Post-Acute and Long Term Geriatric Care Clinical Advisor. Volume I

Jochanan E. Naschitz
The Technion Israel Institute of Technology, Haifa, Israel and Geriatric Medical Center, Baitbalev, Nesher, Israel

Series: Geriatrics, Gerontology and Elderly Issues
BISAC: MED032000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Changing demographics have resulted in the elderly constituting a more significant proportion of the population. Many older people will develop functional impairment and disability, necessitating either support at home or admission to long-term care facilities, rehabilitation centers, psychiatric institutions and hospices. Guidance in the clinical challenges that face the staff of such institutions is essential.

Clinical practice guidelines dealing with many of the prevalent conditions in long-term care facilities have been published by the American Medical Directors Association; these aim to educate staff, improve patient outcomes, decrease avoidable transfers and reduce costs. Yet, guidelines do not cater methodically to problems resulting from the complex situations seen in older patients with multiple comorbidities. Textbooks are also often deficient in providing a focused approach to conditions and issues that are of importance in geriatric long-term care.

The present manuscript (Volumes I and II) focuses on case management in geriatric long-term care. Concise recommendations are provided, addressing diagnostic issues and management strategies. We have adopted an approach of dividing recommendations into ‘‘do’’ and ‘’do not’’ categories in order to guide physicians and nurses in their approach to conditions encountered frequently, to help them recognize ‘’red flag’’ signals, and to highlight significant unusual situations. When fine-tuning of management is indicated, the text goes into specifics, such as details on nutrition, pharmacology, medication dosing, therapeutic procedures, and the recognition of adverse events. Recent progress, shifting evidence, controversial issues and uncertainties are pinpointed. Expert advice is provided.

It is hoped that this book might prove to be a worthy contribution to the medical field, enriching doctors and nurses committed to long-term geriatric care.
(Imprint: Nova Biomedical)


Chapter 1. Introduction

Chapter 2. Essentials of Geriatric Care

Chapter 3. Geriatric Syndromes

Chapter 4. Urgenices and Emergencies

Chapter 5. Acute Disorders


“The subject of post acute care is very important and is the subject that makes geriatric care its special impact in medicine. This book contains the most important subjects in Post-Acute and Long Term Geriatric Care and serves as an excellent clinical advisor to the clinician. It covers the most common problems and subjects with many references and is written in a practical way to the reader by using the "Do" parts. The book also gives the approach to the subject through the long experience in acute care; as well as post acute care of clinician with excellent capacities in clinical education. Therefore, I think that this book can contribute to the daily work of many clinicians in an open field.” - Professor Yitshal N.Berner, Head, Geriatric Medicine, Meir Medical Center, Kfar Saba

“The subject of post acute care is very important and is the subject that makes geriatric care its special impact in medicine. This book contains the most important subjects in Post-Acute and Long Term Geriatric Care and serves as an excellent clinical advisor to the clinician. It covers the most common problems and subjects with many references and is written in a practical way to the reader by using the "Do" parts. The book also gives the approach to the subject through the long experience in acute care; as well as post acute care of clinician with excellent capacities in clinical education. Therefore, I think that this book can contribute to the daily work of many clinicians in an open field.” - Professor Yitshal N.Berner, Head, Geriatric Medicine, Meir Medical Center, Kfar Saba


Bartels SJ, Naslund JA. The underside of the silver tsunami - older adults and mental health care. N Engl J Med 2013;368:493-496.
Centers for Disease Control and Prevention and the Merck Company Foundation. The State of Aging and Health in America 2007. The Merck Company Foundation, Whitehouse Station, NJ 2007.
Cigolle CT, Langa KM, Kabeto MU, Tian Z, Blaum CS. Geriatric conditions and disability: the Health and Retirement Study. Ann Intern Med. 2007;147:156–164.
Cypreste R, Walsh K, Bedford M. Evidence-based medicine: what does the future hold? Postgrad Med J 2015;91:359-360.

Donald I, Hamilton S, for BGS Policy Committee. Assessment of older people for continuing care. BGS Best Practice Guide 2009; 4:6.
Fried LP, Tangen CM, Waiston J, Newman AB, Hirsch C, Gottdiener J, Seeman T. et al. Frailty in older adults. Evidence for a phenotype. J Gerontol Biol Sci Med Sci 2001;56:M146-56.
Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: clinical, research and policy implications of a core geriatric concept. JAGS 2007;55:780-791.
Kung J, Miller RR, Mackowiak PA. Failure of clinical practice guidelines to meet Institute of Medicine Standards: Two more decades of little, if any, progress. Arch Intern Med. 2012;172:1628-1633.
Larsson NG. Introduction: Biology of aging. Journal of Internal Medicine 2008;263:114-116.
Pacala JT, Sullivan GM. Geriatric Review Silabus: A Core Curriculum in Geriatric Medicine, 7th Edition. Library of Congress, 2010.
Pavel M, Jimison HB, Wactlar HD, Hayes TL, Barkis W, et al. The role of technology and engineering models in transforming healthcare. IEEE Rev Biomed Eng. 2013;6:156-177.
Reinis Lucey C. Medical education part of the problem and part of the solution. JAMA Intern Med. 2013;173:1639-1643.
Section for Enhancing Geriatric Understanding and Expertise Among Surgical and Medical Specialists (SEGUE), American Geriatrics Society. Retooling for an aging America: building the healthcare workforce. J Am Geriatr Soc. 2011;59:1537-1539.
Swartz K. Searching for a balance of responsibilities: OECD countries' changing elderly assistance policies. Annu Rev Publ Heath 2013;34:397-412.

Chapter 1

Caprio TV, Karuza J, Katz PR. Profile of physicians in the nursing home: time perception and barriers to optimal medical practice. J Am Med Dir Assoc. 2009;10:93-97.
Centers for Medicare and Medicaid Services. LTCF Data Compendium 2009 Edition. Available at:
datacompendium_508.pdf (Accessed on October 18, 2011).
Cheng HY. What long-term care providers need to know. Clin Geriatr Med 2011;27:193–198.
Donelan K, DesRoches CM, Dittus RS, Buerhaus P. Perspectives of physicians and nurse practitioners on primary care practice. N Engl J Med 2013; 368:1898-1906.
Hyer K, Thomas KS, Branch LG, Harman JS, Johnson CE et al. The influence of nurse staffing levels on quality of care in LTCF. Gerontologist. 2011;51:610–616.
Iler C, Goering M, Ralley K, Zaccagnini M. Taking on the challenge of clinical teaching in LTCF. J Gerontol Nur 2011;37:32-38.
Johnson MA. Changing the Culture of Nursing Homes. The Physician's Role. Arch Intern Med. 2010;170:407-409.
Konetzka RT, Park J, Ellis R, Abbo E. Malpractice litigation and LTCF quality of care. Health Serv Res. 2013;48(6 Pt 1):1920-1938.
Mody L, Bradley SF, Huang SS. Keeping the “Home” in LTCF:  Implications for infection prevention. JAMA Intern Med. 2013;173:853-854.
Mor V, Intrator O, Unruh MA, Cai S. Temporal and geographic variation in the validity and internal consistency of the LTCF Resident Assessment Minimum Data Set 2.0. BMC Health Serv Res. 2011;11:78.
Saffel-Shrier S, Gunning K, Van Hala S, Farrell T, Lehmann W, et al. Residency redesign to accommodate trends in geriatrics: an RC-FM variance to establish a patient-centered medical home in an assisted living facility. Am Med 2012;44:128-131.
Saliba D, Buchanan J. Making the investment count: revision of the Minimum Data Set for LTCF, MDS 3.0. J Am Med Dir Assoc 2012;13:602-610.
Shield R, Rosenthal M, Wetle T, Tyler D, Clark M, Intrator O. Medical staff involvement in nursing homes: development of a conceptual model and research agenda. J Appl Gerontol. 2014;33;75-96.
Sorrentino SA. Mosby’s Textbook for Nursing Assitants. Mosby Elsevier, St Louis, 2008, pp: 7-8.
Stevenson DG, Spittal MJ, Studdert DM. Does litigation increase or decrease health care quality?: a national study of negligence claims against LTCF. Med Care. 2013;51:430-436.
Studdert DM, Spittal MJ, Mello MM, O'Malley J, Stevenson DJ. Relationship between quality of care and negligence litigation in LTCF. N Engl J Med 2011; 364:1243-1250.
Ziemba R, Perry TE, Takahashi B, Algase D. “That model is sooooo last millennium!” Residential long term care as a system, not a place. J Hous Elderly. 2008;23:261–280.

Chapter 2

Boling PA, Chandekar RV, Hungate B, Purvis M, Selby-Penczak R, Abbey LJ. Improving outcomes and lowering costs by applying advanced models of in-home care. Cleveland Clin J Medicine 2013;80: e-Suppl 1 e-S7-e-S14.
Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, et al. Telemonitoring in patients with heart failure. N Engl J Med 2010; 363:2301–2309.
Edwards ST, Prentice JC, Simon SR, Pizer SD. Home-based primary fare and the risk of ambulatory care–sensitive condition hospitalization among older veterans with diabetes mellitus. JAMA Intern Med. 2014. doi:10.1001/jamainternmed.2014.4327.
Labson C, Sacco MM, Weissman DE, Gornet B, Innovative models of home-based palliative care. Cleveland Clin J Med 2013; 80: e-Suppl 1 e-S30-e-S35.

Chapter 3

Ahmed N, Tayor K, McDaniel Y, Dyer CB. The role of an acute care for the elderly unit in achieving hospital quality indicators while caring for frail hospitalized elders. Popul Health Manag 2012;15:236-240.
Ding YY, Anishenagaden J, Chong WF, Heng BH, Lim TK. Effectiveness of acute geriatric units in the real world: The case of short-term mortality among seniors hospitalized for pneumonia. Geriatr Gerontol 2012;7:211-217.
Ekdahl AW, Wirehn AB, Alwin J, Jaarsma T, Unosson M, et al. Costs and effects of an ambulatory geriatric unit (the AGe-FIT Study): a randomized controlled trial. J Am Med Dir Assoc. 2015 doi:10.1016/j.jamda.
Fox MT, Persaud M, Maimets I, O'Brien K, Brooks D et al. Effectiveness of acute geriatric unit care using acute care for elders components: a systematic review and meta-analysis. J Amer Geriatr Soc. 2012;60:2237-2245.

Hung WW, Ross JS, Farber J, Siu AL. Evaluation of the Mobile Acute Care of the Elderly (MACE) Service. JAMA Intern Med. 2013;173:990-996.
Shepperd S, Doll H, Angus RM, Clarke MJ, Iliffe S et al. Admission avoidance hospital at home. Cochrane Database Syst Rev. 2008;4:CD007491.
Silvester KM, Mohammed MA, Harriman P, Girolami A, Downes TW. Timely care for frail older people referred to hospital improves efficiency and reduces mortality without the need for extra resources. Age Ageing 2014;43:472-477.

Somme D, Lazarovici C, Drame M, Blanc P, Lang PO et al. The geriatric patient: Use of acute geriatrics units in the emergency care of elderly patients in France. Arch Gerontol Geriat 2011;52:40-45.

Chapter 4

Auriemma CL, Nguyen CA, Bronheim R, Kent S, Nadiger S et al. Stability of end-of-life preferences. A systematic review of the evidence. JAMA Intern Med. 2014;174:1085-1092.
Barrett JJ, Haley WE, Harrell LE, Powers RE. Knowledge about Alzheimer disease among primary care physicians, psychologists, nurses, and social workers. Alzheimer Dis Assoc Disord 1997;11:99-106.
Dwolatzky T, Clarfield AM, Bergman H. Non-specific presentations of illness in the elderly. In: Oxford Textbook of Primary Medical Care. Oxford University Press, UK. 2004.
Dwolatzky T, Clarfield AM. Doctor-patient relationships. In: Encyclopedia of Aging, 4th Edition. Springer Publishing Company, New York, USA. 2006.
Epstein RM, Korones DN, Quill TE. Withholding information from patients - when less is more. N Engl J Med 2010;362:380-381.
Gillick MR. Adapting advance medical planning for the LTCF. J Palliat Med 2004;7:357.
Gillick MR. Adapting advance medical planning for the LTCF. J Palliat Med 2004;7:357-361.
Grigoletto F, Zappala G, Anderson DW, Lebowitz, BD. Norms for the Mini-Mental State Examination in a healthy population. Neurology 1999; 53:315-320.
High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello VJ, et al. Clinical Practice Guideline for the Evaluation of Fever and Infection in Older Adult Residents of Long-Term Care Facilities: 2008 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases 2009;48:149–171.
Kane RL, Ouslander JG, Abrass IB, Resnick B. Essentials of Clinical Geriatrics. Sixth edition, McGraw Hill, New York, 2009.
Naeim A, Reuben DB, Ganz PA. Management of cancer in the older patient. Saunders, 2014:255-267.
Pacala JT, Yueh B. Hearing deficits in the older patient: “I didn't notice anything.” JAMA. 2012;307:1185-1194.
Pacala JT, Yueh B. Hearing deficits in the older Patient: “I didn't notice anything.” JAMA. 2012;307:1185-1194.
Smith AK, Lo B, Sudore R. When previously expressed wishes conflict with best interests. JAMA Intern Med. 2013;173:1241-1245.
Stoller JK. Electronic siloing: An unintended consequence of the electronic health record. Cleveland Clin J Med. 2013;80:406-409.
Wilson M. Should the pharmacy profession lead the medication reconciliation process? The ‘con’ side. Can J Hosp Pharm. 2011; 64: 373–374.

Chapter 5

Headly A. Communication skills: a call for teaching to the test. Am J Med 2007;120:912-915.
Kahn MW. Etiquette-based medicine. N Engl J Med. 2008;358:1988-1989.
Lamas D, Rosenbaum L. Freedom from the tyranny of choice - teaching the end-of-life conversation. N Engl J Med 2012; 366:1655-1657.
Pacala JT, Yueh B. Hearing deficits in the older patient: “I didn't notice anything.” JAMA. 2012;307:1185-1194.
Stickley T. From SOLER to SURETY for effective non-verbal communication. Nurse Educ Pract. 2011;11:395-398.
Tavel ME. The placebo effect: the good, the bad, and the ugly. Amer J Med 2014;127: 484-488.
Turnberg L. Improving communication between doctors and patients: a report of a working party. London: Royal College of Physicians; 1997.
Turner M, Payne S, O'Brien T. Mandatory communication skills training for cancer and palliative care staff: does one size fit all? Eur J Oncol Nurs. 2011;15:398-403. Gulbrandsen P, Jensen BF, Finset A. Self-efficacy among doctors in hospitals after a course in clinical communication. Tidsskr Nor Laegeforen. 2009;129:2343-2346.
Zisook S, Pies R, Corrub E. When is grief a disease? Lancet 2012; 379:1590.

Chapter 6

Bowker LK, Price JD, Smith SC. Oxford handbook of geriatric medicine. 2nd ed, 2012, Oxford Univ Press, pp:654-661.
Hickman SE, Sabatino CP, Moss AH, Nester JW. The POLST paradigm to improve end-of-life care: potential state legal barriers to implementation. J Law Med Ethics 2008;36:119.
Livingston G, Kelly L, Lewis-Holmes E, Baio G, Morris S, et al. A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia. Health Technol Assess. 2014;18:1-226.
Naik AD, Teal CR, Pavlik VN, Dyer CB, McCullough LB. Conceptual challenges and practical approaches to screening capacity for self-care and protection in vulnerable older adults. J Am Geriatr Soc 2008;56 Suppl 2:S266-270.
Schattner A. shared decision making: an alternative view. Mayo Clin Proc 2014;89:276.
Sessums LL, Zembrzuska H, Jackson JL. Does this patient have medical decision-making capacity? JAMA. 2011;306:420-427.

Chapter 7

Braunwald E, Morrow DA. Unstable angina. Is it time for a requiem? Circulation 2013;127:2452-2457.
Camaschella C. Iron-deficiency anemia. N Engl J Med 2015;372:1832-1843.
Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, et al. Red blood cell transfusion: a clinical practice guideline from the AABB. Ann Intern Med 2012;157:49-58.
Duffy MJ. Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem. 2001;47:624-630.
Eigbefoh JB, Isabu P, Ekpere E, Abebe J. The diagnostic accuracy of the rapid dipstick test to predict asymptomatic urinary tract infection of pregnancy. J Obstetr Gyneclo 2008;
28:490-495.Eur J Intern Med 2010;21:548-552.
Fincher RM, Page MI. Clinical significance of extreme elevation of the erythrocyte sedimentation rate. Arch Intern Med. 1986;146:1581.
Kim BJ, Lee KT, Moon TG, et al. How do we interpret an elevated carbohydrate antigen 19-9 level in asymptomatic subjects? Dig Liver Dis. 2009;41:364-369.
Konrad G. Are medication restrictions before FOBT necessary? Practical advice based on a systematic review of the literature. Can Fam Physician. 2012;58:939–948. http://www.
Lazo M, Selvin E, Clark JM. Clinical implications of short-term variability in liver function test results. Ann Intern Med 2008;148:348-352.
Marks V. False-positive immunoassay results: a multicenter survey of erroneous immunoassay results from assays of 74 analytes in 10 donors from 66 laboratories in seven countries. Clin Chem. 2002;48:2008-2016.
Mora S. Are advanced lipoprotein testing and subfractionation clinically useful? Circulation 2009;119:2396-2404.
Paralta C, Shlipak MG, Judd S, Cushman M, McClellan W, Zakai NA, et al. Detection of Chronic Kidney Disease With Creatinine, Cystatin C, and Urine Albumin-to-Creatinine Ratio and Association With Progression to End-Stage Renal Disease and Mortality. JAMA 2011;305:1545-1552.
Ruiz-González A, Falguera M, Porcel JM, Martínez-Alonso M, Cabezas P et al. C-reactive protein for discriminating treatment failure from slow responding pneumonia.
Segal R, Lubart E, Leibovitz A. Iaina A, Caspi D. Renal effects of low dose aspirin in elderly patients. IMAJ 2006;8:679-682.
Steensma DP, Tefferi A. Anemia in the elderly: how should we define it, when does it matter, and what can be done? Mayo Clin Proc 2007;82:958-966.
Sturgeon CM, Duffy MJ, Hofman BR, et al; National Academy of Clinical Biochemistry. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in liver, bladder, cervical, and gastric cancers. Clin Chem. 2010;56:e1-e48.
Vigushin DM, Pepys MB, Hawkins PN. Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease. J Clin Invest 1993;91:1351-1357.
WHO Guidelines on Drawing Blood: Best Practices in Phlebotomy. Geneva: World Health Organization; 2010.
Wolfe F, Pincus T. The level of inflammation in rheumatoid arthritis is determined early and remains stable over the longterm course of the illness. J Rheumatol 2001; 28:1817-1824.

