Pioneer of the Homocysteine Theory

Kilmer Serjus McCully
Network Consolidated Laboratories, VA New England Healthcare System; Associate Clinical Professor of Pathology, Harvard Medical School, VA Medical Center, West Roxbury, MA

Series: Cardiology Research and Clinical Developments, Cancer Etiology, Diagnosis and Treatments
BISAC: MED010000

This personal scientific memoir describes how a chance observation concerning artery disease in children with rare inherited abnormalities of metabolism, often called experiments of Nature, led to the discovery of a new theory of heart disease, cancer and diseases of aging. As explained in subsequent chapters, this new theory places the amino acid homocysteine at the heart of altered metabolism of diseases of aging. Not only does this theory illuminate and explain the origin of these diseases, development of this theory logically leads to a novel and revolutionary metabolic and nutritional program for disease prevention and treatment, potentially benefiting individuals and populations. (Imprint: Nova Biomedical )


Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Table of Contents

Chapter 1. Introduction: A Chance Discovery Concerning the Cause of Heart Disease

Chapter 2. Origins: From Pioneer Ancestry to Medical Science at Harvard

Chapter 3. Discovery: The Amino Acid Homocysteine is Implicated in Heart Disease, Cancer and Aging

Chapter 4. Exploration: Homocysteine Research and the Molecular Basis of Disease

Chapter 5. Rejection: The Medical Establishment Rejects Homocysteine Research

Chapter 6. Exile: After Black-Balling, a New Opportunity Opens in Medical Science

Chapter 7. Redemption: Worldwide Homocysteine Research Confirms Theories

Chapter 8. Development of Homocysteine Research

Chapter 9. The Heart Revolution

Chapter 10. Homocysteine and Cancer

Chapter 11. Stem Cells, Paprika and Apricots: Effect on the Cancer Industry

Chapter 12. Homocysteine and Aging

Chapter 13. Conclusions: Legacy of a New Understanding of Disease


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