Photonic Hemostasis – Physiology of Light Signals in the Neutrophil

Thomas Stief
Specialist for Laboratory Medicine, Institute of Laboratory Medicine and Pathobiochemistry, University Hospital, Baldingerstr, Marburg, Germany

Series: Cell Biology Research Progress
BISAC: SCI008000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Neutrophil granulocytes are the primary defense cells of blood against bacteria, fungi, parasites, or thrombi. Their main weapons and signals are reactive oxygen species (ROS) that release photons. The activation of the assembly of their NADPH-oxidase, the few specific triggers and many specific or unspecific primers are of great physiological and pathophysiological importance in inflammation and in hemostasis. The neutrophils generate different types of photons and they can “see” them.

The 300-400 nm photons are the main signals and the photons of lowest wave length seem to especially alert them in emergency. The present book presents research on the regulation of the neutrophil´s ROS generation by different photons, by singlet oxygen (the excited “pro-drug” of photons), by important proteins, or by modulators of the eicosanoid metabolism that should not favor the generation of systemically circulating micro-thrombi. (Imprint: Nova Biomedical )

Preface

Chapter 1. Light Quants of Low Wave Length (405 nm Violet Photons) Prime Blood Neutrophils for ROS Generation

Chapter 2. Blood Neutrophils see UV Light: 340 nm Ultraviolet A Stimulates Blood ROS Generation Nearly Half as Strong as 405 nm Violet Photons

Chapter 3. Blood Neutrophils Alert Each Other by Photons

Chapter 4. Singlet Oxygen (1O2*) Primes Blood Neutrophils to Generate ROS

Chapter 5. Singlet Oxygen – Oxidized Human Albumin Stimulates Blood ROS Generation

Chapter 6. Human IgG can Modulate Blood ROS Generation

Chapter 7. Naproxen is only a Mild Inhibitor of Neutrophils

Chapter 8. Therapeutic Human Antithrombin-3 Inhibits Blood ROS Generation

Chapter 9. Thrombin Generation by Naproxen

Index

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