Chapter 8

Batchvarov VN, Malik M, Camm AJ. Incorrect electrode cable connection during electrocardiographic recording. Europace 2007; 9:1081-1090.
Bonda RR, Finlava DD, Nugenta CD, Breenb C, Guldenringa D, Dayc MJ. The effects
of electrode misplacement on clinicians’ interpretation of the standard 12-lead electrocardiogram. Eur J Intern Med 2012;23:610-615.
Patel SI, Souter MJ. Equipment-related electrocardiographic artifacts: causes, characteristics, consequences, and correction. Anesthesiology 2008;108:138-148.

Chapter 9

Marshall EG, Clarke BS, Varatharasan N, Andrew MK. A long-term care-comprehensive geriatric assessment (LTC-CGA) tool: improving care for frail older adults? Can Geriatr J. 2015;18:2-10.
Stuck AE, Siu A, Wieland GD, Adams J, Rubenstein LZ. Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet 1993;342:1032-1036. Wetsbrook JI, Georgiou A, Black D, Hordern A. Comprehensive medical assessments for monitoring and improving the health of residents in aged care facilities: existing comprehensive medical assessments coverage and trial of a new service model. Australas J Ageing 2011;30:5-10.

Chapter 10

Aaron KJ, Sanders PW. Role of dietary salt and potassium intake in cardiovascular health and disease: a review of the evidence. Mayo Clin Proc. 2013;88:987-995.
American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults. Recommendations abstracted from the American Geriatrics Society Consensus Statement on Vitamin D for prevention of falls and their consequences. J Am Geriatr Soc. 2013 Dec 18. doi: 10.1111/jgs.12631.
Anker SD, von Haehling S. The Obesity Paradox in Heart Failure: Accepting Reality and Making Rational Decisions. Therapeutics 2011; 90:188–190.
Ashraf MJ, Cook JR, Rothberg MB. Clinical utility of folic acid testing for patients with anemia or dementia. J Gen Intern Med 2008;23:824-826.
Aspray TJ, Bowring C, Fraser W, Gittoes N, Macdonald H et al. National Osteoporosis Society vitamin D guideline summary. Age Ageing 2014;43:592-595.
Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ et al. Evidence-based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group. J Am Med Dir Assoc. 2013 doi: 10.1016/ j.jamda.2013.05.021. [Epub ahead of print].
Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyonns RA, Flicker L, Wark J, Jackson RD, Cauley JA, Meyer HE, Pfeifer M, Sanders KM, Stahlin HB, Theiler R, Dawson-Hughes B. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012;367:40-49.
Bjelakovic G, Gluud C. Vitamin and mineral supplement use in relation to all-cause mortality in the Iowa Women's Health Study: Comment on “Dietary Supplements and Mortality Rate in Older Women.” Arch Intern Med. 2011;171:1633-1634.
Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: metaanalysis. BMJ 2010; 341:c3691.
Bolland MJ, Leung W, Tai V, Gamble GD, Gray A, et al. Calcium intake and risk of fracture: systematic review. BMJ 2015;351:h4580.
Bouillanne O, Curis E, Hamon-Vilcot B, Nicolis I, Chrétien P, et al. Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: a randomized controlled trial. Clin Nutr. 2013;32:186-92.
Brown RE, Kuk JL. Consequences of obesity and weight loss: a devil’s advocate position. Obes Rev. 2015;16:77-87.
Chapman IM. Weight loss in older persons. Med Clin N Am 2011;95:579–593.
Costanzo S, Di Castelnuovo A, Donati MB, Iacoviello L, de Gaetano G. Cardiovascular and overall mortality risk in relation to alcohol consumption in patients with cardiovascular disease. Circulation 2010;121:1951-1959.
Cruz-Jentoft AJ; Baeyens JP; Bauer JM; Boirie Y; Cederholm T et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People.

Age Ageing 2010;39: 412-423.
Dalen JE. Devries S. Diets to Prevent Coronary Heart Disease 1957-2013: What Have We Learned? Amer J Med 2014;127:364–369.
Dhamarajan TS, Ugalino JT, Kanagala M, Pitchumoni S, Norkus AP. Vitamin B12 status in hospitalized elderly from LTCF and the community. J Am Med Dir Assoc 2000;1:21-24.
Ding M, Satija A, Bhupathiraju SN, Hu Y, Sun Q et al. Association of coffee consumption with total and cause specific mortality in 3 large prospective cohorts. Circulation. 2015;132:2305-2315.

DiNicolantonio JJ, Niazi AK, SAdaf R, O’Keefe JH, Lucan SC, Lavie CJ. Dietary sodium restriction: take it with a grain of salt. A, J Med 2013;126: 951-955.
Djousse L, Gaziano JM. Breakfast cereals and risk of heart failure in the physicians' health study I. Arch Intern Med 2007;167:2080-2085.
Donini LM, Poggiogalle E, Piredda M, Pinto A, Barbagallo M et al. Anorexia and eating patterns in the elderly. PLoS One 2013; 8: e63539.
Estruch R, Ros E, Salas-Salvadó J, Covas M-I, Corella D, Arós F et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279-90

Freedman ND, Park Y, Abnet CC, Hollenbeck AR, Sinha R. Association of coffee drinking with total and cause-specific mortality. N Engl J Med. 2012;366:1891-1904.
Ganguly R, Pierce GN. The toxicity of dietary trans fats. Food Chem Toxicol. 2015;78:170-176.
Halim SA, Newby LK. Review: Omega-3 fatty acid supplements provide no protective benefit in cardiovascular disease. Ann Intern Med 2012;157:Jc2-3.
Hayes KC, Pronczuk A. Replacing trans fat: the argument for palm oil with a cautionary note on interesterification. J Am Coll Nutr. 2010;29(3 Suppl):253S-284S.
He FJ, Li J, MacGregor GA. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials. BMJ 2013;346:f1325.
Heaney RP, Kopecky S, Maki KC, Hathcock J, Mackay D, Wallace TC. A review of calcium supplements and cardiovascular disease risk. Adv Nutr 2912;3:763-771.

Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-1930.
Holick MF. Vitamin D is not as taoxic as was once thought: a historical and an up-to-date perspective. Mayo Clin Proc. 2015; 90: 561-564.
Jung SB, Nagaraja V, Kapur A, Eslick GD. Association between vitamin B12 deficiency and long-term use of acid-lowering agents: a systematic review and meta-analysis. Intern Med J 2015;45:409-416.
Kotchen TA, Cowley AW Jr., Frohlich ED. Salt in health and disease - a delicate balance. N Engl J Med 2013; 368:1229-1237.
Kwak SM, Myung S-W, Lee YJ, Seo HG, for the Korean Meta-analysis Study Group. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease. A meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med. 2012;172:686-694.
Lee JH, O’Keefe JH, Lavie CJ, Marchioli R, Harris WS. Omega-3 fatty acids for cardioprotection. Mayo Clin Proc 2008;83:324-332.
Liu J, Sui X, Lavie CJ, et al. Association of coffee consumption with all-cause and cardiovascular disease mortality. Mayo Clin Proc. 2013;88:1066-1074.
Lopez-Garcia E, van Dam RM, Li TY, Rodriguez-Artalejo F, Hu FB. The relationship of coffee consumption with mortality. Ann Intern Med 2008;148:904-914.
Lucas M, Mirzaei F, Okerke OI, Willet WC, O’Reilly EJ, Koenen K, Ascherio A. Coffee, Caffeine, and Risk of Depression Among Women. Arch Intern Med. 2011;171:1571-1578.
Mathus-Vliegen EM. Obesity and the elderly. J Clin Gastroenterol. 2012;46:533-544.
McAuley PA, Artero EG, Sui X, Lee D, Church TS, Lavie CJ, Myers JN, España-Romero V, Blair SN. The obesity paradox, cardiorespiratory fitness, and coronary heart disease. Mayo Clin Proc 2012;87:443-451.
Mitrou PN, Kipnis V, Thiébaut ACM, Reedy J, Subar AF, Wirfält E et al. Mediterranean dietary pattern and prediction of all-cause mortality in a US population. Results from the NIH-AARP diet and health study. Arch Intern Med. 2007;167:2461-2468.
Moyer VA on behalf of the U.S. Preventive Services Task Force. Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2013;158: doi:10.7326/0003-4819-158-9-201305070-00603.
Mozaffarian D, Jacobson MF, Greenstein JS. Food reformulations to reduce trans fatty acids. N Engl J Med 2010;362:2037-2039.
Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR. Dietary supplements and mortality rate in oller women: The Iowa Women's Health Study. Arch Intern Med. 2011;171:1625-1633. N Engl J Med 2014;371:612-623.
Ney DM, Weiss JM, Kind AJ, Robbins J. Senescent swallowing: impact, strategies, and interventions. Nutr Clin Pract. 2009;24:395-413.
O’Donnell M, Mente A, Rangarajan S, McQueen MJ, Wang X, et al. O’Donnell MJ, Yusuf S, Mente A, Gao P, Mann JF et al. Urinary sodium and potassium excretion and risk of cardiovascular events. JAMA. 2011;306:2229–2238.
Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC. Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study. Am J Epidemiol. 2005;161:672-679.
Ravnskov U, DiNicolantonio JJ, Harcombe Z, Kummerow FA, Okuyama H, Worm N. The questionable benefits of exchanging saturated fat with polyunsaturated fat. Mayo Clin Proc. 2014;89:451-453.
Saunders J, Smith T, Stroud M. Malnutrition and undernutrition. Medicine 2011;39:45-50.
Smit E, Winters-Stone KM, Loprinzi PD, Tang AM, Crespo CJ. Lower nutritional status and higher food insufficiency in frail older US adults. Br J Nutr 2013;110:172-178.
Stange I, Bartram M, Liao Y, Poeschl K, Kolpatzik S, et al. Effects of a low-volume, nutrient- and energy-dense oral nutritional supplement on nutritional and functional status: A randomized, controlled trial in nursing home residents. J Am Med Dir Assoc. 2013 doi: 10.1016/j.jamda.2013.05.011. [Epub ahead of print].
Terre R, Mearin F. Oropharyngeal dysphagia after the acute phase of stroke: predictors of aspiration. Neurogastroenterol Motil. 2006;18:200-205.
Urinary sodium and potassium excretion, mortality, and cardiovascular events.
Wang X, Chen H, Ouyang Y, Liu J, Zhao G,

et al. Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies. BMC Medicine 2014;12:158 doi:10.1186/s12916-014-0158-6.
West SG, Gebauer SK, Kay CD, Bagshow DM, Savastano DM, Diefenbach C, Kris-Etherton PM. Diets containind pistachios reduce systoilic blood pressure and peripheral vascular responses to stress in adults with dyslipidemia. Hypertension 2012;60:58-63.
Willett WC, Dietary fats and coronary heart disease (Review). J Intern Med 2012; 272: 13–24.
Willett WC. Dietary fats and coronary heart disease (Review). J Intern Med 2012; 272: 13–24.

Chapter 11

American Geriatrics Society Ethics Committee and Clinical Practice and Models of Care Committee. American Geriatrics Society Feeding Tubes in Advanced Dementia Position Statement. J Am Geriatr Soc. 2014;62:1590-1593.

Blomberg J, Lagergren P, Martin L, et al. Novel approach to antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG): randomised controlled trial. BMJ 2010;341:c3115.
Blumenstein I, Shastri YM, Stein J. Gastroenteric tube feeding: techniques, problems and solutions. World J Gastroenterol. 2014;20:8505–8524.
Blumenstein I, Shastri YM, Stein J. Gastroenteric tube feeding: Techniques, problems and solutions. World J Gastroenterol. 2014;20:8505–8524.
Bruckstein AH. Managing the percutaneous endoscopic gastrostomy tube. Postgrad Med 1987;82:143.
Camilleri M, Parkman HP, Shafi MA, Abell TL, Geson L. Clinical guideline: management of gastroparesis. Am J Gastroenterol 2013;108:18-38.
DeLegge MH. Managing gastric residual volumes in the critically ill patient: an update. Curr Opin Clin Nutr Metab Care 2011;14:193-196.
Edes TE, Walk BE, Austin JL. Diarrhea in tube-fed patients: feeding formula not necessarily the cause. Amer J Med 1990;88:91-93.
Gorospe EC, Oxentenko AS. Preprocedural considerations in gastrointestinal endoscopy. Mayo Clin Proc. 2013;88:1010-1016.
Hsu CW, Sun SF, Lee DL, Lin SL, Wong KF et al. Impact of disease severity on gastric residual volume in critical patients. Worl J Gastroenterol 2011;17:2007-2012.
Jafri NS, Mahid SS, Minor KS, Idstein SR, Hornung CA et al. Meta-analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy. Alimentary Pharmacology & Therapeutics 2007;25:647-656.
Juern J, Verhaalen A. Gastrostomy-tube exchange. N Engl J Med 2014;370:e28.
Lee CG, Kang HW, Lim YJ, Lee JK, Koh MS, Lee JH, et al. pubmed?term=Yang%20CH%5BAuthor%5D&cauthor=true&cauthor_uid=24339709Comparison of complications between endoscopic and percutaneous replacement of percutaneous endoscopic gastrostomy tubes. J Korean Med Sci. 2013;28:1781-1787.
Liong MT. Safety of probiotics: translocation and infection. Nutr Rev 2008; 66:192–202.
Marinella MA. Refeeding syndrome: an important aspect of supportive oncology. J Support Oncol. 2009;7:11-16.
Mehanna H, Nankivell PC, Moledina J, Travis J. Refeeding syndrome-awareness, prevention and management. Head Neck Oncol 2009;1:4.
National Institute for Health and Clinical Excellence Nutrition support in adults. Clinical guideline CG32. 2006.
Richter JA, Patrie JT, Richter RP, Henry ZY, Pop GH et al. Bleeding after percutaneous endoscopic gastrostomy is linked to serotonin reuptake inhibitors, not aspirin or clopidogrel. Gastrointest endosc 20011;74:22-34e.
Roberts JR, Hedges JR. Clinical Procedures in Emergency Medicine, 5th ed, 2009, Saunders.
Singh D, Laya AS, Vaidya OU, Ahmed SA et al. Risk of bleeding after percutaneous endoscopic gastrostomy (PEG). Sif Dis Sci 2012;57:973-980.
Whelan K, Schneider SM. Mechanisms, prevention, and management of diarrhea in enteral nutrition. Current Opinion in Gastroenterology 2011;27:152–159.
Zhu Y, Shi L, Tang H, Tao G. Current considerations of direct percutaneous endoscopic jejunostomy. Can J Gastroenterol. 2012;26:92-96.

Chapter 12

Anderson JL, Horne BD, Stevans SM, Grove AS, Barton S et al. Randomized trial
of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation. Circulation 2007;116:2563-2570.
Aw A, Carrier M, Koczerginski J, McDiarmid S, Tay J. Incidence and predictive factors of symptomatic thrombosis related to peripherally inserted central catheters in chemotherapy patients. Thromb Res. 2012;130:323-326.
Bhidayasiri R, Fahn S, Weiner WJ, Gronseth GS, Sullivan KL, et al. Evidence-based guideline: treatment of tardive syndromes: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2013;81:463-469.
Brewer L, Williams D. Drug interactions that matter. Medicine 2012;40:371-375.
Dalleur O, Boland B, Spinewine A. Updated Beers criteria: greater applicability to Europe? J Am Geriatr Soc 2012;60:2188–2189.
Galvin R, Moriarty F, Cousins G, Cahir C, Motterlini N, et al. Prevalence of potentially inappropriate prescribing and prescribing omissions in older Irish adults: findings from The Irish LongituDinal Study on Ageing study (TILDA). Eur J Clin Pharmacol. 2014; 70:599-606.
Hill-Taylor B, Sketris I, Hayden J, Byrne S, O'Sullivan D, Christie R. Application
of the STOPP/START criteria: a systematic review of the prevalence of potentially inappropriate prescribing in older adults, and evidence of clinical, humanistic and economic impact. J Clin Pharm Ther. 2013;38:360-372.
Johnson DA, Chilton R, Liker HR. Proton-pump inhibitors in patients requiring antiplatelet therapy: new FDA labeling. Postgrad Med 2014;126:239-245.
Jonker MA, Osterby KR, Vermeulen LC, Kleppin SM, Kudsk KA. Does low-dose heparin maintain central venous access device patency?: a comparison of heparin versus saline during a period of heparin shortage. Parenter Enteral Nutr. 2010;34:444-449.
Li J, Tripathi RC, Tripathi BJ. Drug-induced ocular disorders. Drug Safety 2008;31:127-141.
Li J, Young R, Williams MV. Optimizing transitions of care to reduce rehospitalizations. Clevel Clin J Med 2014;81:312-320.
Mannheimer B, Eliasson EJ. Drug-drug interactions that reduce the formation of pharmacologically active metabolites: a poorly understood problem in clinical practice. Intern Med 2010;268:540–548.
Marasinghe KS. Computerised clinical decision support systems to improve medication safety in long-term care homes: a systematic review. BMJ open 2015;5:e006539.
Meeks TW, Culbewron JW, Horton MS. Medications in long-term care: when less is more. Clin Geriatr Med 2011;27:171-191.
O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, et. al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44:213-218.
Patterson Burdall D, Flores HC, Kruger J, Garretson S, Gorbien MJ et al. Use of proton pump inhibitors with lack of diagnostic indications in 22 Midwestern US skilled nursing facilities. J Am Med Dir Assoc 2013; doi: 10.1016/j.jamda.2013.01.021.
Rana AQ, Chaudry ZM, Blanchet PJ. New and emerging treatments for symptomatic tardive dyskinesia. Drug Des Devel Ther. 2013;7:1329–1340.
ResnickB, Fick DM. 2012 Beers criteria update: how should practicing nurses use the criteria? Geriatr Nurs 2012;33:253-255.
Schweizer AK, Hughes CM, Macauley DC,O’Neill C. Managing urinary tract infections in LTCF: a qualitative assessment. Pharm World Sci. 2005;27:159-165.
Tamura BK, Bell CL, Lubimir K, Iwasaki WN, Ziegler LA, Masaki KM. Physician intervention for medication reduction in a LTCF: The Polypharmacy Outcomes Project. J Amer Med Dir Assoc 2011;12:326-330.
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. BMJ 2015;351:h4984.
Wallace J, Paauw DS. Appropriate prescribing and important drug interactions in older adults. Med Clin N Am 2015;99:295-310.
Webster J, Osborne S, Rickard CM, New K. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2013;4:CD007798.
Wittich CM, Burkle CM, Lanier WL. Medication errors: an overview for clinicians. Mayo Clin Proc 2014; 89: 1116-1125.
Wolfstadt JI, Gurwitz JH, Field TS, Lee M, Kalkar S, et al. The effect of computerized physician order entry with clinical decision support on the rates of adverse drug events: a systematic review. J Gen Intern Med 2008;23:451-458.
World Health Organization. Topic 11: Improving medication safety. Secondary Topic 11: Improving medication safety. 2014.
who_mc_topic-11.ppt. National Health and Medical Research Council NHMRC information paper and statement: administrative report (Mar 2015) (
Zaal RJ, Jansen MM, Duisenberg-van Essenberg M, Tijssen CC, Roukema JA, van den Bemt PM. Identification of drug-related problems by a clinical pharmacist in addition to computerized alerts. Int J Clin Pharm. 2013;35:753-762.

