Osteoclasts: Morphology, Functions and Clinical Implications


Alexander J. Brown (Editor)
Johanna S. Walker (Editor)

Series: Cell Biology Research Progress, Human Anatomy and Physiology
BISAC: SCI017000

Osteoclasts are highly specialized cells, derived from the hematopoietic lineage, that resorb mineralized bone matrix. Osteoclast precursors can be recruited to the bone remodeling sites by specific cytokines in the microcellular environment, including some secreted by osteoblasts, fibroblasts, and osteocytes. In this book, the authors present current research in the study of the morphology, functions and clinical implications of osteoclasts. Topics include osteoclast formation and function and its risk in skeletal bone disease; the high osteoclastogenic potential of human osteosarcoma cells; osteoclast biology regarding Paget’s disease and p62 mutations; the role of immuno-skeletal interface in the regulation of osteoclast formation; and osteoclasts in patients with neurofibromatosis 1. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Modulation of Osteoclast Differentiation and Function in Rheumatoid Arthritis
(Roya Lari, Department of Biology, Ferdowsi University of Mashhd, Mashhad, Iran)

Osteoclast Formation and Function and its Role in Skeletal Bone Disease
(Monique Bethel, Angela Bruzzaniti, Melissa A. Kacena, Departments of Orthopaedic Surgery, Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA, and others)

The High Osteoclastogenic Potential of Human Oteosarcoma Cells: Reciprocal Interaction between MG63 Osteoblast-Like Cells and Osteoclast Precursors
(J. Costa-Rodrigues, M.H. Fernandes, Faculdade de Medicina Dentária, Universidade do Porto, Portugal)

Osteoclast Biology in Paget’s Disease of Bone
(Stephen McManus, Lyne Bissonnette, Sophie Roux, Division of Rheumatology, Faculty of Medicine, University of Sherbrooke, North,Sherbrooke, PQ, Canada)
Free Download Available 

Osteoclasts: The Major Actors in Bone Resorption
(Lucia D’Amico, Ilaria Roato, CeRMS, A.O.U. San Giovanni Battista, Turin, Italy)

Role of the Immuno-Skeletal Interface in Physiological and Pathological Osteoclast Regulation
(M. Neale Weitzmann, The Atlanta Department of Veterans Affairs Medical Center, Decatur, Georgia, USA, and others)

Multiple Functions of Osteoclasts and Potential Usefulness of Phosphatidylserine-Containing Liposomes on Bone Diseases
(Zhou Wu, Hiroshi Nakanishi, Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan)

Bone Formation and Osteoclastic Resorption after Implantation of B-Tricalcium Phosphate (B-TCP)
(Takaaki Tanaka, Masaaki Chazono, Seiichiro Kitasato, Atsuhito Kakuta, Keishi Marumo, NHO Utsunomiya National Hospital, Department of Orthopaedic Surgery, Jikei University School of Medicine, Shimo-Okamoto, Utsunomiya City, Tochigi, Japan)

Osteoclasts of Patients with Neurofibromatosis 1 (NF1)
(Eetu Heervä, Juha Peltonen, University of Turku, Department of Cell Biology and Anatomy, Turku, Finland)
Free Download Available



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