Osteoclastogenesis: Research Advances and Clinical Challenges

Masayoshi Yamaguchi, Ph.D. (Editor)
Department of Hematology and Medical Oncology, Emory University, School of Medicine, Atlanta, Georgia, USA

Series: Human Anatomy and Physiology
BISAC: MED075000

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$95.00

Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Bone is a dynamic tissue that undergoes continual adaptations during a vertebrate’s lifespan to attain and preserve skeletal size, shape, and structural integrity, and plays a pivotal role in regulating mineral homeostasis in a living body. Bone homeostasis, which maintains bone mass, is artfully regulated through osteoclasts, osteoblasts and osteocytes in bone tissues. This mechanism is regulated through many hormones, cytokines and immune systems in the bone marrow microenvironment. Aging leads to a reduction in bone mass, which is reduced by a suppression of osteoblastic bone formation and an enhancement in osteoclastic bone resorption. A decrease in bone mass leads to osteoporosis and bone fracture. Osteoporosis is widely recognized as a major public health problem. Moreover, bone loss is shown to stimulate in various pathophysiological states, including inflammation, obesity, diabetes, and cancer cell bone metastasis. Disease associated with bone loss is strongly related to osteoclastic bone resorption. This book focuses recent research topics implicated in osteoclastogenesis and clinical challenges to prevent and treat bone loss. (Imprint: Nova Biomedical)

Preface

Chapter 1. Osteoclast Fusion: An Important Biological Behavior for Osteoclast Function
Ce Dou and Shiwu Dong (Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing, China)

Chapter 2. Osteoclastogenesis: The Role of Regucalcin as a Novel Stimulator like Cytokine
Masayoshi Yamaguchi (Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, US)

Chapter 3. Osteoclastogenesis and Drug Discovery
Yan-Qiu Liu and Xue Deng (Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, China)

Chapter 4. Some Plant-Derived Natural Products Inhibited Osteoclast Formation and Function
Yueqi Chen and Shiwu Dong (Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing, China)

Chapter 5. A New Approach to Osteoporosis Treatment: Suppression of Osteoclastic Bone Resorption with Nutritional and Botanical Factors
Masayoshi Yamaguchi (Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA)

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