Osteoclasts: Cell Biology, Functions and Related Diseases


Cecelia Reeves (Editor)

Series: Cell Biology Research Progress
BISAC: MED092000

Bone mass is maintained by two specialized types of cells: bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoclasts are tartrate-resistant acid phosphatase-positive, multinucleated giant cells that originate from the monocyte/macrophage lineage of hematopoietic stem cells. Chapter one of this book describes the role miRNAs have in osteoclast differentiation and function.

Chapter two investigates how the inhibition of complement activity influenced joint destruction in relation to osteoclast differentiation. Chapter three is a discussion on the effect of sepsis and bacterial infection on immune system activation, bone remodeling and osteoclast activation. The final chapter of the book provides a current view of possible roles of DC-STAMP in signaling.
(Imprint: Nova Biomedical)


Table of Contents

Table of Contents


Chapter 1
Roles of MicroRNAs in Osteoclast Differentiation and Function
(Tadayoshi Kagiya, Division of Functional Morphology, Department of Anatomy, Iwate Medical University, Iwate, Japan)

Chapter 2
Osteoclast Formation is Delayed in the Absence of Functional Complement Activity in a Model of Rheumatoid Arthritis
(Petya Ganova, Valeriya Gyurkovska and Nina Ivanovska, Department of Immunology, Institute of Microbiology, Sofia, Bulgaria)

Chapter 3
The Effect of Sepsis and Bacterial Infection on Immune System Activation, Bone Remodeling and Osteoclast Activation
(Hwei-Fang Tsai, Department of Internal Medicine Taipei Medical University-Shaung Ho Hospital, New Taipei City, Taiwan, Graduate Institute of Medical Research Taipei Medical University, Taipei, Taiwan)

Chapter 4
DC-STAMP: Regulator of Cell Fusion & Bone Homeostasis
(Ya-Hui Grace Chiu & Christopher T. Ritchlin, Allergy/Immunology & Rheumatology Division, University of Rochester, Rochester, NY, USA)



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