Chapter 13

Allen SJ, Wareham K, Wang D, Bradley C, HutchingsH et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium diffi cile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2013; 382: 1249–1257.
Chun ED, Rodgers PE, Vitale CA, Collins CD, Malani PN. Antimicrobial use among patients receiving palliative care consultation. Am J Hosp Palliat Care. 2010;27:261-265.
Gandara E. Review: admission avoidance hospital at home decreases mortality at 6 months but does not differ from inpatient care for readmission. Evid Based Med. 2009; 14:79.
Gillick MR. Adapting advance medical planning for the LTCF. J Palliat Med 2004;7:357.
Giudicessi JR, Ackerman MJ. Azithromycin and risk of sudden cardiac death: Guilty as charged or falsely accused? Clevel Clin J Med 2013;80:539-544.
Ho JMW, Juurlink DN. Considerations when prescribing trimethoprim–sulfamethoxazole. CMAJ 2011;183:1851-1858.
Hooton TM. Clinical practice. Uncomplicated urinary tract infection. N Engl J Med 2012; 366:1028-1037.
Huttner A, Verhaegh EM, Harbarth S, Muller AE, Theuretzbacher U, et al. Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials. J Antimicrob Chemother. 2015;70:2456-2464.
Oplinger M, Andrews CO. Nitrofurantoin contraindication in patients with a creatinine clearance below 60 mL/min: looking for the evidence. Ann Pharmacother. 2013;47:106-111.
Rougier F, Ducher M, Maurin M, Corvaisier S, Claude D, et al: Aminoglycoside dosages and nephrotoxicity: quantitative relationships. Clin Pharm 2003;42: 493-500.
Rubinstein E, Keynan Y. Vancomycin revisited – 60 years later. Front Publ health 2014;2:217.
Schembri S, Williamson PA, Short PM, Akram A, Taylor J, Singanayagam A, et al. Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies. BMJ 2013; 346:f1235.
Seaton RA, Barr DA. Outpatient parenteral antibiotic therapy: Principles and practice. European Journal of Internal Medicine 2013;24:617-623.
Shepperd S, Doll H, Angus RM, Clarke MG, Iliffe S, Kalra L et al. Admission avoidance hospital at home. Cochrane Database Syst Rev. 2008;4:CD007491.
Sturm AW, Allen N, Rafferty KD, Fish DN, Toschlog E, et al. Pharmacokinetic analysis of piperacillin administered with tazobactam in critically ill, morbidly obese surgical patients. Pharmacotherapy 2014;34:28-35.
Zeuli JD, Wilson JW, Estes LL. Effect of combined fluoroquinolone and azole use on QT prolongation in hematology patients. Antimicrob Agents Chemother. 2013;57:1121-1127.

Chapter 14

Bauman AE, Reis RS, Sallis JF, Wells JC, Loos RJF, Martin BW. Correlates of physical activity: why are some people physically active and others not? Lancet 2012;380:258-271.
Burke RE, Juarez-Colunga E, Levy C, Prochazka AV, Coleman EA, et al. Rise of post–acute care facilities as a discharge destination of US hospitalizations [published online December 1, 2014]. JAMA Intern Med. doi:10.1001/jamainternmed.2014.6383.
DeJong G. Are we asking the right qestion about postacute settings of care? Archives of Physl Med Rehab 2014;95:218-221.
Desai AK. Revitalizing the aged brain. Med Clin N Am 2011;95:463–475.
Fink H, Hemmy L, Macdonald R, Carlyle MH, Olson CM et al. Intermediate and long term cognitive outcomes after cardiovascular procedures in older adults: a systematic review. Ann Intern Med 2015;163:107-117.
Gill TM, Murphy TE, Gahbauer EA, Allore HG. The course of disability before and after a serious fall. JAMA Intern Med. 2013;173:1780-1786.
Griffiths J, Hatch RA, Bishop J, Morgan K, Jenkinson C, et al. An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study.

Crit Care 2013;17:R100.
Haines TP, Hill A-M, Hill KD, McPhail S, Oliver D, Brauer S, Hoffmann T, Beer C. Patient education to prevent falls among older hospital inpatients. A randomized controlled trial. Arch Intern Med 2011;171: 516-524.
Hubbard RE, Theou O. Frailty: enhancing the known knowns. Age Ageing 2012;41:574-575.
Jenq GY, Tinetti ME. Post–Acute CareWho Belongs Where? JAMA Intern Med. 2015;175:296-297.
Landefeld CS, Palmer RM, Kresevic DM, Fortinsky RH, Kowal J. A randomized trial of care in a hospital medical unit especially designed to improve the functional outcomes of acutely ill older patients. N Engl J Med. 1995;332:1338-1344.
Mazière S, Lanièce I, Hadri N, Bioteau C, Millet C, Couturier P, Gavazzi G. Predictors of functional decline of older persons after an hospitalisation in an acute care for elder unit: Importance of recent functional evolution. Presse Med. 2011;40:e101-e110.
Panharipande PP. Girard TD, Jockson JC, Morandi A, Homkpson JL et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013;369:1306-1316.
Prestmo A, Hagen G, Sletvold O, Helbostad JL, Thingstad P, et al. Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Lancer 2015; 385:1623-1633.
Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, IInouye SK, Jones RN. Cognitive trajectories after postoperative delirium. N Engl J Med 2012;367:30-39.
Taylor D. Physical activity is medicine for older adults. Postgrad Med J 2014;90:26–32.
Vona M, Codeluppi GM, Iannino T, Ferrari E, Bogouslavsky J, von Seegesser LK. Effects of different types of exercise training followed by detraining on ednothelium-dependent dilatation in patients with recent myocardial infarction. Circulation 2009;119:1601-1608.
Wen CP, Wai PM, Tsai MK, Yang YC, David TY, Lee CM, Chan HT, Tsao CK. Tsai SP, Wu X. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 2011; 378: 1244–1253.

Chapter 15

Boyce JM, Pittet D. Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HIPAC/
SHEA/APIC/IDSA Hand Hygiene Task Force. Am J Infect Control. 2002;30:S1-46.
Centers for Disease Control and Prevention. Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP): United States, 2012-13 influenza season. MMWRMorb Mortal Wkly Rep. 2012;
Duval X, Delahaye F, Alla F, Tattevin P, Obadia JF, Le Moing V et al. Temporal trends in infective endocarditis in the context of prophylaxis guideline modifications: three successive population-based surveys. J Am Coll Cardiol 2012;59:1968-1976.
Enzler MJ, Berbari E, Osmon DR. Antimicrobial prophylaxis in adults. Mayo Clin Proc. 2011;86:686-701.
Fätkenheuer G, Hirschel B, Harbarth S. Screening and isolation to control meticillin-resistant Staphylococcus aureus: sense, nonsense, and evidence. Lancet 2015;385:1146–1149. Elizaga ML, Weinstein RA, Hayden MK. Patients in long-term care facilities: a reservoir for vancomycin-resistant enterococci. Clin Infect Dis. 2002;34:441-446.
Flannery B, Clippard J, Zimmerman RK, Nowalk MP, Jackson ML, et al. Early estimates of seasonal influenza vaccine effectiveness - United States, january 2015. Morb Mortal Wkly Rep. 2015;64:10-15.
Gould D. Isolation precautions to prevent the spread of contagious diseases. Nurs Stand 2009;23:47-55.
Greenhawt MJ, Spergel JM, Rank MA, Green TD, Mansoor D, et al. Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy. Ann Allergy Asthma Immunol 2012; 109:426-430.
Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009). The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Eur Heart J. 2009; 30:2369-2413.
Keating GM. Shingles (herpes zoxter) vaccine (zostavax ®) (®)): a review of its use in the prevention of herpes zoster and postherpetic neuralgia in adults aged ≥50 years. Drugs 2013;73:1227-1244.
Lee N, Chan PK, Hui DS, Rainer TH, Wong E, Choi KW et al. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. J Infect Dis 2009;200:492-500.
Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med 2015;372:1539-1548.
Schuchat A. Pneumococcal prevention gets older and wiser. JAMA Intern Med. 2015; 175:1897-1898.
Smith PW, Bennett G, Bradley S, et al. SHEA/APIC Guideline: Infection prevention and control in the long-term care facility. Amer J Infect Control 2008;36:504-535.
Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 2014;63:822–825.
Wong K, Campitelli MA, Stukel TA, Kwong JC. Estimating influenza vaccine effectiveness in community-dwelling elderly patients using the instrumental variable analysis method [published online February 27, 2012]. Arch Intern Med. 2012;172(6):ioi110023484-491.

Chapter 16

Dialla PO, Quipourt V, Gentil J, Marilier S, Poillot ML, et al. In breast cancer, are treatments and survival the same whatever a patient's age? A population-based study over the period 1998-2009. Geriatr Gerontol Int. 2014, doi: 10.1111/ggi.12327.
Hissett J, Folks B, Coombs L, LeBlanc W, Pace WD. Effects of changing guidelines on prescribing aspirin for primary prevention of cardiovascular events. J Am Board Fam Med. 2014;27:78-86.
Kent KC. Abdominal aortic aneurysms. N Engl J Med 2014;371:2101-2108.
Ko CW, Sonneberg A. Comparing risks and benefits of colorectal cancer screening in elderly patients. Gastroenterology 2005;129:1163-1170.
Maeda K, Yasuda N, Ohara H, Mino Y. Effects on mortality of getting the basic health examination under the Health Services for the Elderly Act and modification of the effects by health status among elderly persons in a rural community. J Epidemiol. 2000;10:22-28.
Malmgren JA, Parikh J, Atwood MK, Kaplan HG. Improved prognosis of women aged 75 and older with mammography-detected breast cancer. Radiology. 2014 [Epub ahead of print].
Moyer VA on behalf of the U.S. Preventive Services Task Force. Screening for Glaucoma: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med 2013; doi:10.7326/0003-4819-159-6-201309170-00685.
Park K, Bavri AA. Aspirin: Its risks, benefits, and optimal use in preventing cardiovascular events. Cleveland Clin J Med 2013;80:318-326.
Ridker PM, Cook NR, Lee IM, Gordon D, Caziano JM, Manzon JE et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005;352:1293-1304.
Torke AM, Schwartz PH, Holtz LR, Montz K, Sachs GA. Older adults and forgoing cancer screening: “I think it could be strange.” JAMA Intern Med. 2013;173:526-531.
Tran AH, Ngor EWN, Wu BU. Surveillance colonoscopy in elderly patients. A retrospective cohort study. JAMA Intern Med. 2014;174:1675-1682.
U.S. Preventive Services Task Force Recommendation Statement: Screening for Lung Cancer
US Preventive Task Force 1996, Guide to Clinical Preventive Services, 2d Edition, 2000, Updated online 2007 (

Chapter 17

An HJ, Kim IK, Lee JE, Kang YJ, Kim CH, et al. Nebulized morphine for intractable cough in advanced cancer: two case reports. J Palliat Med. 2015;18:278-281.
Attal N, Cruccu G, Baron R, Haanpaa, Hansson P et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 2010;17: 1113-e88.
Bausewein C, Simon ST. Inhaled nebulized and intranasal opioids for the relief of breathlessness. was effective in controlling intractable cough due to cancer and it was convenient and safe. Cur Opin Support Palliat Care. 2014;8:208-212.
Bennett MI. Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review. Palliat Med. 2011;25:553-559.
Berger TG, Shive M, Harper GM. Pruritus in the older patient: a clinical review. JAMA. 2013;310:2443-2450.
Blinderman CD, Billings JA. Comfort care for patients dying in the hospital. N Engl J Med 2015; 373:2549-2561.
Bozorgnia B, Mather PJ. Current management of heart failure. When to refer to heart failure specialist and when hospice is the best option. Med Clin N Am 2015;99:863-876.
Bruera E, Valero V, Driver L, Shen L, Willey J, et al. Patient-controlled methylphenidate for cancer fatigue: a double-blind, randomized, placebo-controlled trial. J Clin Oncol 2006;24:2073-2078.
Chaham MS, Dodds Ashley ES, Svengsouk JS, Juba KM. Dose ratios between high dose oral morphine or equivalents and oral methadone. J Palliat Med. 2013;16:947-950.
Cherny NI, Radbruch L, on behalf of the Board of the European Association for Palliative Care European Association for Palliative Care (eapc) recommended framework for the use of sedation in palliative care. Palliat Med. 2009;23:581-593.
Chibnall JT, Tait RC, Harman B, Luebbert RA. Effect of acetaminophen on behavior, well-being, and psychotropic medication use in nursing home residents with moderate-to-severe dementia. J Am Geriatr Soc 2005;53:1921-1192.
Christakis NA, Lamont EB. Extent and determinanats of error in doctors’ prognoses in terminally ill cancer patients: prospective cohort study. BMJ 2000;320:469.
Clarke G, Harrison K, Holland A, Kuhn I, Barklay S. How are treatment decisions made about artificial nutrition for individuals at risk of lacking capacity? A systematic literature review. PloSOne 2013;8:e61475.
Cohen LM. Murder and Euthanasia. Accusations against physicians. Mayo Clin Proc 2012;87:814–816.
Collins LG, Parks SM, Winter L. The state of advance care planning: one decade after SUPPORT. Am J Hosp Palliat Care 2006;23:378-384.
Collis E, Mather H. Nausea and vomiting in palliative care. BMJ 2015;351:h6249.
Dalal S, Bruera E. Dehydration in cancer patients: to treat or not to treat. J Support Oncol 2004; 2:467-479.
Delgado-Guay MO, De La Cruz MG, Epner DE. ‘I don't want to burden my family’: handling communication challenges in geriatric oncology. Ann Oncol 2013;24 (suppl 7): vii30-vii35.
Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007;132:237-251.
Emanuel LL, Librach LS. Palliative Care Core Skills and Clinical Competencies. 2nd Ed, Saunders, 2011:115-128.
Farrell M, Buchbinder R, Hall W. Should doctors prescribe cannabinoids? BMJ 2014;348:g2737.
Fournier J-P, Yin H, Nessim SJ, Montastruc J-L, Azoulay L. Tramadol for noncancer pain and the risk of hyponatremia. Am J Med 2015;128:418-425.e5.
Gilron I, Baron R, Jensen T. Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc 2015;90:532-546.
Good P, Afsharimani B, Movva R, Haywood A, Khan S, et al. Therapeutic challenges in cancer pain management: a systematic review of methadone. J Pain Palliat Care Pharmacother. 2014;28:197-205.
Good P, Cavenagh J, Mather M, Ravenscroft P. Medically assisted hydration for palliative care patients. Cochrane Database Syst Rev 2008:CD006273.
Grotenhermen F, Muller-Vahl K. The therapeutic potential of cannabis and cannabinoids. Dtsch Arztebl Int 2102;109:495-501.
Hui D, dos Santos R, Chisholm G, Bansal S, Silva TB et al. Clinical signs of impending death in cancer patients. Oncologist 2014;19:681-687.
Jaarsma T, Beattie JM, Ryder M, Rutten FH, McDonagh T, Mohacsi P et al. on behalf of the Advanced Heart Failure Study Group of the HFA of the ESC Palliative care in heart failure: A position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2009;11:433-443.
Karlsson J, Söderström A, Augustini BG, Berggren AC. Is buprenorphine transdermal patch equally safe and effective in younger and elderly patients with osteoarthritis-related pain? Results of an age-group controlled study. Curr Med Res Opin. 2014;30:575-587.
Keeley PW, Noble S. Palliative care: introduction. Medicine 2011;39:635.
Kelley AM, Morrison RS. Palliative care for the seriously ill. N Engl J Med 2015;373:747-755.
Klokel M, Cherny N. Treatment of dyspnoea in advanced cancer patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2015;26 Suppl 5:v169-v173.
Kutner JS, Blatchford PJ, Taylor Jr DH, Ritchie CS, Bull JH, et al. Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness. A randomized clinical trial. JAMA Intern Med. 2015;175:691-700.
Lamas D, Rosenbaum L. Freedom from the tyranny of choice-teaching the end-of-life conversation. N Engl J Med 2012;366:1655-1657.
LeBlanc TW. Communication skills training in the twenty-first century. MA Journal of Ethics. 2015;17:138-141.
Leeuw M, Goossens MEJB, Linton SJ, Crombez G, Boersma K, et al. The fear-avoidance model of musculoskeletal pain: current state of scientific evidence. J Behav Med 2007;30:77–94.
Lewis EF. End of life care in advanced heart failure. Curr Treat Options Cardiovasc Med 2011;13:79-89.
Malec M, Shega JW. Pain management in the elderly. Med Clin N Am 2015;99:337–350.
McKinnon M, Azevedo C, Bush SH, Lawlor P, Pereira J. Practice and documentation of palliative sedation: a quality improvement initiative. Cur Oncol. 2014;21:100-103.
Mitchell SL, Black BS, Ersek M, Hanson LC, Miller SC, Sachs GA et al. Advanced Dementia: State of the Art and Priorities for the Next Decade. Ann Intern Med. 2012;156:45-51.
Morris D, Galicia-Castillo M. Dying with dyspnea in the hospital. Am J Hosp Palliat Care. 2015. pii: 1049909115604140.
Moss AH. Revised dialysis clinical practice guideline promotes more informed decision-making. Clin J Am Soc Nephrol 2010;5:2380-2383.
Moulin D, Boulanger A, Clark AJ, Clarke H, Dao T, et al. Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society. Pain Res Manag. 2014;19:328-335.
Murphy LM, Lipman TO. Percutaneous endoscopic gastrostomy does not prolong survival in patients with dementia. Arch Intern Med 2003;163:1351-1353.
Murray SA, Boyd K, Sheikh A. Palliative care in chronic illnesses: We need to move from prognostic paralysis to active total care. BMJ 2005;330:611-612.
Naeim A, Reuben DB, Ganz PA. Management of cancer in the older patient. Saunders, 2014:255-267.
Nelson LS, Juurlink DN. Tramadol and hypoglycemia. One more thing to worry about. JAMA Intern Med. 2015;175:194-195.
Nguyen NQ. Pharmacologic therapy of feed intolerance in the critical ill. World J Gastrointest Pharmacol Ther 2014;5:148-155.
Paley CA, Tashani OA, Bagnall AM, Johnson MI. A Cochrane systematic review of acupuncture for cancer pain in adults. BMJ Support Palliat Care. 2011;1:51-55.
Quill TE, Abemethy AP. Generalist plus specialist palliative care - Creating a more sustainable model. N Engl J Med 2013;368:1173-1175.
Schwartz DB, Posthauer ME, O'Sullivan Maillet J. Practice paper of the academy of nutrition and dietetics abstract: ethical and legal issues of feeding and hydration. J Acad Nutr Diet. 2013;113:981.
Seow H, Brazil K, Sussman J, Pereira J, Marshall D, et al. Impact of community based, specialist palliative care teams on hospitalisations and emergency department visits late in life and hospital deaths: a pooled analysis. BMJ 2014;348:g3496.
Sharpe M, Walker J, Hansen CH, Martin P, Symeonides S, et al. Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT Oncology-2): a multicentre randomised controlled effectiveness trial. Lancet 2014;384:1099-1108.
Smallwood N, Le B, Currow D, Irwing L, Philip J. Management of refractory breathlessness with morphine in patients with chronic obstructive pulmonary disease. Am J Med Sci 2015;350: DOI: 10.1111/imj.12857.
Smith TJ, Saiki CB. Cancer pain management. Mayo Clin Proc. 2015;90:1428-1439. Wiffen PJ, Wee B, Moore RA. Oral morphine for cancer pain. Cochrane Database Syst Rev. 2013;7:CD003868.
Smith TJ. Symptom management in the older adult: 2015 update. Clin Geriatr Med 2015;31:155-175.
Thapa SD, Schairer JM. Narcotic-induced pain. Am J Med 2015;128:e7-e8.
Vadivelu N, Kai A, Maslin B, Kodumudi G, Legler A et al. Tapentadol extended release in the management of peripheral diabetic neuropathic pain. Ther Clin Risk Manag. 2015;11:95-105.
van den Elsen GA, Ahmed AI, Lammers M, Kramers C, Verkes RJ, et al. Efficacy and safety of medical cannabinoids in older subjects: a systematic review. Ageing Res Rev. 2014;14:56-64.
Volicer L, van der Steen JT. Outcome measures for dementia in the advanced stage and at the end of life. Advances in Geriatrics. 2014, Article ID 346485.
Wheatley VJ, Finlay IG. Ethical issues in palliative care. Medicine 2011;39:680-682.
White-Chu EF, Reddy M. Dry skin in the elderly: complexities of a common problem. Clin Dermatol. 2011;29:37-42.
Williams M-L, Payne S, Reeve J, Dona RK. Antidepressant medication in patients with advanced cancer - an observational study. Q J Med 2013;106:995-1001.
Wood GJ, Akiyama T, Carstens E, Oaklander AL, Yosipovitch G. An insatiable itch. J Pain. 2009;10:792-797.
Yosipovitch G, Bernhard JD. Clinical practice. Chronic pruritus. N Engl J Med. 2013;368:1625-1634.

