Pemphigus Vulgaris: Scientific Basis, Clinical Presentations, Diagnostic Methodology and Management Strategies


Series: Dermatology – Laboratory and Clinical Research
BISAC: MED017000

This book gathers all up-to-date information regarding the historical perspectives, clinical manifestations, pathomechanism, diagnostic methodology, and therapeutic strategies for a life-threatening, blistering skin disease called pemphigus vulgaris. The medical community has come a long way in discovering its disease mechanism down to the molecular level and found excellent treatment options for patients suffering from this horrific disease. Compared to the pre-corticosteroid era when the mortality rate was greater than 90% to present day mortality, which is extremely rare, we have indeed made great medical progress toward curing this disease.

The scientific and clinical advancements notwithstanding, patients affected by this disease still face a mortality rate two to three times higher than the general population, indicating that the research of this disease has not yet been completed. While this book is focused on pemphigus vulgaris, it also includes four clinical variants of pemphigus vulgaris: drug-induced pemphigus, paraneoplastic pemphigus, pemphigus vegetans, and IgA pemphigus. Accompanied with extensive reviews of scientific literature are clinical photos illustrating the various clinical presentations of the disease, as well as histological and immunohistological patterns of this disease that would serve as outstanding references for practical usage in emergency rooms, hospitals, and outpatient clinics.

This book is intended for: medical students whom require comprehensive knowledge of a well-classified organ-specific autoimmune disease; dermatology residents solidifying their ability to diagnose and treat this group of patients; practicing physicians whom need to update their skills in managing patients suffering from this disease; emergency physicians in order to properly triage their patients; scientists completing their understanding of the disease pathophysiology; and pharmaceutical industries searching for even better treatment options for these patients.
(Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1. Historical Perspective

Chapter 2. Key Developments in Diagnosis and Treatment

Chapter 3. Key Developments in Pathogenesis Understanding

Chapter 4. Clinical Manifestations

Chapter 5. Clinical Variants

Chapter 6. Diagnostic Methodology

Chapter 7. Therapeutic Strategies



“This treatise is both a concise and comprehensive distillation of knowledge from a highly experienced pemphigus specialist. Whether its current views on pathophysiology, clinical diagnosis or therapeutic strategies, this monograph is packed full of helpful advice and pearls of wisdom. This monograph would be equally useful either as a great learning resource for students as well as a detailed reference for seasoned practitioners.” – <strong>M. Peter Marinkovich, MD, Associate Professor, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA</strong>

“Dr. Chan has created a review of pemphigus that will be valued by both the expert and the novice. He chronicles a rich history and clinical application of scientific exploration. He synthesizes both clinical and laboratory information into a coherent understanding of pathogenesis and approach to treatment. This lofty objective can only be achieved by an experienced physician who is dedicated to science and to patient care.” – <strong>John J. Zone, MD, Professor and Chairman, Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</strong>

“Pemphigus is a potentially life-threatening disease that has challenged physicians for decades. This monograph is down to the point, yet contains all necessary details on the pathogenesis of pemphigus and its clinical management.” – <strong>Detlef Zillikens, MD, Professor and Chairman, Department of Dermatology, University of Luebeck School of Medicine, Leubeck, Germany</strong>

Additional Information

Potential Readership: medical students, dermatology residents, physicians in the emergency room, practicing dermatologists, research scientists, immunologists, pharmaceutical scientists

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