are scientists and practicing physicians at university hospitals in Japan and South Korea. The book is written for postgraduate students, residents, basic scientists and physicians, as well as all medical professionals. The material covered in this book will serve as a foundation for the readers to keep up with current and future developments in this specific field of research and clinical practice. (Imprint: Nova Biomedical)

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Table of Contents

Preface

I. Epidemiology, Pathology and Biology

Chapter 1. Epidemiology of Primary Central Nervous System Lymphoma
Keishi Makino and Junichi Kuratsu (Department of Neurosurgery, Kumamoto University, Kumamoto, Japan)

Chapter 2. Pathology of Primary Central Nervous System Lymphomas
Yasuo Sugita (Department of Pathology, Kurume University School of Medicine, kurume, Japan)

Chapter 3. The Role of Tumor-Associated Microglia/Macrophages in Primary Central Nervous System Lymphoma: A New Target for Anti-Lymphoma Therapy?
Yoshihiro Komohara (Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan)

Chapter 4. Genetics of Primary Central Nervous System Lymphoma
Kenichi Yoshida (Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

II. Diagnosis

Chapter 5. Diagnostic Imaging of Primary Central Nervous System Malignant Lymphoma
Keisuke Miyake and Takashi Tamiya (Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kagawa, Japan)

Chapter 6. Cerebrospinal Fluid Interleukin-10 (Il-10) as a Diagnostic Marker in Primary Central Nervous System Lymphoma
Takashi Sasayama, Kazuhiro Tanaka, Katsu Mizukawa, Masamitsu Nishihara, and Eiji Kohmura (Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan, and others)

Chapter 7. Gene Expression Signature- based Prognostic Risk Score with Network Structure
Atsushi Kawaguchi (Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan)

Chapter 8. MicroRNAs Regulation and Primary Central Nervous System Lymphoma
Tomohiko Kanayama, Azusa Hayano and Ryuya Yamanaka (Laboratory of Molecular Target Therapy for Cancer, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, and others)

Chapter 9. A Cross Patient Image Analysis of PCNSL using Voxel-Based Lesion Mapping with Significant Focus on GCB and Non-GCB Classification
Manabu Kinoshita (Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan)

III. Management

Chapter 10. Radiotherapy for Primary CNS Lymphoma
Yuta Shibamoto (Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan)

Chapter 11. Clinical Outcome of High Dose Methotrexate-Based Vincristine and Procarbazine Combination Chemotherapy without Radiotherapy for Patients with Primary Central Nervous System Lymphoma
Ji Hwan Jang, Mee-Seon Kim and Young Zoon Kim (Division of Neuro-Oncology and Department of Neurosurgery, Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea)

Chapter 12. Farewell to Whole-Brain Radiotherapy in the Treatment of Primary Central Nervous System Lymphoma
Yasuo Iwadate (Departments of Neurological Surgery, Chiba University, Graduate School of Medicine, Inohana, Chuo-ku, Chiba, Japan)

Chapter 13. Temozolomide Chemotherapy for Primary Central Nervous System Lymphoma
Keishi Makino and Junichi Kuratsu (Department of Neurosurgery, Kumamoto University, Kumamoto, Japan)

Chapter 14. Salvage Therapy with High-Dose Cytarabine for Primary Central Nervous System Lymphoma
Hiroshi Kanno (Department of Neurosurgery, International University of Health and Welfare Atami Hospital, Japan)

Chapter 15. Salvage Therapy for Primary Central Nervous System Lymphoma
Ryuya Yamanaka (Laboratory of Molecular Target Therapy for Cancer, Graduate School for Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan)

Chapter 16. Molecular Targeted Therapy for DLBCL
Keisuke Kawamoto and Jun Takizawa (Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan)

IV. Specific Subtype

Chapter 17. Intraocular Lymphoma (Vitreoretinal Lymphoma)
Tokuhide Oyama (Division of Ophthalmology and Visual Sciences, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan)

Chapter 18. Intravascular Lymphoma
Shigeru Koyano, Hiroshi Doi and Fumiaki Tanaka (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan)

Chapter 19. Primary Central Nervous System Posttransplant Lymphoproliferative Disorders (PCNS-PTLD): Incidence, Management and Outcome
Masaya Honda, Michiaki Koga and Takashi Kanda (Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan)

V. Outcomes and Quality of Life

Chapter 20. Long-Term Quality of Life and Leucoencephalopathy in Primary CNS Lymphoma
Junya Fukai, Koji Fujita, Yuji Uematsu, and Naoyuki Nakao (Department of Neurological Surgery, Wakayama Medical University School of Medicine, Wakayama, Japan)

Chapter 21. Long-Term Outcome and Supportive Care in Patients with Primary Central Nervous System Lymphoma
Ryuya Yamanaka, Saori Yoshioka, Sawako Fujimoto, and Yoko Iwawaki (Laboratory of Molecular Target Therapy for Cancer, Graduate School for Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, and others)

Index


Additional Information

The book is written for postgraduate students, residents, basic scientists and physicians, as well as all medical professionals

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