Chapter 18

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition. Arlington, VA: American Psychiatric Association; 2013.
Annweiler C, Dursun E, Féron F, Gezen-Ak D, Kalueff AV, et al. ‘Vitamin D and cognition in older adults’: updated international recommendations. J Intern Med 2015;277:45-57.
Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones. E. Seminar: Alzheimer's disease. Lancet 2011;377: 1019-1031.
Bang J, Spina S, Miller BL. Frontotemporal dementia. Lancet 2015;386:1672-1682.
See comment in PubMed Commons belowBuckley JS, Salpeter SR. A risk-benefit assessment of dementia medications: systematic review of the evidence. Drugs Aging. 2015 [Epub ahead of print].
Cherubini A, Lowenthal DT, Paran E, Mecocci P, Williams LS, Senin U. Hypertension and cognitive function in the elderly. Dis Mon 2010;56:106-147.
Chodosh J, Petitti DB, Elliott M, Hays RD, Crooks VC, Reuben DB, et al. Physician recognition of cognitive impairment: evaluating the need for improvement. J Am Geriatr Soc. 2004; 52:1051-1059.
Chollet F. Pharmacologic approaches to cerebral aging and neuroplasticity: insights from the stroke model. Dialogues Clin Neurosci. 2013;15:67-76.
Declercq T, Petrovic M, Azermai M, Vander Stichele R, De Sutter AI, et al. Desai AK. Revitalizing the aged brain. Med Clin N Am 2011;95:463–475.
Dubois B, Feldman HH, Jacova C, et al. Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurology 2010; 9:1118-1127.
Dysken MW, Sano M, Asthana S, Vertrees JR, Pallaki M et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA 2014;311:333.
Factora RM, Tousi B. Don’t forget non-Alzheimer dementias. Cleavl Clin J Med 2014;81:243-253.
Gareri P1, De Fazio P, Manfredi VG, De Sarro G. Use and safety of antipsychotics in behavioral disorders in elderly people with dementia. Clin Psychopharmacol. 2014; 34:109-123.
Griffiths J, Hatch RA, Bishop J, Morgan K, Jenkinson C et al. An exploration of social and economic outcome and associated health-realated quality of life after critical illness in general intensive unit survivors: a 12 month follow-up study. Crit Care 2013;17:R100.
Grigoletto F, Zappala G, Anderson DW, Lebowitz, BD. Norms for the Mini-Mental State Examination in a healthy population. Neurology 1999; 53:315-320.
Harrison J. Cognitive approaches to early Alzheimer's disease diagnosis. Med Clin N Amer 2013;97:425-438. Jean L, Bergeron ME, Thivierge S, Simard M. Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr Psychiatry. 2010;18:281-296.
Huntley JD, Gould RL, Liu K, Smith M, Howard RJ. Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression. BMJ Open. 2015;5:e005247.
Jackson JC, Pandaharipande PP. Girard TD, Brummel NE, Thompson JL et al. Depression, post-traumatic stress disorder, and functional disability in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2014;5:369-379.
Kales HC, Kim HM, Zivin K, Valenstein M, Seyfried LS, et al. Risk of mortality among individual antipsychotics in patients with dementia. Am J Psychiatry. 2012;169:71-79.
Lannfelt L, Relkin NR, Siemers ER. Amyloid-ß-directed immunotherapy for Alzheimer’s disease. J Intern Med 2014;275:284–295.
Liew TM, Feng L, Gao Q, Ng TP, Yap P. Diagnostic utility of Montreal Cognitive Assessment in the fifth edition of Diagnostic and Statistical Manual of Mental Disorders: major and mild neurocognitive disorders. J Am Med Dir Assoc. 2015;16:144-148.
Lima LA. Progressive multifocal leukoencephalopathy: new concepts. Arq Neuropsiquiatr. 2013;71:699-702.
Littlejohns T, Henley VE, Lang IA, Angweiller A, Bouchet O el a. Vitamin D and the risk of dementia and Alzheimer disease. Neurology 2014;83:1-9.
LoGiudice D, Watson R. Dementia in older people: an update. Intern Med J 2014;44:1066-1073.
Massoodi N. Review: Cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment. Ann Intern Med. 2013;158:JC2-3.
Moyer VA. Screening for cgnitive impairment in older adults: U.S. Preventive Services Task Force recommendation. Ann Intern Med 2014; 160:791-797.
Ngo J, Holroyd-Leduc JM. Systematic review of recent dementia practice guidelines. Age Ageing 2015;44: 25-33.
O’Brien JT, Thomas A. Lancet 2015;386:1698-1706.
Pandharipande RP, Jackson GJC, Morandi A, Thompson JL, Pun BT et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013;369:1306-1316.
Patel BB, Holland NW. Mild cognitive impairment: Hope for stability, plan for progression. Cleveland Clin J Med 2012;79:857-864.
Robertson M, Seaton A, Whalle LJ. Can we reduce the risk of dementia? QJM. 2015;108:93-97.
Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, et al. Cognitive trajectories after postoperative delirium. N Engl J Med 2012;367:30-39.
Savica R, Petersen RC. Prevention of dementia. Psychiatr Clin N Am 2011;34:127–145.
Simpson JR. DSM-5 and Neurocognitive Disorders. J Am Acad Psychiatry Law 2014;42:2:159-164.
Swiger KJ, Manalac RJ, Blumenthal RS, Blaha MJ, Martin SS. Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects. Mayo Clin Proc. 2013;88:1213-1221.
Tay L, Lim WS, Chan M, Ali N, Mahanum S, et al. New DSM-V neurocognitive disorders criteria and their impact on diagnostic classifications of mild cognitive impairment and dementia in a memory clinic setting. Am J Geriatr Psychiatry. 2015;23:768-779.
Tjia J, Briesacher BA, Peterson D, Liu Q, Andrade SE, Mitchell SJ. Use of medications of questionable benefit in advanced dementia. JAMA Intern Med. 2014. doi:10.1001/ jamainternmed.2014.4103.
Tjia J, Briesacher BA, Peterson D, Liu Q, Andrade SE, Mitchell SL. Use of medications of questionable benefit in advanced dementia. JAMA Intern Med 2014;174:1763-1771.
Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM et al. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels. :  A randomized clinical trial. JAMA Intern Med. 2014;174:324-333.
Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2013;28;3:CD007726.
Yaffe C, Falvey CM, Hamilton N, Harris TB et al. Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitus. JAMA Intern Med. 2013;173:1300-1306.
Yoon CW, Shin JS, Kim HJ, Cho H, Noh Y, et al. Cognitive deficits of pure subcortical vascular dementia vs. Alzheimer disease: PiB-PET-based study. Neurology 2013;80; 569-573.

Chapter 19

Bellelli G, Morandi A, Davis DHJ, Mazzola P, Turco R et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014;43:496-502.
Bergmann MA, Murphy KM, Kiely DK, Jones RN, Marcantonio ER. A model for management of delirious postacute care patients. J Am Geriatr Soc 2005;53:1817-1825.
Burghaus L, Eggers C, Timmermann L, Fink GR, Diederich NJ. Hallucinations in neurodegenerative diseases. CNS Neurosci Ther 2012;2:149-159.
Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing 2010; 40:23-29.
Cole MG, McCusker J, Voyer P, Monette J, Champoux N, et al. The course of sybsyndromal delirium in oldewr long-term care residents. Am J Geriatr Psychiatry 2013;21:289-296.
Flaherty JH. The evaluation and management of delirium among older persons. Med Clin North America 2011;95:555-577.
Hakim SM, Othman AI, Naoum DO. Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly: a randomized trial. Anesthesiology 2012;116:987-997.
Khachiyants N, Trinkle D, Con SJ, Kim KY. Sundown syndrome in persons with dementia: an update. Psychiatry Investig. 2011; 8: 275-287.

Kosten TR, O'Connor PG. Management of drug and alcohol withdrawal. N Engl J Med. 2003;348:1786-1795.
Krishnan V, Leung LY, Caplan LR. A neurologist's approach to delirium: Diagnosis andmanagement of toxic metabolic encephalopathies. Eur J Intern Med 2014; 25:112-116.
Lin S-T, Chen C-C, Tsang H-Y, Lee C-S, Cheng K-D et al. Association between antipsychotic use and risk of acute myocardial infarction: a nationwide case-crossover study. Circulation. 2014;130:235-243.
Lundstrom M, Edlund A, Karlsson S, Brannstrom B, Bucht G, Gustafson Y, et al. A multifactorial intervention program reduces the duration of delirium, length of hospitalization, and mortality in delirious patients. J Am Geriatr Soc 2005;53:622-28.

McKenzie RB, Stewart MT, Bellantoni MF, Finucane TE. Bacteriuria in individuals who become delirious. Amer J Med 2014;127:255-257.
Leonard CE, Freeman CP, Newcomb CW, Bilker WB, Kimmel SE et al. Antipsychotics and the risks of sudden cardiac death and all-cause death: cohort studies in Medicaid and Dually-Elligible Medcaid-Medicare beneficiaries of five states. J Clin Exp Cardiolog 2013;Suppl 10:1-9.
Milisen K, Foreman MD, Abraham IL, DeGeest S, Godderis J, Vandermeulen E, et al. A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. J Am Geriatr Soc 2001;49:523-532.
Rockwood K, Cosway S, Carver D, Jarrett P, Stadnyk K, Fisk J. the risk of dementia and death after delirium. Age Ageing. 1999;28:551-556.
Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, et al. Cognitive trajectories after postoperative delirium. N Engl J Med 2012;367:30-39.
Schuckit MA. Recognition and management of withdrawal delirium (delirium tremens). N Engl J Med 2014;371:2109-2113.
Smith JP, Seirafi J. Delirium and Dementia. In: Marx JA, Hockberger RS, Walls RM: Rosen’s Emergeny Medicine. 8th Edition, 2014, Saunders:1398-1408.e2.
Teale EA, Young JB. Easily Missed? Subdural haematoma in the elderly. BMJ 2014;342g1682.
Theodorczuk A, Reynish E, Milisen K. Improving recognition of delirium in clinical practice: a call for action. BMC Geriatrics 2012,12:55.
Yoon HJ, Park KM, Choi WJ, Choi SH, Park JY, et al. Efficacy and safety of haloperidol versus atypical antipsychotic medications in the treatment of delirium. BMC Psychiatry. 2013;13:240.

Chapter 20

Belanger L, Belleville G, Morin CM. Management of hypnotic discontinuation in chronic insomnia. Sleep Med Clin 2009;4:583-592.
Berry SD, Lee Y, Cai S, Dore DD. Nonbenzodiazepine sleep medication use and hip fractures in LTCF residents. JAMA 2013;173:754-761.
Braun ME, Cines P, Gooneratne NS. Hypersomnia in older patients. Sleep Med Clin. 2012;7:365-378.
Buysse DJ, Germain A, Hall M, Monk TH, Nofzinger EA. A neurobiological model of insomnia. Drug Discov Today Models 2011;8:129-137.
Feinberg I, Maloney T, Campbell IG. Effects of hypnotics on the sleep EEG of healthy young adults: new data and psychopharmacologic implications J Psychiatr Res 2000;34:423-438.
Fernandez-Mendoza J, Vgontzas AN, Bixler EO, Singareddy R, Shaffer ML, Calhoun SL, Karataraki M, Vela-Bueno A, Liao D. Clinical and polysomnographic predictors of the natural history of poor sleep in the general population. Sleep. 2012;35:689-697.
Greenberg J, Goss JB. Therapies for insomnia and comorbid choronic obstructive pulmonary disease with a focus on Ramelteon (Rozerem). PT 2009; 34: 502–508.
Igarashi A, Zadzilka N, Shirahata M. Benzodiazepines and GABA-GABAA receptor system in the cat carotid body. Adv Exp Med Biol 2009; 648:169-175.
Jaussent I, Bouyer J, Ancelin ML, Berr C, Foubert-Samier A. Excessive sleepiness is predictive of cognitive decline in the elderly. Sleep 2012;35:1201-1207.
Kung S, Espinel Z, Lapid MI. Treatment of nightmares with prazosin: A systematic review. Mayo Clin Pro 2012;87:890-900.
Martin JL, Ancoli-Israel S. Sleep disturbances in long-term care. Clin Geriatr Med 2008;24:39-50.
Mitchell MD, Hehrman P, Perlis M, Umscheid CA. Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review. BMC Fam Pract 2012;13:40.
Mohsenin V. Portable monitoring for obstructive sleep apnea: The horse is out of the barn - Avoiding pitfalls. Amer J Med 2013;126:e1-3.
Morin CM, Benca R. Chronic insomnia. Lancet, 2012;379:1129-1141.
Neubauer DN. Current and new thinking in the management of comorbid insomnia. Am J Mana Care 2009;15 (Suppl):S24-S32.
Qaseem A, Holty J-E C, Owens DK, Dallas P, Starkey M, Shekelle P, for the Clinical Guidelines Committee of the American College of Physicians. Management of obstructive sleep apnea in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2013 doi:10.7326/0003-4819-159-7-201310010-00704.
Riegel B, Ratcliffe SJ, Weintraub WS, Sayers SL, Goldberg LR et al. Double jeopardy: the influence of excessive daytime sleepiness and impaired cognition on health-related quality of life in adults with heart failure. Eur J Heart Fail 2012;14:730-736.
Rodriguez JC, Dzierzesky JM, Alessi CA. Sleep problems in the plderly. Med Clin North Am. 2015;99:431-439.
Seibt J, Aton SJ, Coleman T, Dumoulin MC, Frank MG. The non-benzodiazepine hypnotic zolpidem impairs sleep-dependent cortical plasticity. Sleep 2008;31: 381–1391.
Shinno H, Ishikawa I, Yamanaka M, Usui A, Danjo S, Inami Y, et al. Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia. Sleep Med. 2011;12:578-583.
Tang NK, Lereya ST, Boulton H, Miller MA, Wolke D, et al. Nonpharmacological treatments of insomnia for long-term painful fonditions: a systematic review and meta-analysis of patient-reported outcomes in randomized fontrolled trials. Sleep. 2015. pii: sp-00773-14. [Epub ahead of print].
Tasali E, Leproult R, Ehrmann DA, Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci USA 2008;105:1044–1049.
Wade AG, Crawford G, Ford I, McConnachie A, Nir T, et al. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short-and long-term response. Curr Med Res Opin. 2011;27:87-98.
Webster LR, Cochella S, Dasgupta N et al. An analysis of the root causes for opioid-related overdose deaths in the United States. Pain Med 2001;12 (suppl 2):S26–S35.
Zee PC, Attarian H, Videnovic A. Circadian rhythm abnormalities.

