Polyhydroxyalkanoates (PHAs): Biosynthesis, Industrial Production and Applications in Medicine

$215.00

Lin-Ping Wu, PhD (Editor)
Centre for Pharmaceutical Nanotechnology and Nanotoxicology, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

Series: Nanotechnology Science and Technology
BISAC: TEC027000

In recent years, polyhydroxyalkanoates (PHAs), the only family of biopolyesters completely synthesized by biological means, received increasing attention because of their attractive properties and wide applications. PHAs and their related academic and industrial chains have affected our daily lives in fermentation, materials, feeds, energy as well as in the medical fields. It is very important to understand all aspects related to the PHAs their processes in this valuable field. This book presents a general overview of PHAs from the biosynthesis, fermentation, industrial production, extraction, purification and application.

This book consists of four sections including 21 original chapters, which together provide a comprehensive introduction to the subject, and the detail information for the biosynthesis, industrial production, and medical application of PHAs. This book is written to be accessible to a wide readership, especially for beginners who have just started PHA related research. In a word, this book summarizes the literature data and recent research results on PHAs with a state-of-the-art description of the present, challenge and future of PHAs. (Imprint: Nova)

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Table of Contents

Preface

Section 1: General Introduction

Chapter 1 – Overview of Polyhydroxyalkanoates (PHAs) (pp. 3-6)
Lin-Ping Wu and Danyang Wang (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark)

Chapter 2 – Commercial Polyhydroxyalkanoates (PHAs) (pp. 7-20)
Chong-bo Chen and Lin-Ping Wu (Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China and others)

Chapter 3 – Unusual Polyhydroxyalkanoates (PHAs) (pp. 21-36)
Chong-bo Chen and Lin-Ping Wu (Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China and others)

Chapter 4 – Detection, Quantification and Property Analysis of Polyhydroxyalkanoates (pp. 37-50)
Bin Li and Lin-Ping Wu (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark)

Chapter 5 – The Applications of Polyhydroxyalkanoates (PHAs) (pp. 51-66)
Shaoting Cheng and Lin-Ping Wu (Stem Cell Institute for Medical Research, Fujian Medical University, Fujian Province, China and others)

Chapter 6 – Challenge and Future Outlook (pp. 67-72)
Lin-Ping Wu and Danyang Wang (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark)

Section 2: Biosynthesis

Chapter 7 – Biosynthesis Pathways of PHA (pp. 75-82)
Adrian Douglas Allen, Folahan O. Ayorinde and Broderick E. Eribo (Howard University, DC, US)

Chapter 8 – The Role of Genetic Engineering in PHA Biosynthesis (pp. 83-88)
Adrian Douglas Allen, Folahan O. Ayorinde and Broderick E. Eribo (Howard University, DC, US)

Chapter 9 – Substrates for PHA Biosynthesi (pp. 89-98)
Adrian Douglas Allen, Folahan O. Ayorinde and Broderick E. Eribo (Howard University, DC, US)

Chapter 10 – Biosynthesis of PHA in Wildtype Bacteria (pp. 99-106)
Adrian Douglas Allen, Folahan O. Ayorinde and Broderick E. Eribo (Howard University, DC, US)

Chapter 11 – Biosynthesis of PHA in Higher Organisms (pp. 107-112)
Adrian Douglas Allen, Folahan O. Ayorinde and Broderick E. Eribo (Howard University, DC, US)

Chapter 12 – Biosynthesis of Short-Chain-Length PHA by Halophiles (pp. 113-130)
Jing Han (Institute of Microbiology, Chinese Academy of Sciences, Beijing, China)

Section 3: Industrial Production

Chapter 13 – The Industrial Production of PHA (pp. 133-140)
Rong-Cong Luo, Yun-Long Wu and Mohamed EI-Newehy (Department of Bioengineering, National University of Singapore, Singapore and others)

Chapter 14 – Extraction and Purification of Polyhydroxyalkanoates (pp. 141-152)
Rong-Cong Luo, Yun-Long Wu and Mohamed EI-Newehy (Department of Bioengineering, National University of Singapore, Singapore and others)

Chapter 15 – Industrial Production of PHA: Recent Breakthroughs and Remaining Bottlenecks (pp. 153-168)
Nathalie Berezina and Silvia Maria Martelli (Materia Nova, Ghislenghien, Belgium and others)

Section 4: Applications in Medicine

Chapter 16 – Biodegradation of PHA in Nature (pp. 171-180)
Adrian Douglas Allen, Folahan O. Ayorinde and Broderick E. Eribo (Howard University, DC, US)

Chapter 17 – Chemical Modification of PHAs (pp. 181-218)
Zibiao Li and Lin-Ping Wu (Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research, Research Link, Singapore and others)

Chapter 18 – Polyhydroxyalkanoates and Their Potential in Controlled-Release Drug Delivery Systems – Biomedical Applications and Factors Affecting the Drug Release (pp. 219-236)
Thiago Caon, Nathalie Berezina, Carol Sze Ki Lin, Farayde Matta Fakhouri and Silvia Maria Martelli (Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Brazil and others)

Chapter 19 – PHA-Based Materials at Interfaces Control Biomimetic Crystallization of Bone Minerals (pp. 237-256)
Katarzyna Kita-Tokarczyk, Agnieszka Jagoda and Manfred Zinn (Department of Chemistry, University of Basel, Basel, and University of Applied Science Western Switzerland (HES SO Valais), Institute of Life Technologies, Sion, Switzerland)

Chapter 20 – The Cytotoxicity of Polyhydroxyalkanoates As Biomedical Materials (pp. 257-272)
Xiaoyong Guo, Danyang Wang and Lin-Ping Wu (Translational Medicine Research & Development Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Shenzhen, China and others)

Chapter 21 – Biomedical Studies of PHAs Produced in the Institute of Biophysics SB RAS and Siberian Federal University (Krasnoyarsk, Russia) (pp. 273-330)
Tatiana Volova and Ekaterina Shishatskaya (Institute of Biophysics SB RAS, and Siberian Federal University, Krasnoyarsk, Russia)

Index

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