Plasminogen Activator: Genetic Factors, Functions and Clinical Applications


Jeremiah M. Rutherford (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: MED009000

The Plasminogen Activator System (PAS) is a multifunctional protease system known to possess mitogenic, chemotactic, adhesive and migratory properties. Consequently, it plays an essential role in the process of tumor cell growth and metastasis. Tissue plasminogen activator (tPA) is a member of the serine protease family that plays a pivotal role in the homeostasis of blood coagulation/fibrinolysis and matrix regulation. This book discusses the use of PAS in cancer treatment; its role in chronic kidney disease; the genetic factors, functions, and clinical applications; obesity in adolescents; and the mutual interactions and potential combinatory implications in oncotherapies. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Chapter 1 – Targeting Plasminogen Activator System in Cancer Treatment (pp. 1-32)
Ezio Fasoli and Vibha Bansal (Department of Chemistry, University of Puerto Rico at Humacao, Humacao, PR, USA, and others)

Chapter 2 – Interplay of Plasminogen Activator with the Plasma Kallikrein-Kinin System (pp. 33-52)
Dhaval Kolte, Jaya Mallela and Zia Shariat-Madar (Department of Medicine, New York Medical College, Valhalla, NY, USA, and others)

Chapter 3 – Tissue Plasminogen Activator and Chronic Kidney Disease: More than a Simple Protease (pp. 53-68)
Ling Lin and Kebin Hu (Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania, USA)

Chapter 4 – Plasminogen Activator Inhibitor-1 in Pediatrics: Genetic Factors, Functions and Clinical Applications (pp. 69-96)
Ramón Cañete, Miguel Valle, Rosario Martos, María Dolores Cañete and Eva L. van Donkeelar (Pediatric Endocrinology Unit. Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC Maimónides Institute for Biomedical Research in Cordova), Cordova, Spain, and others)

Chapter 5 – Plasminogen Activator Inhibitor and Obesity in Adolescents (pp. 97-138)
Deborah Cristina Landi Masquio, Raquel Munhoz da Silveira Campos, Bárbara Dal Molin Netto and Ana R. Dâmaso (Post-Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo-SP, Brasil, and others)

Chapter 6 – Transforming Growth Factor-Beta Regulation of Urokinase Type Plasminogen System: Mutual Interactions and Potential Combinatory Implications in Oncotherapies (pp. 139-208)
Juan F. Santibanez and Jelena Krstic (Laboratory for Experimental Hematology. Institute for Medical Research (IMI). University of Belgrade, Dr. Subotića, Belgrade, Serbia)



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