Continuum (Minneap Minn). 2013;19 (1 Sleep Disorders):132–147.

Chapter 21

Banerjee S,

Hellier J, Dewey M, Romeo R, Ballard C, Baldwin R, et al

. Sertraline or mirtazapine for depression in dementia: a randomised, multicentre, double-blind, placebo-controlled trial. Lancet 2011;378:403-411.
Bolton M, Gunnell D, Turecki G. Suicide risk assessment and intervention in people with mental illness. BMJ 2015;351:h4978.

Bostwick MJ. A generalist's guide to treating patients with depression with an emphasis in using side effects to tailor antidepressant therapy. Mayo Clin Proc 2010;85:538-550.
Flaster M, Sharma A, Rao M. Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery. Top Stroke Rehabil. 2013;20:139-150.
Gallo JJ, Morales KH, HR, Raue PJ, Zee J et al. Bogner Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care. BMJ 2013;346:f2570.
Koenig AM, Butters MA. Cognition in late life depression: treatment considerations. Curr Treat Options Psychiatry. 2014;1:1-14.
Li G, Wang LY, Shofer JB, Thompson ML, Peskind ER et al. Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study. Arch Gen Pshychatry 2011;68:970-977. See comment in PubMed Commons below
Lohman MC, Mezuk B. Frailty and depression: comorbidity in the context of imperfect measurement. J Am Geriatr Soc. 2013;61:474-475.
Lydiatt WM, Bessette D, Schmid KK, Sayles H, Burke WJ. Prevention of depression with escitalopram in patients undergoing treatment for head and neck cancer: randomized, double-blind, placebo-controlled clinical trial. JAMA Otolaryngol Head Neck Surg. 2013;139:678-686.
Messinger-Rapport BJ. Geriatric updates; what parts of our practice to change, what to think about.’ Cleavland Clin J Med 2012;79:347-353.
Richard E, Reitz C, Honig LH, Schupf N, Tang MX, et al. Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol. 2013;70:374-382.
Robinson RG, Jorge RE, Moser DJ, Acion L, Solodkin A, et al. Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA 2008;299:2391-400.
Saczynski JS, Rosen AB, McCammon RJ, Zivin K, Andrade SE et al. Antidepressant use and cognitive secline: The Health and Retirement Study. Am J Med. 2015 Jan 30. pii: S0002-9343(15)00077-7. [Epub ahead of print].
Underwood M, Lamb SE, Eldridge S, Sheehan B, Slowther A-M, et al. Exercise for depression in elderly residents of care homes: a cluster-randomised controlled trial. Lancet 2013;382:41-49.
Unützers J, Park M. Older adults with severe, treatment-resistant depression. JAMA 2012;308:909-918.
Vieweg WV, Hasnain M, Howland RH, Hettema JM, Kogut C, et al. Citalopram, QTc interval prolongation, and torsade de pointes. How should we apply the recent FDA ruling? Am J Med 2012;125:859-868.
von Wolff A, Hölzel LP, Westphal A, Härter M, Kriston L. Selective serotonin reuptake inhibitors and tricyclic antidepressants in the acute treatment of chronic depression and dysthymia: a systematic review and meta-analysis. J Affect Disord 2013; 144:7-15.

Chapter 22

American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults. Recommendations abstracted from the American Geriatrics Society Consensus Statement on Vitamin D for prevention of falls and their consequences. J Am Geriatr Soc. 2013 Dec 18. doi: 10.1111/jgs.12631.
Barrett-Connor E, Nielson CM, Orwoll E, Bauer DC, Cauley JA; Osteoporotic Fractures in Med |Study Group. Epidemiology of rib fractures in older men: osteoporotic fractures in men (MeOS) prospective cohort study. BMJ 2010;340:c1069.
Brewer ES, Reznikov B, Liberman RF, Baker RA, Rosenblatt MS, David CA, Flacke S. Incidence and predictors of intracranial hemorrhage after minor head trauma in patients taking anticoagulant and antiplatelet medication. J Trauma. 2011;70:E1.
Cameron ID, Gillespie LD, Robertson MC, Murray GR, Hill KD, Cumming RG, Kerse N. Interventions for preventing falls in older people in care facilities and hospitals. Cochrane Database Syst Rev 2012;12: CD005465.
Chan WC, Yeung JW, Wong CS, Lam LC, Chung KF, et al. Efficacy of physical exercise in preventing falls in older adults with cognitive impairment: a systematic review and meta-analysis. J Am Med Dir Assoc. 2015;16:149-154.
de Vries OJ, Geeske Peeters MEE, Muller M, Knol DL, Danner SA, Bouter LM, Lips P. Multifactorial intervention to reduce falls in older people at high risk of recurrent falls. A randomized controlled trial. Arch Intern Med. 2010;170:1110-1117.
Dharmarajan TS, Norkus EP. Mild anemia and the risk of falls in older adults from LTCF and the community. J Am Med Dir Assoc 2004;5:395–400.
Garwood CL, Corbett TL. Use of anticoagulation in elderly patients with atrial fibrillation who are at risk for falls. Ann Pharmacother. 2008;42:523-532.
Haines TP, Hill A-M, Hill KD, McPhail S, Oliver D, et al. Patient education to prevent falls among older hospital inpatients. A randomized controlled trial. Arch Intern Med 2011;171:516-524.
Healey F, Oliver D, Milne A, Connelly JB. The effect of bedrails on falls and injury: a systematic review of clinical studies. Age Ageing 2008;37:368–378.
Hignett S, Sands G, Fray M, Xanthopoulou P, Healey F, Griffits P. Which bed designs and patient characteristics increase bed rail use? Age and Ageing 2013;42:531–535.
Ho P, Brooy BL, Hayes L, Lim WK. Direct oral anticoagulants in frail older adults: a geriatric perspective. Semin Thromb Hemost. 2015;41:389-394.
Lison MB, Bamious D-E, Martin F, Hopper A, Koohi N et al. Peripheral vestibular dysfunction is prevalent in older adults experiencing multiple non-syncopal falls versus age-matched non-fallers: a pilot study. Age Ageing 2014;43:38-43.
Manor B, Lough M, Gagnon MM, Cupples A, Wayne PM, Lipsitz LA. Functional benefits of tai chi training in senior housing facilities. J Am Geriatr Soc. 2014;62:1484-1489.
Mat S, Tan MP, Kamaruzzman SB, Ng CT. Physical therapies for improving balance and reducing falls risk in osteoarthritis of the knee: a systematic review. Age Ageing 2014; doi: 10.1093/ageing/afu112.
Maurer MS, Cohen S, Cheng H. The degree and timing of orthostatic blood pressure changes in relation to falls in LTCF residents. J Am Med Dir Assoc. 2004;5:233-238.
Moyer VA on behalf of the U.S. Preventive Services Task Force. Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2013;158: doi:10.7326/0003-4819-158-9-201305070-00603.
Ooi WL, Hossain M, Lipsitz LA. The association between orthostatic hypotension and recurrent falls in LTCF residents. Am J Med. 2000;108:106-111.
Rapp K, Becker C, Cameron ID, Konig HH, Buchele G. Epidemiology of falls in residential aged care: analysis of more than 70,000 falls from residents of bavarian LTCF. J Am Med Dir Assoc 2012;13:187. e1-6.
Robinovitch SN, Feldman F, Yang Y, Schonnap R, Leung PM, Sarraf T, et al. Video capture of the circumstance of falls in elderly people residing in long-term care: an observational study. Lancet 2013;381:47-54.
Romero-Ortuno R, Cogan L, Foran T, Kenny RA, Fan CW. Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people. J Amer Geriatr Soc 2011;59:655-665.
Scuteri A, Modestino A, Frattari A, Di Daniele N, Tesauro M. Occurrence of hypotension in older participants. Which 24-hour ABPM parameter better correlate with? J Geront Biol Sci Med Sci 2012;67:804-810.
van Diest M, Lamoth CJC, Stegenga J, Verkerke GJ, Postema K. Exergaming for balance training of elderly: state of the art and future developments. J NeuroEngineering Rehab 2013, 10:101.
Vu MQ, Weintraub N, Rubenstein IZ. Falls in the LTCF: are they preventable? J Am Med Assoc 2004;5:401-406.
Whitney SL, Wrisley DM, Marchetti GF, Furman JM. The effect of age on vestibular rehabilitation outcomes. Laryngoscope. 2002; 112: 1785–1790.

Chapter 23

Engbers MJ, Blom JW, Cushman M, Rosendaal FR, van Hylckama Vlieg A. The contribution of immobility risk factors to the incidence of venous thrombosis in an older population. J Thromb Haemost. 2014;12:290-296.
Wagner LM, Capezuti E, Brush BL, Clevenger C, Boltz M, Renz S. Contractures in frail LTCF residents. Geriatr Nurs 2008;29:259-266.
Wert DM, Talkowski JB, Brach J, VanSwearingen J. Characteristics of walking, activity, fear of falling, and falls in community-dwelling older adults by residence. J Geriatr Phys Ther 2010;33:41-45.

Chapter 24

Chapple CR, Kaplan SA, Mitcheson D, Klecka J, Cummings J, et al. Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β(3)-adrenoceptor agonist, in overactive bladder. Eur Urol. 2013;63:296-305.
Dubeau CE, Kraus SR, Griebling TL, Newman DK, Wyman JF. Effect of fesoterodine in vulnerable elderly subjects with urgency incontinence: a double-blind, placebo controlled trial. J Urol. 2014;191:395-404.
Fakih MG, Watson SR, Todd Greene M, Kennedy EH, Olmsted RN et al. Reducing inappropriate urinary catheter use: a statewide effort. Arch Intern Med. 2012;172:255-260.
Gibson W, Wagg A. New horizons: urinary incontinence in older people. Age Ageing 2014;43: 157-163.
Gormley EA, Lightner DJ, Burgio KL, Chai TC, Clemens JQ et al. Diagnosis and treamnent of overactive bladder (non-neurogenic) in adults: AUAQ/SUFU guideline. J Urol 2012;188:2456-2465.
Gould CV, Umscheid CA, Agarwal RK, Kuntz G, Pegues DA, Healthcare Infection Control Practices Advisory Committee (HICPAC). Guideline for prevention of catheter-associated urinary tract infections 2009. Atlanta (GA): Centers for Disease Control and Prevention (CDC); 2009. 67 p.
Isik AT, Celik T, Bozoglu E, Doruk H. Trospium and cognition in patients with late onset Alzheimer disease. J Nutr Health Aging. 2009;13:672-676.
Jahn P, Beutner K, Langer G. Types of indwelling urinary catheters for long-term bladder drainage in adults. Cochrane Database Syst Rev. 2012; 10; CD004997.
Kerdraon J, Robain G, Jeandel C, Mongiat Artus P, Gamé X et al. Impact on cognitive function of anticholinergic drugs used for the treatment of overactive bladder in the elderly. Prog Urol. 2014;24:672-681.
Leung FW, Schnelle JF. Urinary and fecal incontinence in LTCF residents. Gastroenterol Clin North Am. 2008;37:697-707.
Markland AD, Burgio KL, Whitehead WE, Richter HE, Wilcox CM, et al. Loperamide versus psyllium fiber for treatment of fecal incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial. Dis Colon Rectum. 2015;58:983-993.
Mishra A, Prapasrivorakul S, Gosselink MP, Gorissen KJ, Hompes R, et al. Sacral neuromodulation for persistent faecal incontinence after laparoscopic ventral rectopexy for high-grade internal rectal prolapse. Colorectal Dis. 2015, doi: 10.1111/codi.13125.
Negro CL, Muir GH. Chronic urinary retention in men: how we define it, and how does it affect treatment outcome. BJU Int. 2012;110:1590-15944.
Palka MA. Evidenced based review of recommendations addressing the frequency of changing long-term indwelling urinary catheters in older adults. Geriatr Nurs 2014;35:357-363.
Palka MA. Evidenced based review of recommendations addressing the frequency of changing long-term indwelling urinary catheters in older adults. Geriatr Nurs. 2014: S0197-4572(14)00154-2. [Epub ahead of print].
Shamlyan T, Wyman JF, Ramakrishnan R, Sainfort F, Kane RL. Systematic review: benefits and harms of pharmacologic treatment for urinary incontinence in women. Ann Intern Med 2012;156:861-874.
Skotnes LH, Mykletun A, Bakke AM, Kuhry E. Residual urine as a risk factor for lower urinary tract infection: a 1-year follow-up study in nursing homes. J Am Geriatr Soc. 2008;56:871-874.
Veenboer PW, Bosch JL. Long-term adherence to antimuscarinic therapy in everyday practice: a systematic review. J. Urol. 2014; 191:1003-1008.
Wyndaele JJ, Schneider T, MacDiarmid S, Scholfield D, Arumi D. Flexible dosing with fesoterodine 4 and 8 mg: a systematic review of data from clinical trials. Int J Clin Pract. 2014;68:830-840.

Chapter 25

Brienza D, Kelsey S, Karg P, Allegretti A, Olson M et al. A randomized clinical trial on preventing decubitus ulcers with wheelchair seat cushions. J Am Geriatr Soc. 2010; 58: 2308–2314.
Cai S, Rahman M, Intrator O. Obesity and pressure ulcers among nursing home residents. Med Care. 2013;51:478-486.
Campbell N, Campbell D. A retrospective, quality improvement review of maggot debridement therapy outcomes in a foot and leg ulcer clinic. Ostomy Wound Manage 2014;60:16-25.
Eisenbeiß W, Siemers F, Kramer A. Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients. Int J Burns Trauma. 2012;2:71-79.
Gottrup F, Jorgensen B. Maggot debridement: an alternative method for debridement Eplasty. 2011; 11: e33.
Health Quality Ontario. Negative pressure wound therapy.

An evidence-based analysis. Ont Health Technol Assess Ser. 2006;6:1–38.
Kwon R, Janis JE. Pressure ulcers. In: PC Neligan. Plastic Surgery, 3d Ed, 2013, Elsevier, 2013:352-382.e11.
Lebwohl MG, Heymann WR, Berth-Jones J, Coulson I. Treatment of Skin Disease: Comprehensive Therapeutic Strategies, Fourth Edition, 2014;52:167-171.
Mandal A. Role of topical negative pressure in pressure ulcer management. J Wound Care 2007;16:33-35.
Moore ZE, Webster J. Dressings and topical agents for preventing pressure ulcers. Cochrane Database Syst rev 2013;8:CD009982.
Nicolas B, Moiziard AS, Barrois B, Ribnik P, Colin D et al. Which medical devices and/or local drug should be curatively used, as of 2012, for PU patients? How can granulation and epidermidalization be promoted? Developing French guidelines for clinical practice. Ann Phys Rehab Med, 2012;55:489-497.
Qaseem A, Humphrey LL, Forciea MA, Starkey M, Denberg TD; Clinical Guidelines Committee of the American College of Physicians. Treatment of pressure ulcers: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2015;162:370-379.
Quaseem A, Mir TP, Starke M, Denberg TD. Clinical Guidelines Committee of the American College of Physicians. Risk assessment and prevention of pressure ulcers: A clinical practice guideline from the American College of Physicians. Ann Intern Med 2015; 162:359-369.
Reddy M, Gill SS, Kalkar SR, Wu W, Anderson PJ, Rochon PA. Treatment of decubitus ulcers: a systematic review. JAMA 2008;300:2647-2662.
Reddy M, Gill SS, Wu W, Kalkar SR, Rochon PA. Does this patient have an infection of a chronic wound? JAMA 2012;307:605-611.
Rennert R, Golinko M, Yan A, Flattau A, Tomic-Canic M, et al. Developing and evaluating outcomes of an evidence-based protocol for the treatment of osteomyelitis in Stage IV pressure ulcers: a literature and wound electronic medical record database review. Ostomy Wound Manage. 2009;55:42-53.
Sernekos LA. Nutritional treatment of pressure ulcers: what is the evidence? J Am Assoc Nurse Pract. 2013;25:281-288.

Steenvoorde P, Jacobi CE, Van Doorn L, Oskam J. Maggot debridement therapy of infected ulcers: patient and wound factors influencing outcome - a study on 101 patients with 117 wounds. Ann R Coll Surg Engl. 2007;89:596-602.
Thomas DR, Rodeheaver GT, Bartolucci AA, Franz RA, Sussman C et al. Pressure ulcer scale for healing: derivation and validation of the PUSH tool. The PUSH Task Force. Adv Wound Care 1997;10:96-101.
White-Chu EF, Flock P, Struck B, Aronson L. Decubitus ulcers in long term care. Clin Geriatric Med 2011; 27:241-258.

Chapter 26

Clegg A, Young J, Iliff S, Olde Rickkert M, Rockwood K. Frailty in elderly people. Lancet 2013;381:752-762.
Garre-Olmo J, Calvo-Perxas L, Lopes-Pousa S, de Gracia Blanco M, Vilalta-Franch J. Prevalence of frailty phenotypes and risk of mortality in a community-dwelling elderly cohort. Age Ageing 2013;42:46-51.

Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14: 392–397.
Morley JE. Frailty: A time for action. Eur Geriat Med 2013;4:215-216.
Peel NM, Kuys SS, Klein K. Gait speed as a measure in geriatric assessment in clinical settings: a systematic review. J Gerontol A Biol Sci Med Sci. 2013;68:39-46.
Pilotto A, Rengo F, Marchionni N, Sancario D, Fontana A, et a. Comparing the prognostic accuracy for all-cause mortality of frailty instruments: a multicentre 1-year follow-up in hospitalized older patients. PLoS One 2012;7(1):e29090.
Regional Health Council. Frailty in elderly people. Florence (Italy): Regione Toscana, Consiglio Sanitario Regionale; 2013:1-59.
Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173:489-495.
Rockwood K, Theou O, Mitnitski A. What are frailty instruments for? Age and Ageing 2015;44:545-547.
Romero-Ortuno R, O’Shea D. Fitness and frailty: opposite ends of a challenging continuum! Will the end of age discrimination make frailty assessments an imperative? Age Ageing 2013; 42: 279-280.
Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M et al. Gait speed and survival in older adults. JAMA 2011;305:50–58.
Taekema DG, Gussekloo J, Westendorp RGJ, de Craen AJM, Maier AB. Predicting survival in oldest old people. Am J Med 2012; 125: 1188–1194.
Theou O, Stathokostas L, Roland KP, Jakobi JM, Patterson C, Vandervoort AA, Jones GR. The effectiveness of exercise interventions for the management of frailty: a systematic review. J Aging Res 2011; doi: 10.4061/2011/569194.
Toots A, Rosendahl E, Lundin-Olsson L, Nordström P, Gustafson Y, et al. Usual gait speed independently predicts mortality in very old people: a population-based study. J Am Med Dir Assoc. 2013;14:529.e1-6.

Chapter 27

Hoover RM, Polson M. Detecting elder abuse and neglect: assessment and intervention. Am Fam Physician. 2014;89:453-460.
Lachs MS, Pillemer KA. Elder abuse. N Engl J Med 2015;373:1947-1956.
Loewenstein A. Elder abuse and neglect-'old phenomenon': new directions for research, legislation, and service developments. (2008 Rosalie S. Wolf Memorial Elder Abuse Prevention Award-International Category Lecture). J Elder Abuse Negl 2009; 21:278-287.
McDonald L, Thomas C. Elder abuse through a life course lens. Int Psychogeriatr 2013;25:1235-1243.

Chapter 28

Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM et al. 2011 ACCCF/AHA focused update incorporated into the ACC/AHA guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction. Circulation 2011;123:e426-e579.
Bavishi C, Panwar S, Messerli FH, Bangalore S. Meta-analysis of comparison of the newer oral P2Y12 inhibitors (prasugrel or ticagrelor) to clopidogrel in patients with non-ST-elevation acute coronary syndrome.

Am J Cardiol. 2015;116:809-817.
Gan XD, Wei BZ, Fang D, Fang Q, Li KY, et al. Efficacy and safety analysis of new P2Y12 inhibitors versus clopidogrel in patients with percutaneous coronary intervention: a meta-analysis. Curr Med Res Opin. 2015 Sep 24:1-31.
Lincoff AM. Managing acute coronary syndromes: decades of progress. Cleavl Clin J Med 2014;81:233-242. Serebruany VL, DiNicolantonio JJ. Viewpoint: mismatch between the European and American guidelines on oral antiplatelet P2Y12 inhibitors after acute coronary syndromes. Thromb Haemost. 2013;110:5-10.
Mehta RH, Rathore SS, Radford MJ, Krumholz EM. Acute myocardial infarction in the older adult: differences by age. J Am Coll Cardiol 2001;38:736-741.
Saunderson CED, Brogan RA, Simms AD, Sutton G, Battinin PD et al. Acute coronary syndrome management in older adults: guidelines, temporal changes and challenges. Age and Ageing 2014;43:450–455.
Stern S, Behar S, Leor J, Harpaz D, Boyko V, Gottlieb S. Presenting symptoms, admission electrocardiogram, management, and prognosis in acute coronary syndromes: differences by age. Am J Geriatr Cardiol 2004;13:188-196.
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, et al. Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2551-2567.
White HD, Westerhout CM, Alexander KP, Roe MT, Winters KJ, et al. Frailty is associated with worse outcomes in non-ST-segment elevation acute coronarysyndromes: Insights from the targeted platelet inhibition to clarify the optimal strategy to medically manage acute coronary syndromes (TRILOGY ACS) trial. Eur Heart J Acute Cardiovasc Care. 2015, pii: 2048872615581502.

Chapter 29

Cantillion DJ. Evaluation and management of premature ventricular complexes. Clevel Clin J Med 2013;80:377-387.
Chow GV, Marine JE, Fleg JL. Epidemiology of arrhythmias and conduction disorders in older adults. Clin Geriatr Med 2012;28:539-553.
European Heart Rhythm Association, Heart Rhythm Society, Zipes DP, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 2006; 48:e247.
Giles K, Green MS. Workup and management of patients with frequent premature ventricular contractions. Can J Cardiol. 2013;29:1512-1515.
Lubart E.

QT interval disturbances in hospitalized elderly patients. Isr Med Assoc J 2009;11:147-150.
Teo KK, Yusuf F, Furberg CD. Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. An overview of results from randomized controlled trials. JAMA 1993;270:1589-1595.

Chapter 30

Nolan JP, Soar J, Perkins GD. Cardiopulmonary resuscitation. BMJ 2012;345:e6122.
Weston C, Aldalati O. Cardiorespiratory arrest. Medicine 2013;41:59-63.

Chapter 31

Blain H, Bonnafous M, Grovalet H, Jonquet O, David M. The table maneuver: a procedure used with success in four cases of unconscious choking older subjects. Amer J Med 2010;123:1150e7-29.
Cabre M, Serra-Prat M, Palomera E, Almirall J, Pallares R, Clavé P. Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia. Age Ageing, 2010; 39:39–45.
Reynolds JH, Banerjee AK. Imaging pneumonia in immunocompetent and immunocompromised individuals. Curr Opin Pulm Med. 2012;18:194-201.
Simons FER, Sheikh A. Anaphylaxis: the acute episode and beyond. BMJ 2013;346:f602.
Smith HA, Lee SH, O'Neill PA, Connolly MJ. The combination of bedside swallowing assessment and oxygen saturation monitoring of swallowing in acute stroke: a safe and humane screening tool. Age Ageing 2000; 29: 495–499.
Smith TJ. Symptom management in the older adult: 2015 update. Clin Geriatr Med 2015;31:155-175.

Chapter 32

Dhami s, Panesar SS, Roberts G, Muraro A, et al. Management of anaphylaxis: a systematic review. Allergy. 2013 Nov 20. doi: 10.1111/all.12318. [Epub ahead of print].
Sclar DA, Lieberman PL. Anaphjylaxis: underdiagnosed, underreported, and undertreated. Amer J Med 2014;127:S1-S5.

Chapter 33

Ahmed I, Gerner E. Safety of arthrocenthesis and joint injection in patients receiving anticoagulation at therapeutic levels. Am J Med 2012;125:265-269.
Baillargeon J, Holmes HM, Lin Y-L Raji MA, Sharma G, Kuo Y-F. Concurrent use of warfarin and antibiotics and the risk of beeding in older adults. Amer J Med 2012;125: 183-189.
Bauersachs RM. Managing venous thromboembolism with novel oral anticoagulants in the elderly and other high-risk patient groups. Eur J Intern Med 2014;25:600-606.
Bhutia S, Wong PF. Once versus twice daily low molecular weight heparin for the initial treatment of venous thromboembolism. Cochrane Database Syst Rev. 2013;7:CD003074.
Brotman DJ, Jaffer AK. Prevention of venous thromboembolism in the geriatric patient. Cardiol Clin 2008;26:221-234.
Carrier M, Khorana AA, Moretto P, Le Gal G, Karp R, Zwicker JI. Lack of evidence to support thromboprophylaxis in hospitalized medical patients with cancer. Am J Med. 2014;127:82-86.
Che DH, Cao JY, Shang LH, Man YC, Yu Y. The efficacy and safety of low-molecular-weight heparin use for cancer treatment: A meta-analysis. Eur J Intern Med 2013;24:422-439.
Connors JM. Extended treatment of venous thromboembolism. N Engl J Med 2013;368:767-769.
Connors JM. Prophylaxis against venous thromboembolism in ambulatory patients with cancer. N Engl J Med 2014;370:2515-2519.
Decousus H, Quere I, Presles E, Becker F, Barrelier MT et al. Superficial venous thrombosis and venous thromboembolism: a large, prospective epidemiologic study. Ann Intern Med 2010;152:218-224.
Deedwania PC. New oral anticoagulants in elderly patients with atrial fibrillation. Am J Med 2013;126:289-296.
Deitcher SR, Kessler CM, Merli G, Rigas JR, Lyons RM, Fareed J. Secondary prevention of venous thromboembolic events in patients with active cancer: enoxaparin alone versus initial enoxaparin followed by warfarin for a 180-day period. Clin. Appl. Thromb. Hemost. 2006;12;389-396.

Del Conde I, Halperin JL. Ineligibility for anticoagulation in patients with atrial fibrillation. Am J Med. 2013;126:105-111.
Diaz AH, Rodgers GM, Gilreath JA. Enoxaparin once daily vs. twice daily dosing for the treatment of venous thromboembolism in cancer patients: a literature summary. J Oncol Pharm Pract. 2012;18:264-270.
Donze J, Clair C, Hug B, Rodondi N, Waeber G, Cornuz J, Aujesky D. Risk of falls and major bleeds in patients on oral anticoagulation therapy. Amer J Med 2012;125:773-78.
Douma RA, le Gal G, Sohne M, Rigini M, Kamphouisen PW, Perrier A et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ 2012;340:c1475.
Eikelboom JW, Connolly SJ, Brueckmann M, Granger CB, Kappelein AP et al. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med 2013; 369:1206-1214.
Eisele R, Melzer N, Bramlage P. Perioperative management of anticoagulation. Chirurg. 2014;85:513-519.
Estève E, Armingaud P, Martin L. Cutaneous and subcutaneous hematomas observed in dermatology: 17 cases. Ann Dermatol Venereol. 2004;131(6-7 Pt 1):555-558.
Fallouh N, McGuirk HM, Flanders SA, Chopra V. Peripherally inserted central catheter-associated deep vein thrombosis: a narrative review. Amer J Med 2015;128:722-738.
Farge D, Debourdeau P, Beckers M, Baglin C, Bauersachs RM, et al. International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. J Thromb Haemost. 2013;11:56-70.
Galus S.

Heparins for preventing venous thromboembolism in general medical wards: evidence and guidelines.

Internal Medicine Journal 2014;44:1051-1054.
Garcia DA, Baglin TP, Weitz JI, Sammama MM. Parenteral anticoagulants. Chest. 2012; 141(2-suppl): e24S–e43S.
Harper P, Young L, Merriman E. Bleeding risk with dabigatran in frail elderly. N Engl J Med 2012;366:9.
Holbrook A, Schulman S, Witt DM, Vandvik PO, Fish J, Kovacs MJ. Evidence-based management of anticoagulant therapy. Anticoagulant Therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141(2_suppl):e152S-e184S.
Kahn SR, Ducruet T, Lamping DL, Arsenault L, Miron MJ, et al. Prospective evaluation of health-related quality of life in patients with deep venous thrombosis. Arch Intern Med. 2005;165:1173-1178.
Kahn SR, Lim W, Dunn AS Cushman M, Dentali F, et  al. Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest 2012; 141:e195S–226S.
Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ; American College of Chest Physicians. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133(suppl 6):454S–545S.
Khan MS, Sipra QR, Asawaeer M, Riaz IB. The Role of Thromboprophylaxis in Patients with Permanent Immobility. Amer J Med 2014 [in press].
Linkins LA, Dans AL, Moores LK, Bona R, Davidson BL, et al. Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141(2 Suppl):e495S-530S.
Lippi G, Bonfanti L, Saccenti C, Cervellin G. Causes of elevated D-dimer in patients admitted to a large urban emergency department. Eur J Intern Med 2014;25:45–48.
Masuda EM, Kistner RL, Musikasinthorn C, Liquido F, Geling O, He Q. The controversy of managing calf vein thrombosis. Vasc Surg. 2012;55:550-561.
Merli G, Spiro TE, Olsson CG, Abildgaard U, Davidson BL, et al. Subcutaneous enoxaparin once or twice daily compared with intravenous unfractionated heparin for treatment of venous thromboembolic disease. Ann Intern Med. 2001;134:191-202.
Patel A, Panikkath R, Fenire M, Gadwala S, Nugent K. Indications and Appropriateness of Inferior Vena Cava Filter Placement. Am J Med Sci 2015;349:212–216.
Pautas E, Peyron I, Bouhadiba S, Golmard J-L, Gouronnec A, et al. Reversal of overanticoagulation in very elderly hospitalized patients with an INR above 5.0: 24-hour INR response after vitamin K administration. Amer J Med 2011;124:527-533.
Pebanco GD, Kaiser SA, Haines ST. New pharmacologic methods to prevent venous thromboembolism in older adults: a meta-analysis. Ann Pharmacother 2013; 47; 605-616.
Pertoldi S. Di Benedetto P.

Shoulder-hand syndrome after stroke. A complex regional pain syndrome. Eura Medicophys 2005;41:283-292.
Pierfranceschi G, Donadini MP, Dentali F, Ageno W, Narazzi M, et al. The short- and long-term risk of venous thromboembolism in patients with acute spinal cord injury: a prospective cohort study. Thromb Haemost 2013;109:34-38.
Prandoni P, Barbar S. Milan M, Vedovetto V, Pesavento R. The risk of recurrent thromboembolic disorders in patients with unprovoked venous thromboembolism: New scenarios and opportunities. Eur J Intern Med 2014;25:25-30.
Sharma M, Cornelius VR, Patel J P, Davies JG, Molokhia M. Efficacy and harms of direct oral anticoagulants in the elderly for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism: systematic review and meta-analysis. Circulation 2015;132:194-204.
Squizzato A. Prevention of venous thromboembolism and persistent vegetative state: A medical and an ethical issue. Eur J Intern Med 2008;19:386.
Trujillo-Santos J, Schellong S, Falga C, Zorrilla V, Gallego P, Barrón M et al. Low-molecular-weight or unfractionated heparin in venous thromboembolism: the influence of renal function. Amer J Med 2013; 126: 425-434.
Verdi M, Ghanem-Zoubi NO, Zidan R, Yurin V, Bitterman H. Venous thromboembolism and the utility of the Padua Prediction Score in patients with sepsis admitted to internal medicine departments. J Thromb Haemost 2013;11:467-473.
Verhamme P, Bounameaux H. Direct oral anticoagulants for acute venous thromboembolism. Closing the Circle? Circulation 2014;129:725-727. Stein PD, Matta F. Vena cava filters in unstable elderly patients with acute pulmonary embolism. Amer J Med 2014; 127:222-225.
Yusen RD, Hull RD, Schellong SM, Tapson VF, Monreal M, et al. Impact of age on the efficacy and safety of extended-duration thromboprophylaxis in medical patients. Subgroup analysis from the EXCLAIM randomised trial. Thromb. Haemost. 2013;110; 1152-1163.
Zhou M, Hu Y, Long X, Liu D, Liu L, et al. Diagnostic performance of magnetic resonance imaging for acute pulmonary embolism: a systematic review and meta-

Chapter 34

al-Furaih TA, McElnay JC, Elborn JS, Rusk R, Scott MG, et al. Sublingual captopril-a pharmacokinetic and pharmacodynamic evaluation. Eur J Clin Pharmacol. 1991;40:393-398.
Cunningham FE, Baughman VL, Peters J, Laurito CE. Comparative pharmacokinetics of oral versus sublingual clonidine. J Clin Anesth. 1994;6:430-433.
Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013; 44:870-947.
Kaplan NM, Victor RG. Chapter 8: Hypertensive Crises. In: Kaplan's Clinical Hypertension, 10th Ed, Lippincott, Williams & Wilkins, Philadelphia 2010. p.274.
Kaya A, Tatlisu MA, Kaplan Kaya T, Yildirimturk O, Gungor B, et al. Sublingual vs. oral captopril in hypertensive crisis. J Emerg Med. 2015; doi: 10.1016/j.jemermed. 2015.07.017.
Peacock WF 4th, Hilleman DE, Levy PD, Rhoney DH, Varon J. A systematic review of nicardipine vs labetalol for the management of hypertensive crises. Am J Emerg Med. 2012;30:981-993.
Rosei EA, Salvetti M, Farsang C. European Society of Hypertension Scientific Newsletter: treatment of hypertensive urgencies and emergencies. J Hypertens 2006; 24:2482-2485.

Chapter 35

Abuelo GJ. Normotensive ischemic acute renal failure. N Engl J Med 2007;357:797-805.
Vincent J-L, De Backer D. Circulatory shock. N Engl J Med 2013;369:1726-1734. Dinsen S, Baslund B, Klose M, Rasmussen AK, Friis-Hansen L, et al. Why glucocorticoid withdrawal may sometimes be as dangerous as the treatment itself. Eur J Intern Med 2013;24:714-720.
Volbeda M, Wetterslev J, Gluud C, Zijlstra JG, van der Horst IC, et al. Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis. Intensive Care Med. 2015;41:1220-1234.

Chapter 36

Alfie J. Utility of home blood pressure monitoring to evaluate postprandial blood pressure in treated hypertensive patients.

