Pathobiology of Hepatocellular Carcinoma and Clinical Impact

Antonio Mazzocca, Pasquale Agosti and Carlo Sabbà
Interdisciplinary Department of Medicine, University of Bari School of Medicine, Piazza G. Cesare, Bari, Italy

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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This book offers a comprehensive review on hepatocellular carcinoma (HCC) with a particular focus on the relationship between the pathobiology of disease and the clinical aspects including diagnosis and treatment. HCC is becoming one of the most common causes of cancer related death worldwide and is predicted to be the third leading cause of cancer death by 2030. In recent years, the epidemiology of this tumor has undergone a major change, a revolution considering the increased incidence of HCC on NASH and NAFLD in patients with metabolic risk factors. We are witnessing the emergence of new cancer risk factors and new pre-cancerous conditions, especially in countries with a Western lifestyle. Many exciting discoveries in the field of pathogenesis and mechanisms of carcinogenesis have taken place in recent years, including findings from tumor interactions with the host and the microenvironment.

This book aims to provide researchers, medical students and clinicians with a valuable resource for complete and up-to-date research on the pathogenesis of HCC by providing a link between biology and natural history of the disease with clinical implications, including diagnosis, prognosis and therapy. This book offers an in-depth knowledge of HCC pathobiology as well as hints for developing new experimental research lines aiming to improve the understanding and management of the disease, and to prevent the increase of incidence and mortality expected in 2030. (Imprint: Nova Biomedical)

Author Biography



Introduction to Hepatocellular Carcinoma (HCC)

Chapter 1. Pathobiology of HCC: The Role of Risk Factors

Chapter 2. Natural History of HCC

Chapter 3. Pathobiology of HCC: The Role of Genetic and Epigenetic Factors

Chapter 4. Pathobiology of HCC: The Role of Microenvironment

Chapter 5. HCC Heterogeneity

Chapter 6. Clinical Aspects of HCC: The Screening

Chapter 7. Clinical Aspects of HCC: The Prognosis

Chapter 8. Clinical Aspects of HCC: The Prevention

Chapter 9. Clinical Aspects of HCC: The Therapy



Audience: Researchers, academic people, medical students and clinicians

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