Peripheral Nerve Injury and Pain: Epidemiology, Mechanisms, Rehabilitation and Treatment Guidelines

Albert Leung, M.D. (Editor)
The University of California, San Diego, School of Medicine, Center for Pain Medicine

Series: Neuroscience Research Progress
BISAC: MED057000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Post-traumatic peripheral neuropathic pain (PTP-NP) is a common debilitating neuropathic pain condition. After certain types of physical trauma or surgical procedures, the prevalence of PTP-NP can exceed 60%. Clinically, a significant degree of pain with altered sensitivity at the area of the trauma or within the distribution of the affected peripheral nerve(s) has been the hallmark of PTP-NP. In this chapter, the authors review the epidemiology, economic impact, and major causes of PTP-NP. Detailed neuronal, cellular and molecular mechanisms leading to the development of PTP-NP are discussed. In addition, the authors explore the current available pharmacological and non-pharmacological treatment options, as well as the direction for future research and treatment development. While you may find the content of some chapters overlapping with others, they collectively serve as a comprehensive resource to reinforce your understanding in this common chronic pain condition and enhance your ability in managing patients living with this debilitating condition.

The editor thanks all contributing authors for their work and Ms. Mellissa Medeiros for her editing effort.

He dedicates this book to his late mother, Dr. Haidy J. Fung (1939-2018), for inspiring his interest in medicine.


Chapter 1. The Impact of Peripheral Nerve Injury on Pain and Quality of Life
(Jonathan Chu, MD, Michael Vaninetti, MD and Albert Leung, MD)

Chapter 2. From Peripheral Nerve Injury to Chronic Pain States
(Dennis C. Kuo, MD, Linda S. Sorkin, PhD, and Timothy J. Furnish, MD)

Chapter 3. Diagnosing Neuropathic Pain State after Peripheral Nerve Injury
(Rajiv Reddy, MD, and Jeffrey Chen, MD)

Chapter 4. Rehabilitation Strategy after Peripheral Nerve Injury
(Xiaoning Yuan, MD, PhD and Michael T. Sein, MD)

Chapter 5. Analgesics for Post-Traumatic Peripheral Neuropathic Pain Management
(Sepehr Rejai, MD, and Gregory Polston, MD)

Chapter 6. Interventional Procedures for Post-Traumatic Peripheral Neuropathic Pain
(Zachary Cohen, MD; Krishnan Chakravarthy, MD, PhD)

Chapter 7. Neuromodulation for Post-Traumatic Neuropathic Pain Management
(Erin Lawson, MD, Benjamin R. Beal, MD, Sharona Ben-Helm, MD, and Mark S. Wallace, MD)

Chapter 8. Complementary and Alternative Therapies for Post-Traumatic Neuropathic Pain
(Christina Ogidan, MD, and Anna Woodbury, MD)

Chapter 9. Behavioral Medicine Strategies for the Management of Post-Traumatic Neuropathic Pain
(Jamie Gannon, PhD, Angelyna Lowe, PhD, and Thomas Rutledge, PhD)

About the Authors


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