Ther Adv Cardiovasc Dis. 2015;9:133-139.
See comment in PubMed Commons belowBuckley JS, Salpeter SR. A risk-benefit assessment of dementia medications: systematic review of the evidence. Drugs Aging. 2015 [Epub ahead of print]

Cooke J, Carew S, O'Connor M, Costelloe A, Sheehy T, Lyons D. Sitting and standing blood pressure measurements are not accurate for the diagnosis of orthostatic hypotension. QJM 2009;102:335-339.
Figuero JJ, Basford JR, Low PA. Preventing and treating orthostatic hypotension: as easy as A, B, C. Cleveland Clinic J Med 2010;77:298-306.
Flammang D, Church TR, De Roy L, Blanc JJ, Leroy J, Mairesse GH, et al. Treatment of unexplained syncope: a multicenter, randomized trial of cardiac pacing guided by adenosine 5’-triphosphate testing. Circulation 2012;125:31-36.
Frith J, Newton JL, Parry SW. Measuring and defining orthostatic hypotension in the older person. Age and Ageing 2014;43:168–170.
Galizia G. Abete P, Testa G, Vecchio A, Corr T, Nardone A. Counteracting effect of supine leg resistance exercise on systolic orthostatic hypotension in older adults. J Am Geriatr Soc 2013;61:1152-1157.
Izcovich A, González Malla C, Manzotti M, Catalano HN, Guyatt G. Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. Neurology. 2014;83:1170-1177.
Jang AL, Hwang SK, Kim DU. Effects of guar gum ingestion on postprandial blood pressure in older adults. J Nutr Health Aging. 2015;19:299-304.
Jian ZJ, Zhou BY. Efficacy and safety of acarbose in the treatment of elderly patients with postprandial hypotension. Chin Med J 2008;121:2054-2059.
Khadilkar SV, Yadav RS, Jagiasi KA. Are syncopes in sitting and supine positions different? Body positions and syncope: a study of 111 patients. Neurol India. 2013; 61:239-243.
Lagro J, Meel-van den Abeelen A, de Jong DL, Schalk BW, Olde Rikkert MG et al. Geriatric hypotensive syndromes are not explained by cardiovascular autonomic dysfunction alone. J Gerontol A Biol Sci Med Sci 2013;68:581–589.
Loavenbruck A, Sandroni P. Neurogenic orthostatic hypotension: roles of norepinephrine deficiency in itsvCauses, its treatment, and future research directions. Curr Med Res Opin. 2015 Sep 1:1-41. [Epub ahead of print]
Logan IC, Witham MD. Efficacy of treatments for orthostatic hypotension: a systematic review. Age and Ageing 2012;41: 587–594.
Marrsiona VK, Fletcherb A, Parry SW. The older patient with syncope: practicalities and controversies. Intern J Cardiol 2012;155:9-13.
Moya A, Sutton R, Ammirati F, Blanc JJ, Brignole M, Dahm JB, et al. Guidelines for the diagnosis and management of syncope (version 2009): the Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC). Eur Heart J 2009;30:2631-2671.
Ong AC, Myint PK, Potter JF. Pharmacological treatment of postprandial reductions in blood pressure: a systematic review. J Am Geriatr Soc. 2014;62:649-661.
Ooi WL, Hossain M, Lipsitz LA. The association between orthostatic hypotension and recurrent falls in LTCF residents. Am J Med. 2000;108:106-111.
Romme JJ, Reitsma JB, Black CN, Colman N, Scholten RJ, Wieling W, Van Dijk N. Drugs and pacemakers for vasovagal, carotid sinus and situational syncope. Cochrane Database Syst Rev 2011;10:CD004194.
Roussanov O, Estacio G, Caouno M, Wilson SJ, Kovedsy C, Jarmuklin. New-onset syncope in older adults: focus on age and etiology. Am J Geriatr Cardiol 2007;16:287-294.
Shibao C, Okamoto LE, Gamboa A, Yu C, Diedrich a, Raj SR, Robertson D, Biaggioni I. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension 2010;56:847-851.
Task Force for the Diagnosis and Management of Syncope, European Society of Cardiology, European Heart Rhythm Association, et al. Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J 2009;30:2631.

Chapter 37

Eggers SD, Bundrick JB, Litin SC. Clinical pearls in neurology. Mayo Clin Proc 2012;87:280-285.
Humphriss RL, Baguley DM, Sparkes V, Peerman SE, Moffat DA. Contraindications to the Dix-Hallpike manoeuvre: a multidisciplinary review. Int J Audiol. 2003;42:166-173.
Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke 2009;50:3504-3510.
Ludman H. Vertigo and imbalance. BMJ 2014;348:g283. Kim J-S, Zee DS. Benign paroxysmal positional vertigo. N Engl J Med 2014;370:1138-1147.
Newnman-Tocker DE, Cannon LM, Stofferahn ME, Rothman RE, Hsieh YH, Zee DS. Imprecision in patient reports of dizziness symptom quality: a cross-sectional study conducted in an acute care setting. Mayo Clin Proc 2007;82:1329-1240.

Chapter 38

Abuelo JG. Normotensive ischemic acute renal failure. N Engl J Med 2007;357:797-805.
Bellomo R, Kellum Jam Ronco C. Acute kidney injury. Lancet 2012;380:756-766.
Goldman L, Schafer AI. Goldman's Cecil Medicine, 24th Ed, Saunders, 2012;122:756-761.
Gotfried J, Wiesen J, Raina R, Nally JVJr. Finding the cause of acute kidney injury: Which index of fractional excretion is better? Cleveland Clinic J Medicine 2012;79:121-129.

Chapter 39

Angus-Leppan H. First seizures in adults. BMJ 2014;348:g2470.
de Haan GJ, van der Geest P, Doelman G, Bertram E, Edelbroek P. A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations. Epilepsia. 2010;51:478-482.
Jankovic SM, Dostic M. Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects. Expert Opin Drug Metab Toxicol 2012;8:81-91.
Krumholz A, Wiebe S, Gronseth G, Shinnar S, Levisohn P, Ting T, et al. Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society. Practice Parameter: evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2007; 69:1996–2007.
Lunde JL, Nelson RE, Storandt HF. Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy. Pharmacotherapy 2007;27:1202-1205.
Malaty W, Stigleman S. Antiepileptic drug level monitoring. Am Family Physician 2008; 78:385-386.
Meierkord H, Boon P, Engelsen B, Göcke K, Shorvon S, et al. EFNS guideline on the management of status epilepticus in adults. Eur J Neurol. 2010;17:348-355.
Nair PP, Kalita J, Misra UK. Status epilepticus: why, what, and how. J Postgrad Med 2011;57:242–252.
Poolos NP, Warner LN, Humphreys SZ, Williams S. Comparative efficacy of combination drug therapy in refractory epilepsy. Neurology 2012;78:62-68.
Schmidt D, Schachter SC. Drug treatment of epilepsy in adults. BMJ. 2014;348:g254.
Wermeling DP. Intranasal delivery of antiepileptic medications for treatment of seizures. Neurotherapeutics. 2009;6:352-358.

Chapter 40

Di Perri C, Thibault A, Heine L, Soddu A, Demertzi A, et al. Measuring consciousness in coma and related states. World J Radiol 2014;6:589-597.
Dolce G, Arcuri F, Carozzo S, Cortese MD, Greco P et al. Care and neurorehabilitation in the disorder of consciousness: a model in progress.

Scientific World Journal. 2015; doi: 10.1155/2015/463829.
Gosseries O, Bruno MA, Chatelle C, Vanhaudenhuyse A, Schnakers C, et al. Disorders of consciousness: what's in a name? NeuroRehabilitation. 2011;28:3-14.
Luauté J, Maucort-Boulch D, Tell L, Quelard F, Sarraf T, et al. Long-term outcomes of chronic minimally conscious and vegetative states. Neurology. 2010;75:246-252.
Turner-Stokes L, Bassett P, Rose H, Ashford S, Thu A. Serial measurement of Wessex Head Injury Matrix in the diagnosis of patients in vegetative and minimally conscious states: a cohort analysis.

BMJ Open. 2015;5:e006051.
Vitaz TW. Management of head injuries. In: Bope & Kellerman: Conn's Current Therapy 2013, 1st ed.
Wijdicks EFM. Cranford RE. Clinical diagnosis of prolonged states of impaired consciousness in adults. Mayo Clin Proc 2005;80:1037-1104.
Young GB. Neurologic prognosis after cardiac arrest. N Engl J Med 2009; 361:605-611.

Chapter 41

Davis SM, Donnan GA. Secondary prevention after ischemic stroke or transient ischemic attack. N Engl J Med 2012;366:1914-1922.
Giannopoulos S, Katsanos AH, Tsivgoulis G, Marshall RS. Statins and cerebral hemodynamics. J Cereb Blood Flow Metab. 2012;32:1973-1976.
Grotta JC. Carotis stenosis. N Engl J Med 2013; 369:1143-1150.
Ishida K, Raser-Schramm JM, Wilson CA, Kasner SE, MullenMmT et al. Convergent validity and interrater reliability of estimating the ABCD2 score from medical records. Stroke 2013;44:803-805.
Merwick A, Werring D. Posterior circulation ischaemic stroke. BMJ 2014;348:g3175.
Morgenstern LB, Hemphill JC 3rd, Anderson C, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2010; 41:2108-2129.
Taccone FS, Scolletta S, Franchi F, Donadello K, Oddo M. Brain perfusion in sepsis. Curr Vasc Pharmacol. 2013;11:170-186.
Tai Waimei A, Albers GW. Secondary prevention of atherothrombotic or cryptogenic stroke. Circulation 2014;129:527-531.
Wang Y, Wang Y, Zhao X, Liu L, Wang D, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369:11–19.

Chapter 42

Grunkemeier DMS, Cassara JE, Dalton CB, Drossman DA. The Narcotic Bowel Syndrome: Clinical Features, Pathophysiology and Management. Clin Gastroenterol Hepatol. 2007;5:1126-1132.
Gurusamy KS, Davidson BR. Gallstones. BMJ 2014;348:g2669.
Jamil KM, Jacomb-Hood JH, Fidler HM. Investigating the frail elderly patient with lower bowel symptoms: what do we do now and can we improve? Clin Med 2013;13:37-41.
Manterola C, Vial M, Moraga J, Astudillo P. Analgesia in patients with acute abdominal pain. Cochrane Database Syst Rev. 2011;(1):CD005660.
Murphy MF, Waters JH, Wood EM, Yazer MH. Transfusing blood safely and appropriately. BMJ 2013; 347 doi:
Vadera R, Sherbino J. Do opioids affect the clinical evaluation of patients with acute abdominal pain? Ann Emerg Med. 2009;54:126-127.
Wiersemma UB, Bruno MJ, Tjwa ETTL. On colonoscopy in acute colonic pseudo obstruction. Eur J Intern Med 2014;24:e86–e87.

Chapter 43

Dvir Y, Smallwood P. Serotonin syndrome: a complex but easily avoidable condition. Gen Hosp Psychiatry 2008;30:284-287.
Gillman PK. Neuroleptic malignant syndrome: Mechanisms, interactions, and causality. Mov Disord 2010;25:1780-1790.
Greenier E, Lukyanova V, Reede L. Serotonin syndrome: fentanyl and selective serotonin reuptake inhibitor interactions. AANA J. 2014;82:340-345.
Newman EJ, Grosset DG, Kennedy PG. The parkinsonism-hyperpyrexia syndrome. Neurocrit Care. 2009;10:136-140.
Richter T, Paluch Z, Alusik S. The non-antidepressant effects of citalopram: a clinician's perspective. Neuro Endocrinol Lett. 2014;35:7-12.

Chapter 44

Addiss DG, Davis JP, Meade BD, Burstyn DG, Meissner M, et al. A pertussis outbreak in a Wisconsin nursing home. J Infect Dis. 1991;164:704-710.
Al-Murieb A, Brown AM, Raulli A, George C, Gander C, et al. Evidence of pertussis clusters in three aged-care facilities in the former Macquarie Area Health Service, NSW. N S W Public Health Bull. 2008;19:157-160.
Castila J, Cia F, Zubicoa J, Reina G, Martinez-Artola V, Ezpeleta C. Influenza outbreaks in LTCF with high vaccination coverage in Navarre, Spain, 2011/12. Euro Surveil 2012;17:pii:20141.
Centers for Disease Control and Prevention. Prevention and control of tuberculosis in facilities providing long-term care to the elderly: recommendations of the Advisory Committee for Elimination of Tuberculosis. MMWR 1990;39(RR-10):7-20.
Edwards IR. Pharmacovigilance. Br J Clin Pharmacol. 2012;73:979-982.
High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello VJ, et al. Clinical Practice Guideline for the Evaluation of Fever and Infection in Older Adult Residents of Long-Term Care Facilities: 2008 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:149-171.
Hughes C, Smith M, Tunney M, Bradley MC. Infection control strategies for preventing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people. Cochrane Database Syst Rev 2011:CD006354.
Jin XW, Mossad SB. 2012–2013 Influenza update: hitting a rapidly moving target. Cleveland Clin J Medicine 2012;79:777-784.
Lawrance DT, Dobmeier SG, Bechtel LK, Holstege CT. Food poisoning. Emer Med Clin North Amer 2007;25:357-373.
Lee N, Chan PK, Hui DS, Rainer TH, Wong E, Choi KW et al. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. J Infect Dis 2009;200:492-500.
Lim CJ, Cheng AC, Kennon J, Spelman D, Hale D, et al. Prevalence of multidrug-resistant organisms and risk factors for carriage in long-term care facilities: a nested case-control study. J Antimicrob Chemother. 2014;69:1972-1980.
Louie JK, Lampiris H. Treating Influenza With Neuraminidase InhibitorsWhat Is the Evidence? JAMA Intern Med. 2015;175:1899-1900.
Lübbert C, Lippmann N, Busch T, Kaisers UX, Ducomble T, et al. Long-term carriage of Klebsiella pneumoniae carbapenemase-2-producing K pneumoniae after a large single-center outbreak in Germany. Am J Infect Control. 2014;42:376-380.
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed, 2009 Churchill Livingstone.
Murphy CR, Quan V, Kim D, Peterson E, Whealon M, Tan G, Evans K et al. LTCF characteristics associated with methicillin-resistant Staphylococcus aureus (MRSA) Burden and Transmission. BMC Infect Dis 2012;12:269.
Nyborg G, Sraand J, Brekke M. Inappropriate prescribing for the elderly-a modern epidemic? Eur J Clin Pharmacol 2012;68:1085-1094.
Rossolini GM. Extensively drug-resistant carbapenemase-producing Enterobacteriaceae: an emerging challenge for clinicians and healthcare systems. J Intern Med 2015; DOI: 10.1111/joim.12350.
Strausbaugh LJ, Sukumar SL, Joseph CL. Infectious disease outbreaks in LTCF: an unappreciated hazard for frail elderly persons. Clin Infect Dis 2003;36:870-806.
Trivedi TK, DeSalvo T, Lee L, Palumbo A, Moll M, Curns A et al. Hospitalizations and mortality associated with norovirus outbreaks in LTCF, 2009-2010. JAMA 2012;308:1668-1675.
Trivedi TK, DeSalvo T, Lee L, Palumbo A, Moll M, Cyrns A et al. Hospitalizations and Mortality Associated With Norovirus Outbreaks in LTCF, 2009-2010. JAMA. 2012;308:1-8.
Utsumi M, Makimoto K, Quoroshi N, Ashida N. Types of infectious outbreaks and their impact in elderly care facilities: a review of the literature. Age Aging 2010;39:299-305.

Chapter 45

High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello VJ, Richards C, Yoshikawa TT. Clinical Practice Guideline for the Evaluation of Fever and Infection in Older Adult Residents of Long-Term Care Facilities: 2008 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases 2009; 48:149–171.
Greisman LA, Mackowiak PA. Fever: beneficial and detrimental effects of antipyretics. Curr Opin Infect Dis 2002;15:241-245.
Hocker SE, Tian L, Li G, Steckelberg JM, Mandrekar JN, Rabinstein AA. Indicators of central fever in the neurologic intensive care unit. JAMA Neurol 2013;70;1499-1504. See comment in PubMed Commons below
Limpawattana P, Phungoen P, Mitsungnern T, Laosuangkoon W, Tansangworn N. Atypical presentations of older adults at the emergency department and associated factors. Arch Gerontol Geriatr. 2015. doi:10.1016/j.archger.2015.08.016.

Chapter 46

Buhr GT, Genao L, White HK. Urinary tract infections in long-term care residents. Clin Geriatr Med 2011;27:229-239.
Fraisse T, Lachaud L, Sotto A, Lavigne JP, Cariou G, et al. Recommendations of the Infectious Disease Committee of the French Association of Urology. Diagnosis, treatment and monitoring candiduria. Prog Urol. 2011;21:314-321.
Grabe M, Bartoletti R, Bjerklund-Johansen TE, et al. Guidelines on urological infections. European Association of Urology website. 2011.
Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52:e103.
Hecker M. Q: Is antibiotic treatment indicated in a patient with a positive urine culture but no symptoms? Clevel Clin J Med 2014;81:721-724.
High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello VJ, Richards C, Yoshikawa TT. Clinical Practice Guideline for the Evaluation of Fever and Infection in Older Adult Residents of Long-Term Care Facilities: 2008 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases 2009;48:149-171.
Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis 2010; 50: 625–663.
Hooton TM. Clinical practice. Uncomplicated urinary tract infection. N Engl J Med 2012; 366:1028-1037.
Juthani-Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical features to identify urinary tract infection in LTCF residents: a cohort study. J Am Geriatr Soc 2009;57:963-970.
Kwon JH, Fausone MK, Du H, Robicsek A, Peterson LR. Impact of laboratoryreported urine culture colony counts on the diagnosis and treatment of urinary tract infection for hospitalized patients. Am J Clin Pathol 2012;137:778-84.
Le Ray I, Dell’Aniello S, Bonnetain F, Azoulay L, Suissa S. Local estrogen therapy and risk of breast cancer recurrence among hormone-treated patients: a nested case-control study. Breast Cancer Res Treat. 2012;135:603-609.
Martelle AJ, Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA et al. Cranberries vs antibiotics to prevent urinary tract infections. A randomized double-blind noninferiority trial in premenopausal women. Arch Intern Med. 2011;171:1270-1278.
Robinson D, Cardozo L. Estrogens and the lower urinary tract. Neurourol Urodyn 2011; 30:754-757.
Shepherd AK, Pottinger PS. Management of urinary tract infections in the era of increasing antimicrobial resistance. Med Clin N Am 2013; 97: 737–757.
Wagenlehner FM, Umeh O, SteenbergenJ, Yuan G, Darouiche RO. Ceftolozane-tazobactam compared with levofl oxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial

(ASPECT-cUTI). Lancet 2015;385:1949–1956.
Wise GJ, Schlegel PN. Sterile pyuria. N Engl J Med 2015;372:1048-1054.

