Nonhuman Primate Models in Preclinical Research. Volume 1: Basics and Regulatory Principles

$195.00

Huifang Chen, MD., PhD (Editor) – Professor of Surgery, Department of Surgery, University of Montreal, Montreal, Quebec, Canada
Jan A.M. Langermans, PhD (Editor) – Professor, Animal Science Department, Biomedical Primate Research Centre, the Netherlands; Department Population Health Sciences, Divison Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

Series: Animal Science, Issues and Research

BISAC: SCI070050

Target Audience: Physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and researchers.

Description:

Due to the phylogenetic relationship and close genetic and biological similarities with humans, non-human primates (NHP) are regularly used in biomedical and behavioural research. However, because of their highly developed cognitive abilities and social skills, the use of these animals in biomedical research is debated more and more. Although it is acknowledged that in specific research areas NHP are still essential, it is recognized that the use of these animals can only be done under strict conditions under the most optimal welfare aspects. Welfare aspects include housing conditions, non-invasive methods and application of the 3Rs policy. Although many refinement methods have been described in nationally and internationally accepted guidelines on animal laboratory practice, recognition of the guidelines is unfortunately not universal.

The present book covers a wide range of NHP models in preclinical research and welfare issues. The following chapters will cover: refinement of the use of NHP in biomedical research; NHP ethics and regulations in Europe; biological basis differences in the human and NHP; the major histocompatibility complex (MHC) immunology in NHP; stem cell biology in NHP; neuro and gliogenesis in an NHP ischemia stroke model; NHP models in autoimmune disease, organ transplantation and infectious disease research; viral diseases in NHP; NHP models in Parkinson’s disease, in neurodegenerative disorders research and in cardio-cerebrovascular disease research; islet transplantation; ophthalmic diseases research and neurophysiology in NHP; transgenic engineering in NHP; NHP models of cancers; NHP models in respiratory disease research; NHP models in clinical and non-clinical pharmacology; NHP models in lung transplantation; and aging research in NHP. This book encapsulates a large volume of knowledge scientists have achieved in the field of nonhuman primate models in preclinical research.

The editors have invited experts from the United States, Canada, and Europe to contribute 23 chapters in their respective fields of their expertise.

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Table of Contents

Foreword

Preface

Section I: Basic and Regulatory Issues in NHP Preclinical Research

Chapter 1. Refinement of the Care and Use of NHPs in Biomedical Research
(Wenhao Chen, Pierre Daloze, Huifang Chen – Immunobiology & Transplant Science Center, Department of Surgery, Houston Methodist Research Institute, Institute for Academic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA, et al.)

Chapter 2. Ethics and Legal Regulation of Nonhuman primates (NHPs) in Canada
(Junzheng Peng – Cardiovascular phenotyping core facility, CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 3. The Use of Nonhuman Primates: Ethics and Regulations in Europe
(Jan Langermans – Animal Science Department, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288GJ Rijswijk, the Netherlands)

Chapter 4. Biological Basic Differences in the Human and NHPs
(Adam Deak, Zsuzsanna Bodo and Norbert Nemeth – Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, et al.)

Chapter 5. MHC In NHP: From the Perspective of Immunogenetics
(Natasja G. de Groot – Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Rijswijk, the Netherlands)

Chapter 6. Nonhuman Primate Stem Cell Biology
(Jakub Zafar Qazi, Zafarullah, M and Huifang Chen – University of Montreal, Montreal, Quebec, Canada, et al.)

Chapter 7. NHP Models for Influenza
(Ed Remarque – Biomedical Primate Research Centre, Virology Department, Rijswijk, The Netherlands)

Section II. NHP Models in Preclinical Research

Chapter 8. Non-Human Primate Models of Human Autoimmune Diseases
(Jakub Zafar Qazi, Huifang Chen and Muhammad Zafarullah – Faculté de pharmacie, Pavillon Jean Coutu, Université de Montréal, Montréal, Quebec, Canada, et al.)

Chapter 9. Nonhuman Primate Models in Organ Transplantation
(Lijun Song – Laboratory of Experimental Surgery, Department of Surgery, CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 10. Modelling Malaria in NHPs Between 1900-2000
(Erica Pasini – Biomedical Primate Research Centre, Parasitology Department, Rijswijk, The Netherlands)

Chapter 11. Viral Diseases in NHPs
(Roger le Grand, Jan Langermans – CEA-Université Paris Saclay-Inserm, UMR1184 « Immunology of viral infections and auto-immune diseases”, IDMIT Department, IBJF, France, et al.)

Chapter 12. NHP Models in Neurodegenerative Disorders Research
(Ingrid Philippens – Research group Neuroscience, Animal Science Department, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands)

Chapter 13. Nonhuman Primate Models of Parkinson’s Disease: Improvement in the Understanding of PD Progress and Development of Novel Therapy
(Wenlei Jiang – Laboratory of Experimental Therapeutics, University Health Network, Toronto, Ontario, Canada)

Chapter 14. NHP Models of Cardio-Cerebrovascular Diseases Research
(Junzheng Peng and Huifang Chen – Cardiovascular phenotyping core facility, CRCHUM, University of Montreal, Montreal, Quebec, Canada, et al.)

Chapter 15. Nonhuman Primate Models for Beta Cell Replacement in Diabetes Research
(Scott Hunter Oppler and Melanie L. Graham – Preclinical Research Center, Department of Surgery, University of Minnesota, Saint Paul, MN)

Chapter 16. Overview of Imaging Modalities for Nonhuman Primates
(Marieke Stammes – Biomedical Primate Research Centre, Parasitology Department, Rijswijk, the Netherlands)

Chapter 17. Genetic Engineering in Nonhuman Primates and its Impact on Medical Science
(Adam He and Wenhao Chen – Immunobiology & Transplant Science Center, Department of Surgery, Houston Methodist Research Institute, Institute for Academic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA, et al.)

Chapter 18. The Role of Nonhuman Primate (NHP) in Drug Safety Assessment
(Junzheng Peng and Huifang Chen – Cardiovascular phenotyping core facility, CRCHUM, University of Montreal, Montreal, Quebec, Canada, et al.)

Chapter 19. The Nonhuman Primate as a Unique Model to Understand the Pathogenesis of Human Endometriosis
(Ivanela Kondova – Division of Pathology and Microbiology, Animal Science Depertment, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands)

Chapter 20. NHP Models of Cancers
(Xiaoya Duan and Yanxin Hu – School of Life Sciences, East China Normal University, Shanghai, China, et al.)

Chapter 21. Nonhuman Primates in Non-Clinical Development and Translational Research of Medicinal Products and Devices
(Kupa Bilolo – Houston Methodist Hospital, Houston, TX)

Chapter 22. Nonhuman Primate (NHP) Models in Lung Transplantation
(Junzheng Peng and Huifang Chen – Cardiovascular phenotyping core facility, CRCHUM, University of Montreal, Montreal, Quebec, Canada, et al.)

Chapter 23. Aging Research in Nonhuman Primates
(Corinna N. Ross – Department of Science and Mathematics, Texas A&M-San Antonio, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio TX)

Index

Additional information

Binding

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