Ototoxicity: Signs, Symptoms and Treatment


Gregg Colon (Editor)

Series: Otolaryngology Research Advances
BISAC: MED066000

This compilation focuses on ototoxicity, the adverse pharmacological reaction affecting the inner ear or auditory nerve, characterized by cochlear or vestibular dysfunction. Although ototoxic medications play an essential role in modern medicine, they can cause harm and lead to significant morbidity.

The authors discuss aminoglycoside antibiotics, loop diuretics, platinum-based chemotherapeutic agents, macrolide antibiotics and antimalarial medications which are among the 600 frequently used ototoxic drugs.

Next, an overview of cisplatin-associated ototoxicity, namely its clinical features, incidence rates, molecular and cellular mechanisms and risk factors is provided for health care practitioners managing patients with cancer.

Ototoxicity and neurotoxicity are defined from the perspective of chemical agents, nicotine and cotinine, that individuals experience through cigarette smoking and environmental tobacco smoke exposure. Mechanisms for toxicity are described by review of animal and human studies revealing changes in peripheral and central auditory structures after exposure to nicotine.

The mechanisms of ototoxicity induced by aminoglycoside are also discussed, as well as the usage of these drugs for treatment of several disorders such as Meniere disease, and possible protective agents.

In closing, the authors highlight the serious issue of aminoglycoside mediated hearing loss in cystic fibrosis patients, and also discuss alternative approaches for avoiding aminoglycoside-induced cochleotoxicity.
(Imprint: Nova Medicine and Health)

Table of Contents

Table of Contents


Chapter 1. Ototoxicity: Pathophysiology, Monitoring and Prevention
(Pavlos Pavlidis, PhD, ENT-Clinic, Klinikum Wolfsburg, Germany)

Chapter 2. Ototoxic Drugs, Diagnosis and Monitoring
(Yüksel Toplu MD, and Mehmet Tan, MD, Inonu University, Medical Faculty, Department of Otorhinolaryngology, Malatya, Turkey)

Chapter 3. Cisplatin Associated Ototoxicity: Considerations for the Health Care Professional
(Jessica Paken, Cyril D. Govender, Mershen Pillay, DEd, Birhanu T. Ayele, PhD, Vikash Sewram, PhD, Discipline of Audiology, School of Health Sciences, University of KwaZulu-Natal, South Africa, and others)

Chapter 4. Ototoxicity and Neurotoxicity Due to Environmental Contaminants: Auditory Impact of Cigarette Smoking and Secondhand Smoke Exposure
(Ishara Ramkissoon, Department of Speech Pathology and Audiology, University of South Alabama, Mobile, AL, US, and others)

Chapter 5. Ototoxicity of Aminoglycoside
(Ela Araz Server and Cigdem Kalaycik Ertugay, Associate Professor, Istanbul Education and Research Hospital, Department of Otorhinolaryngology/Head and Neck Surgery, Istanbul, Turkey, and others)

Chapter 6. Aminoglycoside Mediated Ototoxicity and Hearing Loss in Cystic Fibrosis Patients: An Unmet Medical Need
(Rahul Mittal, Luca H. Debs and Kalai Mathee, Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, US, and others)


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