Pitfalls of the Conventional in Vitro Suppressive Assays for Regulatory T Cells and an Alternative Quantitative Assay

Hyung-Ran Kim, Bo-Gie Yang, Yun-Jae Jung, Myoung Ho Jang, Seikwan Oh and Ju-Young Seoh
Ewha Womans University Medical School, Seoul, Korea, and others

Series: Cell Biology Research Progress, Immunology and Immune System Disorders
BISAC: SCI017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Regulatory T cells (Tregs) are important in the maintenance of immune homeostasis in vivo. Although, Tregs were initially identified for their critical role to prevent autoimmune diseases, they are also important in the regulation of almost all kinds of immune responses, including infection, graft rejection, immune reactions to fetus or tumor cells as well as hypersensitivity reactions. Therefore, how the functional activity of Tregs is regulated is pivotal to the immune homeostasis in vivo, and an accurate assay is essential to study the functional activity of Tregs. (Imprint: Nova)

1. In vitro proliferation of Treg is dependent on exogenous IL-2 or the responding cells.

2. Feedback loop of immune regulation by Tregs

3. Tregs proliferate well in vitro as well as in vivo.

4. Distinct mode of suppression according to the strength of signal

5. Antigen presenting cells (APCs) and APC-free system

6. Pitfalls of in vitro suppressive assay

7. An alternative quantitative suppressive assay

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