Nitric Oxide: Emerging Developments, Therapeutic Role in Disease States and Health Effects


Dominic M. Evans (Editor)

Series: Chemistry Research and Applications
BISAC: SCI013000

Nitric oxide (NO) is a pleiotropic free radical messenger molecule. There is enzymatic, non-enzymatic and bacterial production of NO in the human gut. This book examines the role of NO in human gastrointestinal and hepatic physiology and disease processes.

Furthermore, it has long been recognized that nitric oxide is heavily involved in cell signaling. The authors’ examine the complex relationship between S-nitrosylation and cancer biology. Other chapters in this book explore the complexity of NO metabolic pathway in order to better understand its role in the interaction between parasites and host cells; the most promising nanomaterials for the development of electrochemically or optical sensors for in vivo NO sensing and the NO pathway in Trypanosoma cruzi epimastigotes, associated with several diseases considered to be public health concerns.
(Imprint: Nova)

Table of Contents

Table of Contents


Chapter One
Nitric Oxide in Gastrointestinal and Hepatic Disease and Health
(Cong Dai, Yi-ning Li, Wei-xin Liu, Min Jiang and Ming-Jun Sun, Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, China)

Chapter Two
S-Nitrosylation: A Double-Edged Sword in the Progression and Inhibition of Cancer
(Kimberly Hallowell, Laura St. Clair, Dana Jarigese, and Mark A. Brown, Department of Animal Science, Colorado State University, Fort Collins, CO, USA, and others)

Chapter Three
Nitric Oxide and Trypanosomatids: A Tale of Dr. Jekyll and Mr. Hyde
(Fabrino, D.L. and Leon, L.L., Department of Chemistry, Biotechnology and Bioprocess Engineering, UFSJ/CAP, Brazil, and others)

Chapter Four
Nanomaterials for in vivo NO Sensing
(João M. M. Leitão, Eliana F. C. Simões, and Joaquim C. G. Esteves da Silva, Centro de Investigação em Química (CIQ), Faculty of Pharmacy, University of Coimbra, Polo das Ciências da Saúde, Coimbra, Portugal, and others)

Chapter Five
L-arginine Metabolism in the Pathogenic Trypanosomatids Trypanosoma cruzi and Leishmania sp.
(Rodrigues RF, Fabrino DL, Leon LL, Laboratory of Biochemistry of Trypanosomatids, Oswaldo Cruz Institute, FIOCRUZ, Brazil, and others)


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