Prenatal Alcohol Exposure and its Effects on Hippocampal Anatomy and Function


Joanna H. Sliwowska (Author) – Poznan University of Life Sciences, Poland

Series: Neuroscience Research Progress

This new book provides evidence in support of the hypothesis that prenatal alcohol/ethanol exposure (PAE) interferes with normal development and function of the hippocampus. The hippocampus is viewed as a target for early (prenatal) aversive events, such as PAE. Early life events are complex and interact with genetic factors in a manner which is not yet fully understood but which can profoundly change the structure and function of the hippocampus. This is not surprising as the hippocampus plays a crucial role not only in learning, memory storage and retrieval but also in controlling the stress response.

ISBN: N/A Categories: ,


Table of Contents


Organization and Content of the Book pp.1-2

I. Fetal Alcohol Spectrum Disorder (FASD): Historical
Perspective pp.3-5

II. Neurobiology, Anatomy and Development of Hippocampus pp.7-16

1. Neurobiology of the Hippocampus: Historical Perspective and Initial Connections between Alcohol Consumption and Hippocampal Damage

2. Hippocampal Neuroanatomy

3. Morphological Development of the Hippocampus

4. Hippocampus is a Very Plastic Brain Structure. You Can Teach Old Dog New Tricks

III. Hippocampus and Prenatal Alcohol Exposure pp.17-49

1. Animal Models of Ethanol Exposure: Methods of Ethanol Administrations

2. Magnetic Resonance Imaging (MRI) Studies of the Hippocampus in Humans with FASD

3. Hippocampal-Dependent Tasks in Children Prenatally Exposed to Alcohol and in Animal Models of Prenatal Ethanol Exposure

4. The Concept of Stress pp.51-58

5. The Hippocampus and the Stress or Hypothalamic-Pituitary-Adrenal (HPA) Axis

6. The Concept of Fetal Programming: Programming of the HPA Axis by Alcohol

7. The Stress Diathesis Hypothesis

8. Alterations in the Hippocampus and the HPA Axis in Humans with FASD and Rats Prenatally Exposed to Alcohol

9. Serotonergic Involvement in Programming of the HPA Axis: Alterations in the Serotonergic System in Animals Prenatally Exposed to Ethanol

10. Hippocampal Neurogenesis and Prenatal Alcohol Exposure

11. Mechanisms of Action of Alcohol on the Hippocampus

12. Prenatal Stress, Prenatal Alcohol Exposure and Dysregulation of the HPA Axis and the Hippocampus: Implications for the Neurobiology of Depression

IV. Can We Prevent or Reverse the Effect of Prenatal Alcohol Exposure on the Hippocampus? Intervention, Prevention and Implication

V. General Conlusion pp.59


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