Table of Contents
Preface
Chapter 1. Ovarian Cancer Pathology and Surgery, Historical Pearls from the Pioneering Greeks and the General Term Gynecologic Cancer to Modern Histopathology and Ovarian Malignancy
G. Tsoucalas1, MD, PhD, C. Iavazzo2, MD, PhD, and M. Karamanou3, MD, PhD
1Anatomy Department, Democritus University of Thrace, Alexandroupoli, Greece
2Gynecologic Oncology Department, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece
3History of Medicine and Medical Deontology, Medical School of University of Crete, Heraklion, Greece
Chapter 2. Ovarian Cancer Screening
Aleksandra Gentry-Maharaj1,2 and Aarti Sharma3
1Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK
2Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, UK
3Department of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK
Chapter 3. The Role of Ultrasounds in the Diagnosis and Management of Adnexal Tumours
Natalie Nunes1, MD, PhD, MRCOG and Davor Jurkovic2, MD, PhD, FRCOG
1Department of Obstetrics and Gynaecology, West Middlesex University Hospital, Chelsea and Westminster Hospital Foundation Trust, London, UK
2Institute for Women’s Health, University College Hospital, London, UK
Chapter 4. Preoperative Biomarkers to Predict Resectability of Patients with Ovarian Cancer
Valerio Mais1, MD, PhD, Michele Peiretti1, MD, PhD, Daniela Fanni2, MD, PhD, Maria Luisa Fais1, MD,
Giulia Carboni1, MD, Giuseppe Deo1, MD, Giuseppina Fais1, MD, and Stefano Angioni1, MD, PhD
1Department of Surgical Sciences, Division of Gynecology and Obstetrics, University of Cagliari, Cagliari, Italy
2Department of Medical Sciences and Public Health, Division of Pathology, University of Cagliari, Cagliari, Italy
Chapter 5. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) Findings in Ovarian Cancer
Skouras Ioannis1, MD, Kokkali Kalliopi2, MD, and Fotiou Alexandros2, MD
1Department of Radiology, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece
2Department of Gynecologic Oncology, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece
Chapter 6. The Role of 18FDG PET/CT Scans in Ovarian Cancer Patients
Lydia Iordanidou, MD, PhD
Department of Nuclear Medicine, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece
Chapter 7. The Pathogenesis of Ovarian Cancer
Victoria Psomiadou, MD
Department of Gynecologic Oncology, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece
Chapter 8. Inherited Ovarian Cancer-Linked Syndromes and Management
Malcolm Scott1, Adam Rosenthal1, PhD, and Terri McVeigh2, PhD
1University College London Hospitals NHS Foundation Trust and UCL Elizabeth Garrett Anderson Institute for Women’s Health, London, UK
2Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, London, UK
Chapter 9. Pathology of Epithelial Ovarian Tumors
Helen J. Trihia, MD, PhD
Department of Pathology ‘Metaxas’ Cancer Hospital, Piraeus, Greece
Chapter 10. Pathology of Non-Epithelial Ovarian Tumours
Christos Iavazzo1, MD, PhD, Alexandros Fotiou1, MD, John Spiliotis2, MD, PhD, and Agathi Kondi-Pafiti3, MD, PhD
1Department of Gynecologic Oncology, “Metaxa” Memorial Cancer Hospital, Piraeus, Greece
2Department of Surgical Oncology and HIPEC, European Interbalkan Medical Center, Thessaloniki, Greece
3Department of Pathology, Aretaieion Hospital, University of Athens, School of Medicine, Athens, Greece
Chapter 11. The Role of Immunohistochemistry in Ovarian Tumours
Christos Valavanis, Efthymia Souka and Gabriela-Monica Stanc
Department of Pathology, Molecular Pathology Unit, ‘Metaxa’ Cancer Hospital of Piraeus, Piraeus, Greece
