Ovarian Reserve: Current Trends and Applications


Series: Obstetrics and Gynecology Advances
BISAC: MED033000
DOI: 10.52305/XAWD3565

This is the first book that provides a comprehensive and in-depth account of the current state of knowledge on the ovarian reserve and its clinical applications in gynaecology and reproductive medicine. “Ovarian reserve” is a term commonly used to reflect the total number of remaining primordial follicles, which determines a woman’s fertility potential. Since its emergence in the late 1980s during the early days of assisted reproduction technology, the concept of ovarian reserve has continued to gain importance in clinical practice and research, as reflected by the exponentially growing number of publications on the topic. A wide range of ovarian reserve markers have been introduced over the years, starting with serum follicle stimulating hormone level in 1988 and most recently anti-Müllerian hormone in 2002. This book starts with a detailed background on the physiology of the ovarian reserve including early ovarian development, follicular dynamics, and the natural history of primordial follicles. This is followed by a comprehensive account of the various biochemical, sonographic, and dynamic markers and their current applications. A special chapter is devoted to anti-Müllerian hormone, which is the most extensively researched and widely used ovarian reserve marker. The role of anti-Müllerian hormone and its clinical utility in polycystic ovarian syndrome is presented in a separate chapter. The book then explores the clinical applications of ovarian reserve testing in various reproductive disorders, including early ovarian aging, diminished ovarian reserve (pathological and iatrogenic), poor ovarian response during assisted reproduction technology, and premature ovarian insufficiency.

Table of Contents

Table of Contents

Chapter 1. Introduction: The Concept of Ovarian Reserve

Chapter 2. Natural History of the Primordial Follicles

Chapter 3. Ovarian Reserve Testing

Chapter 4. Anti-Müllerian Hormone

Chapter 5. Anti-Müllerian Hormone and Polycystic Ovarian Syndrome

Chapter 6. Diminished Ovarian Reserve

Chapter 7. Ovarian Reserve and IVF: The Problem of Poor Ovarian Response

Chapter 8. Premature Ovarian Insufficiency



“An excellent book on ovarian reserve, concisely written, well referenced, with balanced views and containing many practical tips. It is a must read for clinicians practising reproductive medicine.” -Professor Tin Chiu Li, PhD, Professor of Obstetrics, Gynaecology and Reproductive Medicine, Director of the Assisted Reproductive Technology Unit at the Prince of Wales Hospital, The Chinese University of Hong Kong

“The concept of ovarian reserve is central to reproductive medicine and management of infertility. This concise yet comprehensive monograph offers the reader an up to date and readable summary of our knowledge of ovarian reserve and its measurement in 2021. As couples increasingly defer their decisions to start a family, assessment of ovarian reserve has become a mainstay of clinicians ability to advise on topics such as oocyte or embryo freezing, when to try for pregnancy naturally and when to discontinue IVF treatment. Modern approaches using serum AMH and ultrasound assessment of AFC require detailed clinical knowledge to facilitate accurate interpretation of test results, making the contents of this book invaluable to both primary care physicians and those specialising in obstetrics and gynaecology and reproductive medicine. In addition, the more specialised content focussing on clinical implications of diminished ovarian reserve will be of use to those involved in management of early onset of menopause in addition to reproductive medicine specialists. It is also pleasing to see clear advice on what tests not to use. Having read this monograph, the reader will be confident to approach these common and often mismanaged clinical conundrums.” -William Ledger, Professor of Obstetrics and Gynaecology, University of New South Wales, Sydney

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