Pathogenesis of Neurotrauma and Stroke: New Directions for Neuroprotective and Neuroregenerative Treatments


Jacek M. Kwiecien, DVM, MSc, PhD – Associate Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

Series: Pathology and Laboratory Medicine
BISAC: EDU046000; HEA039110; MED067000
DOI: 10.52305/XJOV2613

This book was written by a veterinary pathologist with an unlimited curiosity directed at the mechanisms of a disease studied in animal models. Despite its evidently ancient origin and distinct presentation; the paralysis, urinary incontinence, and the lack of improvement in motor and sensory deficits, the pathogenesis of the spinal cord injury (SCI) remained poorly understood. This unacceptable ignorance persisted despite vigorous research efforts in the field of SCI mandated by increased public awareness in the last few decades. The lack of understanding of the pathogenesis of SCI, the traumatic brain injury (TBI) and stroke has maintained a peculiar conundrum where the most important group of incurable diseases in medicine combined with a very high cost of medical care persisted well into the 21st century. This book seeks to ‘open the door’ for the medical and scientific fields to a better understanding of the pathogenesis of neurotrauma and stroke with anticipated effective treatments for tens of millions of patients every year.

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Table of Contents


Chapter 1. Introduction

Chapter 2. Pathogenesis of Neurotrauma and Stroke in the Rat Model of Spinal Cord Injury

Chapter 3. Systemic Administration of Xanthohumol Accelerates Elimination of Inflammation in the Spinal Cord Injury

Chapter 4. Bridging the SCI Lesion to Promote Neuroregeneration

Chapter 5. Safe Removal of Myelin by the Intraspinal Infusion of Kynurenic Acid Induces Neuroplasticity and Enables Neuroregeneration

Chapter 6. Robust Axonal Regeneration in Spinal Cord Injury Supported by Schwann Cells

Chapter 7. Analytic Methods in the Rat Model of Spinal Cord Injury

Chapter 8. Perspectives



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