New Trends in Corynebacterium glutamicum: Beyond the Amino Acids

$275.00

Series: Bacteriology Research Developments
BISAC: SCI006000

More than fifty years of scientific and industrial developments focused on the amino acid producer bacterium Corynebacterium glutamicum has successfully yielded up to 2.93 and 1.95 million tons/year of L glutamic acid and L-lysine, respectively. As a result of this biotechnological effort, a massive amount of knowledge decidedly applicable to the development of new products has been gained. Nowadays, this knowledge is used to enlarge the portfolio of C. glutamicum industrial products, since they are highly relevant as chemicals, biodegradable polymers, ingredients, or additives in food, feed, cosmetics and pharmaceuticals. This book addresses production of these new metabolites (C. glutamicum applications) and their potential under the expert point of view of those groups directly involved in their developments. Thus, amino acids out of the traditional glutamic acid or lysine, as L valine; food colorants such as carotenoids; dicarboxylic acids used as building blocks (e.g: succinate); alpha hydroxy acids as L lactate, D lactate or glycolate; biodegradable polyester (eg.: polyhydroxybutyrate); alcohols for biofuel as isobutanol as well as bioremediation applications of the new developments around C. glutamicum described in this book. Those industrial relevant compounds come to the market parallel with the developing application of new technologies.

Hence, cell activity as a whole by means of the Proteomics or Transcriptomics approaches, as well as the methodologies that mimic the large fermetor conditions in a scale-down format are also reviewed in the book. Additionally, a historical description and an updated review of the taxonomical environment of Corynebacterium genus open an essential manual for enterprises, researchers and academia involved in Actinobacteria, secondary metabolite production and industrial applications. This book reviews the evolution of almost sixty years of development, initially focused on amino acid production, which unleashes the idea of C. glutamicum as a biorefinery due to its ability to generate hundreds of products demanded by the market.

 

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Table of Contents

Table of Contents

Preface
(Carlos Barreiro, Instituto de Biotecnología de León (INBIOTEC), León, Spain)

Chapter 1
Corynebacterium  Genus, a Dual Group of Clinical and Industrial-Relevant Bacteria
(Carlos Barreiro, Juan F. Martín, Instituto de Biotecnología de León (INBIOTEC), León, Spain, and others)

Chapter 2
Deciphering the Dynamic Transcriptome Employing Microarrays
(Rosario Pérez-Redondo, Alberto Sola-Landa, Antonio Rodríguez-García, Instituto de Biotecnología de León (INBIOTEC), León, Spain, and others)

Chapter 3
Methods in Proteomics Applied to Corynebacterium glutamicum
(Carlos Barreiro, Instituto de Biotecnología de León (INBIOTEC), León, Spain, and others)

Chapter 4
Scale-Down Studies of Corynebacterium glutamicum Cultivations for a Consistent Bioprocess Development
(Anja Lemoine, Stefan Junne, Peter Neubauer, Technische Universität Berlin, Department of Biotechnology, Chair of Bioprocess Engineering, Ackerstrasse, Berlin, Germany, and others)

Chapter 5
Carotenoids Biosynthesis in Corynebacterium glutamicum
(Miriam Martínez-Castro, Esther Bahillo, Sonia Martínez-Cámara, José-Luis Barredo, Gadea Biopharma, Parque Tecnológico de León, León, Spain)

Chapter 6
Bio-Based Organic and Hydroxy Acid Production with Corynebacterium glutamicum
(Stefan Wieschalka, Boris Litsanov, Technical University of Denmark, NNFCfB, Hørsholm, Denmark, and others)

Chapter 7
L-Valine production in Corynebacterium glutamicum
(Kazumi Hiraga, Crispinus A. Omumasaba, Masayuki Inui, Research Institute of Innovative Technology for the Earth, Kizugawadai, Kizugawa-shi Kyoto, Japan)

Chapter 8
Isobutanol Production in Corynebacterium glutamicum
(Kazumi Hiraga, Crispinus A. Omumasaba, Masayuki Inui, Research Institute of Innovative Technology for the Earth, Kizugawadai, Kizugawa-shi Kyoto, Japan)

Chapter 9
Anaerobic Production of Organic Acids and Alcohols with Corynebacterium glutamicum
(Stéphane Delaunay, Abdoul Karim Kaboré, Cregut Mickaël, Huang Bao Truc Khuat, Emmanuel Guedon, Laboratoire Réactions et Génie des Procédés, Université de Lorraine, TSA, Vandoeuvre-lès-Nancy Cedex, France)

Chapter 10
Use of Corynebacterium glutamicum  for Heavy Metals Bioremediation: Arsenic as Prototype
(Almudena F. Villadangos, José A. Gil, Luis M. Mateos, Area of Microbiology, Department of Molecular Biology, Faculty of Biology. Campus de Vegazana, University of León, León, Spain)

Index

Reviews

“Corynebacteria have reached a new golden age. This group of bacteria have clinical interest and wide industrial relevance in the production of amino acids, organic acids and carotenoids, among other products. The novel omics tools have a great impact on our knowledge of the corynebacteria molecular genetics and will contribute in the next decades to the rational design of strains of Corynebacterium as a platform for industrial processes.” – Professor Dr. Juan F. Martín, INBIOTEC, Instituto de Biotecnología de León, Parque Científico de León, León, Spain

Additional Information

It is an essential manual for enterprises, researchers and academia involved in Actinobacteria, secondary metabolite production and industrial applications

 

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