Paclitaxel: Biosynthesis, Mechanisms of Action and Clinical Uses


Diego Morales (Editor)
CIAL – Research Institute in Food Science (UAM-CSIC), Department of Production and Characterization of Novel Foods, Madrid, Spain

Series: Pharmacology – Research, Safety Testing and Regulation, Cancer Etiology, Diagnosis and Treatments
BISAC: MED071000

Paclitaxel is an antimitotic drug that promotes microtubule polymerization and produces sensitization to radiation. Paclitaxel is a first-line drug for the treatment of non-small cell lung cancer and is used to treat metastatic ovarian cancer, breast cancer, head and neck cancer, and advanced cases of Kaposi’s sarcoma. In this book, the authors discuss the biosynthesis, mechanisms of action and clinical uses of paclitaxel.

Topics include paclitaxel resistance and overcoming strategies with structurally or functionally related drugs; molecular mechanisms that mediate resistance to paclitaxel in cancer; the biosynthesis of paclitaxel and its pharmaceutical application for cancer treatment; current status and clinical trials of paclitaxel-containing therapy for urothelial cancer; mesenchymal stromal cells used for carrying and delivering paclitaxel; and the role of paclitaxel in ovarian cancer. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – Paclitaxel Resistance and Overcoming Strategies with Structurally- or Functionally-Related Drugs
(Jasna Banković, Ana Podolski-Renić, Milica Pešić, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia)

Chapter 2 – Molecular Mechanisms that Mediate Resistance to Paclitaxel in Cancer
(Rishil J. Kathawala, Charles R. Ashby Jr., Zhe-Sheng Chen, Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York, NY, USA)

Chapter 3 – Biosynthesis of Paclitaxel and its Pharmaceutical Application for Cancer Treatment
(Vesna D. Nikolic, Ivan M. Savic, Ljubisa B. Nikolic, Ivana M. Savic, Faculty of Technology, University of Nis, Bulevar oslobodjenja, Leskovac, Serbia)

Chapter 4 – Current Status and Clinical Trials of Paclitaxel-Containing Therapy for Urothelial Cancer
(Yasuyoshi Miyata, Hideki Sakai, Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan)
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Chapter 5 – Mesenchymal Stromal Cells Used for Carrying and Delivering Paclitaxel
(Augusto Pessina, Arianna Bonomi, Emilio Ciusani, Luisa Pascucci, Eugenio Parati, Giulio Alessandri, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy, and others)

Chapter 6 – The Role of Paclitaxel in Ovarian Cancer
(Mariko Shindo, Kiyoshi Yoshino, Yutaka Ueda, Tadashi Kimura, Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, Yamadaoka, Osaka, Japan)


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