Nonhuman Primate Models in Preclinical Research. Volume 2: Disease Models

$230.00

Huifang Chen, MD., PhD. (Editor) – Professor of Surgery, Department of Surgery, University of Montreal, Montreal, Quebec, Canada
Jan A.M. Langermans, PhD. (Editor) – Professor, Animal Science Department, Biomedical Primate Research Centre, the Netherlands; Department Population Health Sciences, Divison Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

Series: Animal Science, Issues and Research

BISAC: SCI070050

Despite many encouraging developments in the field of animal-free technologies, well-defined animal models are still needed to study fundamental properties of human diseases and to develop new prophylactic and therapeutic treatments against human diseases. Non-human primates (NHP) make up only a small, but important, part of the total number of animals used in biomedical and preclinical research. Due to their close phylogenetic relationship and the shared susceptibility to many human diseases, NHP can provide important research models to study these diseases and, as such, play a critical role in the advancement of various areas in the medical field. Studies in NHP have contributed to our understanding of various diseases and fundamental biological phenomena and they continue to be important in the development of new therapies, treatments, drugs and vaccines. Moreover, NHP models also contribute to our general knowledge of the processes that underlie non-disease and disease conditions. Important areas where NHP can provide important information include (emerging) infectious diseases, organ transplantation, neurological and aging-related disorders. Although not covered in this book due to time constraints, the need for, and benefits of, NHP models has been demonstrated most recently in the SARS-CoV-2 pandemic.

The present book is the second of two volumes and covers important disease areas where NHP are used as model species. This volume includes different chapters on NHP models in infectious diseases, aging, neurodegenerative disorders, organ transplantation and cancer.

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Table of Contents

Preface

Chapter 1. Viral Diseases in NHPs
(Roger Le Grand – CEA-Université Paris Saclay-Inserm, “Immunology of viral infections and auto-immune diseases”, IDMIT Department, IBJF, France)

Chapter 2. NHP Models for Influenza
(Edmond J. Remarque – Virology Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands)

Chapter 3. Modelling Malaria in Non-Human Primates between 1900 and 2020
(Erica Pasini – Parasitology Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands)

Chapter 4. Aging Research in Nonhuman Primates
(Corinna N. Ross – Department of Science and Mathematics, Texas A&M-San Antonio, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio TX, US)

Chapter 5. Nonhuman Primate Models of Human Autoimmune Diseases
(Jakub Zafar Qazi, Huifang Chen, and Muhammad Zafarullah – Faculté de pharmacie, Pavillon Jean Coutu, Université de Montréal, Montréal, Quebec, Canada, et al.)

Chapter 6. NHP Models in Neurodegenerative Disorders Research
(Ingrid Philippens – Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands)

Chapter 7. Nonhuman Primate Models of Parkinson’s Disease: Improvement in the Understanding of PD Progress and Development of Novel Therapy
(Wenlei Jiang – Laboratory of Experimental Therapeutics, University Health Network, Toronto, Ontario, Canada)

Chapter 8. Nonhuman Primate Models for Beta Cell Replacement in Diabetes Research
(Scott Hunter Oppler and Melanie L. Graham – Preclinical Research Center, Department of Surgery, University of Minnesota, Saint Paul, MN)

Chapter 9. The Nonhuman Primate as a Unique Model to Understand the Pathogenesis of Human Endometriosis
(Ivanela Kondova – Division of Pathology and Microbiology, Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands)

Chapter 10. Nonhuman Primate Models in Organ Transplantation
(Lijun Song – Laboratory of Experimental Surgery, Department of Surgery, CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 11. Nonhuman Primate (NHP) Models in Lung Transplantation
(Junzheng Peng and Huifang Chen – Cardiovascular phenotyping core facility, CRCHUM, University of Montreal, Montreal, Quebec, Canada, et al.)

Chapter 12. NHP Models of Cardio-Cerebrovascular Diseases Research
(Junzheng Peng and Huifang Chen – Cardiovascular phenotyping core facility, CRCHUM, University of Montreal, Montreal, Quebec, Canada, et al.)

Chapter 13. NHP Models of Cancers
(Xiaoya Duan and Yanxin Hu – School of Life Sciences, East China Normal University, Shanghai, China, et al.)

Index

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