Chapter 12. Molecular Pathology of Epithelial Ovarian Tumours
Christos Valavanis, MD, Efthymia Souka, MD, and Gabriela-Monica Stanc, MD
Department of Pathology, Molecular Pathology Unit, ‘Metaxa’ Cancer Hospital, Piraeus, Greece
Chapter 13. An Approach to Borderline Ovarian Tumors
Maria Luisa Fais1, MD, Giorgio Candotti2, MD, Giulia Carboni1, MD, Giuseppe Deo1, MD, Giuseppina Fais1, MD, Valerio Mais1, MD, PhD, Stefano Angioni1, MD, PhD and Michele Peiretti1, MD, PhD
1Department of Surgical Sciences, Division of Gynecology and Obstetrics, University of Cagliari, Italy
2Obstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
Chapter 14. Prophylactic Salpingo-Oophorectomy in High-Risk Patients
Paul I. Stanciu, MD, PhD and Sabina Mistry, MD
Gynaecological Oncology Department, West Hertfordshire Hospitals, NHS Trust, UK
Chapter 15. The Management of Early-Stage Epithelial Ovarian Cancer
Virginia García Pineda, MD, PhD, Violeta Romero, MD, PhD, and Ignacio Zapardiel, MD, PhD
Gynecologic Oncology Unit, La Paz University Hospital, Madrid, Spain
Chapter 16. Fertility Sparing in Ovarian Cancer Patients
Myriam Gracia, MD, PhD, Ana Peralbo, MD, PhD and Ignacio Zapardiel, MD, PhD
Gynecologic Oncology Unit, La Paz University Hospital, Madrid, Spain
Chapter 17. The Local-Regional Control of Ovarian Cancer
Paul H. Sugarbaker, MD, FACS, FRCS
Program in Peritoneal Surface Oncology, Washington Cancer Institute, Washington, DC, USA
Chapter 18. Surgical Management of Advanced Epithelial Ovarian Cancer
Fuat Demirkiran, MD, PhD and Ipek Betül Özçivit, MD, PhD
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
Chapter 19. Primary Versus Interval Debulking Surgery in Ovarian Cancer Patients
Yusuf Yildirim, MD, PhD, and Volkan Karatasli, MD, PhD
OncoSurgery Private Clinic, Tepekule Congress Center, Bayrakli, Izmir, Turkey
Chapter 20. Lymphadenectomy in Ovarian Cancer Surgery
Fuat Demirkiran, MD, PhD and Elif Akşahin, MD, PhD
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
Chapter 21. Serous Papillary Primary Peritoneal Carcinoma
Marcello Deraco1, MD, Navinakathiresu Muthukumarasamy2, MD, Dario Baratti1, MD, Marcello Guaglio1, MD and Shigeki Kusamura1 MD, PhD
1Peritoneal Surface Malignacies Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
2ESPSO Fellow from Hospital Selayang, Lebuhraya Selayang-Kepong, Batu Caves, Selangor Malaysia Hospital, Selayang, Selagor, Malaysia
Chapter 22. Ovarian Carcinosarcoma
Ilker Kahramanoglu1, MD, PhD and Olcay Ilhan2, MD, PhD
1Emsey Hospital, Department of Gynecologic Oncology, Istanbul, Turkey
2Diyarbakir Gazi Yasargil Training and Research Hospital, Department of Gynecologic Oncology, Diyarbakir, Turkey
Chapter 23. Krukenberg Tumors
Federico Coccolini1, MD, Riccardo Guelfi1, MD, Enrico Cicuttin1, MD, Camilla Cremonini1, MD, Dario Tartaglia1, MD, Marta Carretto2, MD, Tommaso Simoncini2, MD, and Massimo Chiarugi1, MD
1General, Emergency and Trauma Surgery Department, Pisa University Hospital, Pisa, Italy
2Gynecology Department, Pisa University Hospital, Pisa, Italy
Chapter 24. Pseudomyxoma Peritonei
John Spiliotis1, MD, PhD, Alexandros Fotiou2, MD, and Iavazzo Christos2, MD, MSc, PhD
1Department of Surgical Oncology and HIPEC, European Interbalkan Medical Center, Thessaloniki, Greece
2Department of Gynecologic Oncology, “Metaxa” Memorial Cancer Hospital, Piraeus, Greece
Chapter 25. Ovarian Malignancies During Pregnancy
Miriam Turiel Miranda, MD, Ignacio Cristobal, MD, Elena Martin-Boado, MD, and Ignacio Zapardiel, MD, PhD
Gynecologic Oncology Unit, La Paz University Hospital, Madrid, Spain
Index
