Organic and Medicinal Chemistry. Volume 2

Bimal Krishna Banik, Ph.D. (Editor)
Professor, Deanship of Research Development; Department of Mathematics and Natural Sciences; College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar, Kingdom of Saudi Arabia

Series: Chemistry Research and Applications
BISAC: SCI013040

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Organic and medicinal chemistry are definitely the principal branches of chemistry as they are more widely studied than any other subjects in chemistry. Very often, organic and medicinal chemistry have been defined as a hybrid discipline of many other subjects that include biology, chemistry, medicine and pharmacy. The synthesis of molecules, mechanism of a process, studies of new reagents, natural products, biological and pharmacological evaluation of molecules against different components of cells are the key subjects in these two areas. On the basis of unlimited possibilities, one can imagine several scopes exist for students, researchers and industrialists to study and explore organic and medicinal chemistry. In this book, an attempt has been made to include diverse research topics to benefit the readers from different standpoints. This book has nine chapters (Volume 2) from active authors.

Bhalla and his group have written two chapters in this volume. In the first chapter, Berry and Bhalla have demonstrated recent progress on the pharmacological profile of pyrazole and imidazole conjugates. In the second chapter, Kumari and Bhalla have explored the synthesis of optically active beta lactams. Sahoo and Banik have explored new quinazolines synthesis and their medicinal and pharmacological properties in Chapter Three. Perchyonok has described natural biomaterials for veterinary therapy through an in vitro approach in the fourth chapter. In the fifth chapter, Perchyonok et al. have also reported studies on cytotoxicity biomaterials containing chitosan hydrogels. Philips has demonstrated the synthesis and applications of pharmacologically relevant phosphonates and phosphinites in Chapter Six. Basu and Banik have explored apoptosis in the inhibition of cancer in Chapter Seven. Maji and Ganguly have demonstrated the use of mushrooms as a food in Chapter Eight. Bandyopadhyay et al. have studied key enzymes that are responsible in cancer and their mechanism of action in the ninth chapter.

Scientists are convinced that organic and medicinal chemistry have no boundaries in science. The application of these chemical and medicinal sciences is huge and they are related to many significant discoveries. On this basis, the book will be useful for chemists, biologists, clinicians, pharmacists, biotechnologists, industrialists and engineers who are working in the field of interdisciplinary science as well as specific chemical and medicinal science. (Imprint: Nova)

Preface

Chapter 1. Recent Progress on the Pharmacological Profile of Biodynamic Pyrazole/Imidazole/Benzamidazole-4-Thiazolidinone Conjugates
(Shiwani Berry and Aman Bhalla, Department of Chemistry and Center of Advanced Studies in Chemistry, Panjab University, Chandigarh)

Chapter 2. Recent Advances in Synthesis of Chiral β-Lactams: Potential Bioactive Agents
(Anu Kumari and Aman Bhalla, Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, Punjab, India)

Chapter 3. New Quinazolines: Synthesis, Medicinal and Pharmacological Activities
(Anu Kumari and Aman Bhalla, Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, Punjab, India, and others)

Chapter 4. Natural Biomaterials for Veterinary Therapy From Design to Application: In Vitro Approach
(Victoria Tamara Perchyonok, VTPCHEM PTY LTD, Glenhuntly, Melbourne, Australia)

Chapter 5. Cytotoxicity and Biomaterials Containing Chitosan Hydrogels: Design and Biocompatibility
(Victoria Tamara Perchyonok, Annette Olivier and Sias Grobler, VTPCHEM PTY LTD, Glenhuntly, Melbourne, Australia)

Chapter 6. Synthesis and Applications of Pharmacologically Relevant Phosphonates and Phosphinates
(Ana Maria Madeira Martins Faisca Phillips, Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal)

Chapter 7. Apoptosis: Programmed Cell Death
(Shibani Basu and Bimal Krishna Banik, Department of Chemistry and Biochemistry, ID, US)

Chapter 8. Mushroom: A Magical Medicinal Food for All
(Priyankar Maji and Jhuma Ganguly, Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, India)

Chapter 9. Key Enzymes in Cancer: Mechanism of Action and Inhibition With Anticancer Agents
(Debasish Bandyopadhyay, Gabriel Lopez, Stephanie Cantu, Samantha Balboa, Annabel Garcia, Christina Silva and Diandra Valdes, Department of Chemistry, The University of Texas Rio Grande Valley, Edinburg, Texas, US)

Index

“The new book titled "Organic and Medicinal Chemistry", edited by Dr. Bimal Krishna Banik, covers a very interesting list of topics involving syntheses and applications of compounds such as beta-lactams, pyrimidines, thiazolidinones, quiinazolines, phosphonates, phosphinates, isoxazolines, pyrroles, polyaromatics and glycosides. The applications especially focus on cancer and apoptosis. The book is highly recommended both for both experts and non-experts who are interested in these important areas”. - Arnold L. Demain, Ph. D., RISE Institute of Drew University, Madison, New Jersey, USA

“The edited volume by Dr. Banik is a collection of 18 chapters. The coverage is very broad with topical areas in synthesis of bioactive compounds, heterocyclic/medicinal chemistry, and anticancer agents. It is an informative collection that would benefit researchers working in these areas”. - Kenneth Laali, Ph. D., Presidential Professor, Department of Chemistry, University of North Florida

“I have looked at the contents provided by Dr. Banik. I fully endorse this book. The contents are highly adequate. In my opinion the book is extremely useful for researchers in chemistry all over the world. Each chapter is written by highly competent chemist. Consequently, I highly recommend this book for chemists all over the world.” - Narayan G. Bhat, Ph. D., Professor of Chemistry, UTRGV, Edinburg, TX, USA

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