PM2.5: Role of Oxidative Stress in Health Effects and Prevention Strategy

Ying-Ji Li (Editor)
Department of Hygiene and Public Health, Nippon Medical School, Nezu, Bunkyo-ku, Tokyo, Japan
Masakazu Umezawa (Editor)
Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan
Hajime Takizawa (Editor)
Department of Respiratory Medicine, Kyorin University Hospital, Tokyo, Japan
Ken Takeda (Editor)
Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan
Tomoyuki Kawada (Editor)
Department of Hygiene and Public Health, Nippon Medical School, Nezu, Bunkyo-ku, Tokyo, Japan

Series: Public Health in the 21st Century
BISAC: MED078000

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Air pollution has been associated with significant adverse health effects, including increased morbidity and mortality. The global increase in the prevalence of diseases that are associated with exposure to air pollution is of great concern. In particular, severe PM2.5 pollution occurs in Asian countries due to increasing emissions of air pollutants caused by the countries’ rapid economic growth. A number of studies have been performed to clarify the association between PM2.5 and disorders such as asthma, ischemic cardiovascular diseases, arteriosclerosis, cancer, and neurological disorders. It is important to protect populations that are susceptible to such pollution. While the characterization and monitoring of pollutant components currently dictates pollution control policies, it will be necessary to identify susceptible populations in order to adequately target prevention strategies for the health effects of air pollution. This book offers a comprehensive review of the recent advances in our understanding of the health effects of PM2.5, the role of oxidative stress in these effects, the contribution of ultrafine fractions of PM2.5 to the health effects, and discusses prevention strategies for these health effects. It also suggests further risk assessment, risk management, and novel policies for PM2.5 pollution, required to protect public health. (Imprint: Nova)

Preface

Section 1: Worldwide Air Quality Guidelines, Standards, and Recent Trends in East Asia

National Ambient Air Quality Standards for Fine Particles (PM2.5) in Japan
(Kenichi Azuma and Iwao Uchiyama, Department of Environmental Medicine and Behavioral Science, Kinki University Faculty of Medicine, Japan, and other)

Atmospheric Behaviors of Polycyclic Aromatic Hydrocarbons as a Marker of PM2.5 in East Asia
(Kazuichi Hayakawa, Ning Tang, Takayuki Kameda and Akira Toriba1, Faculty of Pharmaceutical Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan, and others)

The Study on Air PM2.5 Pollution Health Effects – Recent Trends in China Current Conditions
(Xiaochuan Pan, Peking University School of Public Health, China)

PM2.5 Pollution in East Asia: Current Status and Strategy Towards Improving Air Quality
(Toshimasa Ohara, National Institute for Environmental Studies, Japan)

Section 2: The Role of Nuclear Factor-like 2 (Nrf2) in Diseases Progression and Biological Effects Caused by Major Component of PM2.5-diesel Exhaust Particles-induced Oxidative Stress

A Pivotal Role of Nrf2 in Airway Inflammatory Responses Induced by Diesel Exhaust in Asthma: Mechanisms and Their Application to Clinical Interventions
(Hiroo Wada, Toshiya Inui, Keitaro Nakamoto, Mitsuru Sada, Masuo Nakamura, and Hajime Takizawa, Respiratory Medicine, Kyorin University School of Medicine, and other)

Effects of DEP Inhalation on Development of Infectious Diseases
(Tadashi Kohyama, Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, Japan)

DNA Adduct Formation by Diesel Exhaust and its Relevance to Carcinogenesis
(Masafumi Horie, Department of Respiratory Medicine, The University of Tokyo Hospital, Japan)

Effects of Diesel Exhaust Particles on the Cardiovascular System: Experimental and Clinical Findings
(Yasuhiro Yamauchi and Hajime Takizawa, Department of Respiratory Medicine, The University of Tokyo, Japan, and other)

Neurotoxicity of DEPs
(Satoshi Noguchi, Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Japan)

Effects of Air Pollution on Diabetes: Epidemiological and Pathophysiological Insights
(Katsuhito Kato, Environmental Medicine, Graduate School of Medicine, Nippon Medical School, Japan)

Adverse Fetal Effects of Diesel Exhaust –Induced Oxidative Stress
(Yu Mikami, Department of Respiratory Medicine, Graduate school of Medicine, The University of Tokyo, Japan)

Section 3: The Biological Effects/toxicity of Nanoparticles, an Ultrafine Fraction of PM2.5 in the Atmosphere, and Their Potential Relationship with Diseases Progression

Atmospheric Nanoparticles and their Potential Health Effects
(Yuji Fujitani, Akiko Furuyama and Seishiro Hirano, Center for Environmental Risk Research, National Institute for Environmental Studies, Japan)

Findings Regarding the Hazard Assessment of Nanoparticles and their Effects on the Next Generation
(Masakazu Umezawa, Atsuto Onoda and Ken Takeda, The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, Japan, and other)
Free Download Available

Silica Nanoparticles Induce Production of Inflammatory Cytokines Through ATP Signaling via Purine Receptors
(Shuji Kojima, Mitsutoshi Tsukimoto and Ken Takeda, Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences,
Tokyo University of Science, Japan, and other)

Section 4: Prevention Strategies and Prospects for Populations Susceptible to Particulate Pollution

The Potential Protective Effect of Antioxidants on Nanoparticle Toxicity
(Atsuto Onoda, Masakazu Umezawa and Ken Takeda, Department of Hygienic Chemistry, Graduate School of Pharmaceutical Sciences, Tokyo University of Science, Japan)
Free Download Available

Antioxidant Interventions as Potential Protective Strategies for Populations Susceptible to Diesel Exhaust Particles
(Ying-JI Li, Hajime Takizawa, Arata Azuma, and Tomoyuki Kawada, Department of Hygiene and Public Health, Nippon Medical School, Japan, and others)
Free Download Available

Fine and Ultrafine Particle Risk Management: Problems to be Solved
(Masakazu Umezawa and Miho Namba, The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, Japan, and other)
Free Download Available

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