Pharmacological Treatment of Ocular Inflammatory Diseases


Authors: Tais Gratieri, Renata F. V. Lopez, Elisabet Gonzalez-Mira, Maria A. Egea, Marisa L. Garcia and Eliana B. Souto (Universidade de São Paulo, São Paulo, Brazil, and others)

Series: Eye and Vision Research Developments

Novel strategies for ocular anti-inflammatory therapies are extensively being investigated to increase drug bioavailability and decrease adverse side effects of common treatments. Colloidal carriers based on lipid materials are becoming a suitable alternative due to several advantages, including solubilization of hydrophobic/lipophilic anti-inflammatory drugs followed by bioavailability enhancement, modification of pharmacokinetic parameters, and protection of sensitive drugs from physical, chemical or biological degradation. This book presents and discusses data on the improvements being made in regards to novel drug delivery systems.



Table of Contents:
1. Introduction

2. Mechanism of Inflammation

2.1. Corticosteroids

2.2. Non-Steroidal Anti-Inflamatory Drugs (NSAIDs)

3. Novel Lipid-Based Drug Delivery Systems for Ocular Inflammatory Diseases

3.1. Microemulsions

3.2. Nanoemulsions

3.3. Liposomes

3.4. Lipid Nanoparticles (SLN and NLC)

4. Conclusions and Future Trends


Additional information