New Developments on Signal Transduction Research


Series: Cell Biology Research Progress
BISAC: SCI017000

Signal transduction plays a pivotal role in cell regulation. Hormones, cytokines and neurotransmitters bind to theirspecific receptors in the plasma membranes of cells. The receptors of many hormones are coupled to G-protein coupled signaling pathways. Insulin and growth factors are coupled to receptor-linked kinase. The second messenger is generated in cells once the first messenger binds to the receptors of plasma membranes. Cyclic adenosine monophosphate (cyclic AMP), inositol 1,3,5-triphosphate (IP3) and calcium ion (Ca2+) have been demonstrated to play a role as a second messenger in cells. The pivotal role of Ca2+ in cellular regulation was established with the finding of calmodulin and protein kinase C that modulates the effect of Ca2+ in the regulation of cellular functions. Many receptor classes and their downstream kinases activate Erk, Akt, Stat, Smad, NF-êB and other cascades to regulate gene expression and cellular function. This book provides recent research in the study of the new developments in signaling transduction in cells. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents

Preface pp. i-x

Chapter 1. Signal Transduction Mediated via Extracellular Calmodulin and Extracellular Calmodulin Binding Proteins
(Danton H. O’Day, University of Toronto Mississauga, Mississauga, Ontario, Canada, and others) pp. 1-12

Chapter 2. Kinase Coupled Receptors and G-Protein Coupled Receptors Regulate Neural Stem Cell Differentiation via Common Signaling Pathways: Emerging Evidence for Convergent Regulation
(Shelley B. Hooks, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA)pp. 13-36

Chapter 3. Pheromone Biosynthesis Activating Neuropeptide Receptors (PBANRs) in Moths: New Developments Regarding Alternative Splice Variants and the Potential for Targeted Disruption of PBANR in Pest Control
(J. Joe Hull and Shogo Matsumoto, USDA-ARS, US Arid Land Agricultural Research Center, Maricopa AZ, USA, and others)pp. 37-66

Chapter 4. Cdk5 Acts as a Surveillance System in the Nervous System
(Jared S. Rosenblum, Drexel University, Philadelphia, PA, USA)pp. 67-112

Chapter 5. The Role of Signal Transduction in Abnormal Embryonic Development
(Carolyn M. Kapron, Department of Biology, Trent University, Peterborough, Ontario, Canada)pp. 113-126

Chapter 6. Regucalcin, a Suppressor Protein in Signal Transduction
(Masayoshi Yamaguchi, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA)pp. 127-184

Chapter 7. Isolation and Partial Characterization of Reactive Oxygen Species (ROS) Resistant Mutants with High Yielding in <i>Oryza sativa</i> cv Koshihikari
(Kohji Hasunuma, Yusuke Yoshida, Haruna Matsuya, Ken Nomura, Osamu Miyoshi and Md. Emdadul Haque, Kihara Institute for Biological Research, Yokohama City University, Maioka-cho, Totsuka-ku, Yokohama, Kanagawa, Japan and others)pp. 185-208

Index pp. 209-220


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