Chapter 47

Bhattacharya S. The facts about penicillin allergy: a review. J Adv Pharm Technol Res. 2010;1:11-17.
Bowker LK, Price JD, Smith SCV. Oxford Handbook of Geriatric Medicine, 2nd ed, Oxford Univ Press 2012, pp: 318-322.
Chalmers JD, Rother C, Salih W, Ewig S. Healthcare-associated pneumonia does not accurately identify potentially resistant pathogens: a systematic review and meta-analysis. Clin. Infect. Dis. 2014;58;330-339.
Chan TV. The patient with sore throat. Med Clin North Am 2010;94: 923-943.
de Jongh TO, Thiadens HA. Physical examination of the lungs in suspected

pneumonia. Ned Tijdschr Geneesk 2011;155:A2656.
El-Sohl AA, Pietrantoni C, Bhat A, Aquilina AT, Okada M, et al. Microbiology of severe aspiration pneumonia in institutionalized elderly. Am J Respir Crit Care Med 2003;167:1650-1654.
Falcone M, Blasi F, Menichetti F, Pea F, Violi F. Pneumonia in frail older patients: an up to date. Internal and Emergency Medicine 2012;7:415-424.
Falconer M, Corrao S, Licata G, Serra P, Venditti M. Clinical impact of broad-spectrum antibiotic therapy in patients with healthcare-associated pneumonia: a multicenter interventional study. Intern Emerg Med. 2012;7:523-531.
Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, et al. European position paper on rhinosinusitis and nasal polyps. Rhinology 2012:3:1-298.
Jenkins TC, Irwin A, Coombs L, DeAlleaume L, Ross SE, et al. Effects of clinical pathways for common outpatient infections on antibiotic prescribing. Amer J Med 2013;126:327-335.
Kosaku K, Ishii H, Kadota J. Healthcare-associated pneumonia and aspiration pneumonia. Aging Dis. 2015;6:27-37.
Kruse RL, Mehr DR. Boles KE, Lave JR, Binder EF, Madsen R, D'Agostino RB. Does hospitalization impact survival after lower respiratory infection in LTCF residents? Med Care 2004;42:860-870.
Lambotte O, Timsit JF, Garrouste-Orgeas M, Misset B, Benali A, Carlet J. The significance of distal bronchial samples with commensals in ventilator-associated pneumonia: colonizer or pathogen? Chest. 2002;122:1389–1399.
Shin YM, Oh Y-M, Shim TS, Lim C-M, Lee SD et al. Usefulness of quantitative endotracheal aspirate cultures in intensive care unit patients with suspected pneumonia. J Korean Med Sci. 2011;26:865–869.
Louie JK, Lampiris H. Treating influenza with neuraminidase inhibitors. What is the evidence? JAMA Intern Med. 2015;175:1899-1900.
Mortellaro C, Biancucci P, Picciolo G, Vercellino V. Eagle’s syndrome: importance of a corrected diagnosis and adequate surgical treatment. J Craniofac Surg 2002;13:755-758.
Mortensen EM, Halm EA, Pugh MJ, Copeland LA, Metersky M. Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia. JAMA. 2014;311:2199-2208.
Mylotte JR. Treatment of nursing home-aquired pneumonia: dogma vs. data. Am Family Physician 2009;79:945-47.
Myotte JM. LTCF-associated pneumonia. Clin Geriatr Med 2007;23:553-565.
Naughton BJ, Mylotte JM. Treatment guideline for LTCF-acquired pneumonia based on community practice. J Am Geriatr Soc 2000;48:82-88.
Quagliarello V, Ginter S, Han L, Van Ness P, Allore H, Tinetti M. Modifiable risk factors for LTCF-acquired pneumonia. Clin Infect Dis 2005;40:1-6.
Rossio R, Franchi C, Ardoino I, Djade CD, Tettamanti M, et al. Adherence to antibiotic treatment guidelines and outcomes in the hospitalized elderly with different types of pneumonia. Eur J Intern Med. 2015;26:330-337.
Ruiz-González A, Falguera M, Porcel JM, Martínez-Alonso M, Cabezas P, Geijo P, et al. C-reactive protein for discriminating treatment failure from slow responding pneumonia. Eur J Intern Med 2010;21:548-552.
Smith SR, Montgomery LG, Williams JW Jr. Treatment of mild to moderate sinusitis. Arch Intern Med 2012;172:510-513.
van der Maarel-Wierink CD1, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. Oral health care and aspiration pneumonia in frail older people: a systematic literature review. Gerodontology 2013;30:3-9.
van der Steen JT, Ooms ME, van der Wal G, Ribbe MW. Pneumonia: the demented patient's best friend? Discomfort after starting or withholding antibiotic treatment. J Am Geriatr Soc 2002;50:1681-1688.
Vergidis P, Hamer DH, Meydani SN, Dallal GE, Barlam TF. Patterns of antimicrobial use for respiratory tract infections among older residents of long-term care facilities. J Am Geriatr Soc. 2011;59:1093-1098.
Wiersinga WJ, Bonten MJ, Boersma WG et al. SWAB/NVALT (Dutch Working Party on Antibiotic Policy and Dutch Association of Chest Physicians) guidelines on the management of community-acquired pneumonia in adults. Neth J Med 2012; 70:90-101.

Chapter 48

Falagas ME, Vergidis PI. Narrative review: diseases that masquerade as infectious cellulitis. Ann Intern Med 2005;142:47-55.
Jeng A, Behesti M, Li J, Nathan R. The Role of [beta]-hemolytic streptococci in causing diffuse, nonculturable cellulitis: a prospective investigation. Medicine (Baltimore) 2010;89:217-226.
Jones R, Horn HM. Identifying the causes of contact dermatitis. Practioner 2014;258:27-31.
Koster JB, Kullberg BJ, van der Meer JWM. Recurrent erysipelas despite antibiotic prophylaxis: an analysis from case studies. Netherl J Med 2007;65:89-93.
Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011; 52:e18-55.
Miller LG, Daum RS, Creech CB, Young D, Downing MD, et al. Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections. N Engl J Med 2015; 372:1093-1103.
Pallin DJ, Binder WD, Allen MB, Lederman M, Parmar S, et al. Clinical trial: comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: a randomized controlled trial. Clin Infect Dis 2013;56:1754-1762.
Pertel PE, Eisenstein BI, Link AS, Donfrid B, Biermann EJA, Bernardo P, et al. The efficacy and safety of daptomycin vs. vancomycin for the treatament of cellulitis and erysipelas. Int J Clin Pract 2009;63:368-375.
Strazzula L, Cotliar J, Fox LP, Hughey L, Shinkai K et al. Inpatient dermatology consultation aids diagnosis of cellulitis among hospitalized patients: A multi-institutional analysis. J Am Acad Dermatol 2015;73:70-75.
Thomas KS, Crook AM, Nunn AJ, Foster KA, Mason JM, Chalmers JR et al. Penicillin to prevent recurrent leg cellulitis. N Engl J Med 2013;368:1695-1703.

Chapter 49

Boucher H, Miller LG, Razonable RR. Serious infections caused by methicillin-resistant staphylococcus aureus. Clin Infect Dis. 2010;51 (Suppl 2):S183-S197.
Chang AY, Carlos CA, Schuster M, Xu X, Rosenbach M. Nonpseudomonal ecthyma gangrenosum associated with methicillin-resistant staphylococcus aureus infection: a case report and review of the literature. Cutis 2012;90:67-69.
Marwick C, Santiago VH, McCowan C, Broomhall J, Davey P. Community acquired infections in older patients admitted to hospital from care homes versus the community: cohort study of microbiology and outcomes. BMC Geriatr. 2013;13:12.
Miller LG, Daum RS, Creech CB, Young D, Downing MD et al. Clindamycin versus trimethoprim–sulfamethoxazole for uncomplicated skin infections. N Engl J Med 2015; 372:1093-1110.
Moran GJ, Abrahamian FM, Lovecchio F, Talan DA. Acute bacterial skin infections: developments since the 2005 Infectious Diseases Society of America (IDSA) Guidelines. J Emerg Med. 2013;44:e397-412.
Ray GT, Suaya JA, Baxter R. Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. Population: a retrospective population-based study. BMC Infect Dis. 2013 13:252.
Wessels MR. Choosing an antibiotic for skin infections. N Engl J Med 2015;372:1164-1165.

Chapter 50

Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007;132:237-251.
Johnson RW. Zoster-associated pain: what is known, who is at risk and how can it be managed? Herpes. 2007;14 (Suppl 2):30-34. Cohen JI. Herpes zoster. N Engl J Med 2013;369:255-263.
Sampathkumar P, Drage LA, Martin DP. Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clin Proc 2009;84:274-280.

Chapter 51

American Diabetes Association. Standards of medical care in diabetes-2013. Diabetes Care. 2013;36 Suppl 1:S11.
Boulton AJM. The pathway to foot ulceration in diabetes. Med Clin N Am 2013;97:775-790.
Braun LR, Fisk WA, Lev-Tov H, Kirsner RS, Isseroff RR. Diabetic foot ulcer: an evidence-based treatment update. Am J Clin Dermatol. 2014;15:267-281. See comment in PubMed Commons below
Capobianco CM, Stapleton JJ. Diabetic foot infections: a team-oriented review of medical and surgical management. Diabet Foot Ankle. 2010;1:10.
Hyperbaric oxygen for the treatment of diabetic foot ulcers: a systematic review. Eur J Vasc Endovasc Surg. 2014;47:647-655.
Ishikawa SN. Diabetic foot. Campbell's Operative Orthopaedics, 2013;85: 4057-4077.e2 M, Izzo V, Vainieri E, Giurato L, Ruotolo V, et al. Management of negative pressure wound therapy in the treatment of diabetic foot ulcers. World J Orthop. 2015;6:387-393.
Larsen R, Jensen T, Karlsmark T, Holstein PE. Incidence of bullosis diabeticorum - a controversial cause of chronic foot ulceration. Int Wound J. 2008;5:592-596.
Lazaro-Martinez JL, Aragon-Sanchez J, Garcia-Morales E. Antibiotics versus conservative surgery for treating diabetic foot osteomyelitis: a randomized comparative trial. Diabetes Care 2014;37:789e95.
Lipsky BA, Berendt AR, Cornia PB, Pile JC, Peters EJ, Armstrong DG, et al. Infectious Diseases Society of America. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54:e132.
Lipsky BA. Treating diabetic foot osteomyelitis primarily with surgery or antibiotics: have we answered the question? Diabetes Care 2014;37: 593e5.
Peters EJ, Lipsky BA, Aragón-Sánchez J, Boyko EJ, Diggle M et al. Interventions in the management of infection in the foot in diabetes: a systematic review. Diabetes Metab Res Rev. 2015. doi: 10.1002/dmrr.2706.
Peters EJD, Lipsky BA. Diagnosis and management of infection in the diabetic foot. Med Clin N Am 2013;97:911–946.
Stoekenbroek RM, Santema TB, Legemate DA, Ubbink DT, van den Brink A, et al.

Chapter 52

Allen SJ, Wareham K, Wang D, Bradley C, HutchingsH et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium diffi cile diarrhoea in older inpatients (PLACIDE): a randomized, double-blind, placebo-controlled, multicentre trial. Lancet 2013; 382: 1249–1257.
Austin M, Mellow M, Tierney WM. Fecal microbiota transplantation in the treatment of Clostridium difficile infections. Amer J Med 2014;127:479–483.
Eyre DW, Griffiths D, Vaughan A, Golubchik T, Acharya M et al. Asymptomatic clostridium difficile colonisation and onward transmission. PLoS One. 2013;8:e78445.
Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S et al. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 2007;335:80.
High KP, Bradley SF, Gravenstein S, Mehr DM, Quagliarello VJ, Richards C. Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009; 48:149-171.
Khanna S, Pardi DS. Clostridium difficile infection: new insights into management. Mayo Clin Proc 2012;87:1106-1117.
Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med 2015;372:1539-1548.
Monaghan T, Boswell T, Mahida YR. Recent advances in clostridium difficile-associated disease. Postgrad Med J 2009;85:152-162.
Pham VP, Luce AM, Ruppelt SC, Wei W, Aitken SL, et al. Age-stratified treatment response rates in hospitalized patients with Clostridium difficile infection treated with metronidazole. Antimicrob Agents Chemother. 2015. pii: AAC.00816-15. [Epub ahead of print].
Simor AE, Bradley SF, Strausbaugh LJ et al. Clostridium difficile in long-termcare facilities for the elderly. Infect Control Hosp Epidemiol 2002;23:696-703.
Simor AE. Diagnosis, management, and prevention of Clostridium difficile infection in long-term care facilities: A review. J Am Geriatr Soc 2010;58:1556-1564.
Thielman NM, Guerrant RL. Acute infectious diarrhea. N Engl J Med 2004; 350:38-47.
White KE, Hedberg CW, Edmonson LM, Jones DB, Osterholm MT, MacDonald KL. An outbreak of giardiasis in a LTCF with evidence for multiple modes of transmission. J Infect Dis. 1989;160:298-304.

Chapter 53

Arinzon Z, Peisakh A, Schrire S, Berner YN. Prevalence of hypomagnesemia (HM) in a geriatric long-term care (LTC) setting. Arch Gerontol Geriatr. 2010;51:36-40.
Arumugam GP, Sundravel S, Shanthi P, Sachdanandam P. Tamoxifen flare hypercalcemia: an additional support for gallium nitrate usage.

J Bone Miner Metab. 2006;24:243-247.
Block GA, Wheeler DC, Persky MS, et al. Effects of phosphate binders in moderate CKD. J Am Soc Nephrol 2012; 23:1407-1415.

Chassagne P, Druesne L, Capet C, Menard JF, Bercoff E. Clinical presentation of hypernatremia in elderly patients: a case control study.

J Am Geriatr Soc. 2006;54:1225-1230.
Felker MG, Lee KL, Bull DA, Redfield MM, Stevenson LW et al. for the NHLBI Heart Failure Clinical Research Network. Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med 2011; 364:797-805.
Fenske W, Störk S, Koschker A-C, Blechschmidt A, Lorenz D et al. Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrino Metab 2008; 93:2991-2997.
Groeneveld JHM, Sijpkens YWJ, Lin SH, Davids MR, Halperin ML. An approach to the patient with severe hypokalaemia: the potassium quiz. QJM 2005; 98; 305-316.
Inouye SI. Delirium in older persons. N Engl J Med 2006;354:1157-1165.
Khanna A, White WB. The management of hyperkalemia in patients with cardiovascular disease. Amer J Med 2009;122:215-221.
Luk CP, Parsons R, Lee YP, Hughes JD. Proton pump inhibitor-associated hypomagnesemia: what do FDA data tell us? Ann Pharmacother. 2013;47:773-780.
Martin KJ, González EA, Slatopolsky E. Clinical consequences and management of hypomagnesemia. J Am Soc Nephrol. 2009; 20:2291-2295.
Moe SM. Disorders involving calcium, phosphorus, and magnesium. Prim Care Clin Office Pract. 2008;35:215–237.
Morris GS, Landry CL, Grubbs EG, Jimenez C, Busaidy NL, Perrier ND. Greater than age-predicted functional deficits in older patients with primary hyperparathyroidism. Endocr Pract. 2012;18:450-455.
Mugeet Adrian M, Bhutta U, Iobal T, AbdulMuieeb S, Hargsim L et al. Severe hypocalcemia due to denosumab in metastatic prostate cancer. Case Rep Nephrol. 2014:565393.
National Kidney Foundation. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003;42:S1-201.
Nguyen MK, Kurtz I. Correction of hypervolaemic hypernatraemia by inducing negative Na+ and K+ balance in excess of negative water balance: a new quantitative approach. Nephrol Dial Transplant. 2008;23:2223-2227.
Rastegar A, Soleimani M, Rastergar A. Hypokalaemia and hyperkalaemia. Postgrad Med J 2001; 77:759-764.
Smogorzewski MJ. Robert RK, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Brenner and Rector's the Kidney, Saunders, 9th Ed, 2012, pp 689-725.
Sterns RH. Disorders of plasma sodium - causes, consequences, and correction. N Engl J Med 2015; 372:55-65.
Urso C, Brucculeri S, Caimi G. Acid-base and electrolyte abnormalities in heart failure: pathophysiology and implications. Heart Fail Rev. 2015;20:493-503.
Wald R, Jaber BL, Price LL, Upadhyay A, Madias NE. Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med. 2010;170:294-302.

Chapter 54

Berna C, Kulich RJ, Rathmell JP. Tapering Long-term opioid therapy in chronic noncancer pain: evidence and recommendations for everyday practice. Mayo Clin Proc. 2015;90:828-842.

Bula P, Lein T, Straßberger C, Bonnaire F. Balloon kyphoplasty in the treatment of osteoporotic vertebral fractures: indications - treatment strategy - complications. Z Orthop Unfall. 2010;148:646-656.
Cohen SP. Epidemiology, diagnosis and treatment of neck pain. Mayo Clin Proc 2015;90:284-299.
Devereaux M. Low back pain. Med Clin North Amer 2009; 93:477-501.
Friedly JL, Comstock BA, Turner JA, Heagerty PJ, Deyo RA et al. A randomized trial of epidural glucocorticoid injections for spinal stenosis. N Engl J Med 2014;371:11-21.

Furlan AD, Imamura M, Dryden T, Irvin E. Massage for low back pain: an updated systematic review within the framework of the Cochrane Back Review Group. Spine (Phila Pa 1976) 2009; 34:1669.
Lamb SE, Hansen Z, Lall R, Lall R, Castelnuovo E, Withers EJ et al

. Group cognitive behavioural treatment for low-back pain in primary care: a randomised controlled trial and cost-effectiveness analysis. Lancet 2010; 375:916-923.
Lamy O, Uebelhart B, Aubry-Rozier B. Risks and benefits of percutaneous vertebroplasty or kyphoplasty in the management of osteoporotic vertebral fractures. Osteoporos Int. 2013;25:807-819.
Last RA, Hulbert K. Chronic low back pain: evaluation and management. Amer Fam Physician 2009;79:1067-1074.
Ropper AH, Zafonte RD. Sciatica. N Engl J Med 2015;372:1240-1248.
Tabesh H, Tabesh A, Fakharian E, Fazel M, Abrishamkar S. The effect of age on result of straight leg raising test in patients suffering lumbar disc herniation and sciatica. J Res Med Sci. 2015;20:150-153.
Vickers AJ, Cronin AM, Maschino AC, Lewith G, et al. for the Acupuncture Trialists' Collaboration. Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med. 2012;172:1-10.

Chapter 55

Field M. Acute Monoarthritis. In: Firestein: Kelley's Textbook of Rheumatology, 9th ed, 2012, Saunders.
Khannaa PP, FitzGerald J. Evolution of management of gout: a comparison of recent guidelines. Curr Opin Rheumatol 2015, 27:139-146.
Mandell BF, Edwards LN, Sundy JS, Simkin PA, Pile JC. Preventing and treating acute gout attacks across the clinical spectrum: A roundtable discussion. Cleveland Clin J Med 2010; 77(Suppl 2):S2-S25.
Slobodnick A, Shah B, Pillinger MH, Krasnokutsky S. Colchicine: old and new. Amer J Med 2015;128:461-470.

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