New Developments on Signal Transduction Research

Masayoshi Yamaguchi, PhD (Editor)
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), California, USA

Series: Cell Biology Research Progress
BISAC: SCI017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Signal transduction plays a pivotal role in cell regulation. Hormones, cytokines and neurotransmitters bind to their specific receptors in the plasma membranes of cells. The receptors of many hormones are coupled to G-protein coupled signaling pathways. Insulin and growth factors are coupled to receptor-linked kinase. The second messenger is generated in cells once the first messenger binds to the receptors of plasma membranes. Cyclic adenosine monophosphate (cyclic AMP), inositol 1,3,5-triphosphate (IP3) and calcium ion (Ca2+) have been demonstrated to play a role as a second messenger in cells. The pivotal role of Ca2+ in cellular regulation was established with the finding of calmodulin and protein kinase C that modulates the effect of Ca2+ in the regulation of cellular functions. Many receptor classes and their downstream kinases activate Erk, Akt, Stat, Smad, NF-êB and other cascades to regulate gene expression and cellular function. This book provides recent research in the study of the new developments in signaling transduction in cells. (Imprint: Nova Biomedical )

Preface pp. i-x

Chapter 1. Signal Transduction Mediated via Extracellular Calmodulin and Extracellular Calmodulin Binding Proteins
(Danton H. O'Day, University of Toronto Mississauga, Mississauga, Ontario, Canada, and others) pp. 1-12

Chapter 2. Kinase Coupled Receptors and G-Protein Coupled Receptors Regulate Neural Stem Cell Differentiation via Common Signaling Pathways: Emerging Evidence for Convergent Regulation
(Shelley B. Hooks, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA)pp. 13-36

Chapter 3. Pheromone Biosynthesis Activating Neuropeptide Receptors (PBANRs) in Moths: New Developments Regarding Alternative Splice Variants and the Potential for Targeted Disruption of PBANR in Pest Control
(J. Joe Hull and Shogo Matsumoto, USDA-ARS, US Arid Land Agricultural Research Center, Maricopa AZ, USA, and others)pp. 37-66

Chapter 4. Cdk5 Acts as a Surveillance System in the Nervous System
(Jared S. Rosenblum, Drexel University, Philadelphia, PA, USA)pp. 67-112

Chapter 5. The Role of Signal Transduction in Abnormal Embryonic Development
(Carolyn M. Kapron, Department of Biology, Trent University, Peterborough, Ontario, Canada)pp. 113-126

Chapter 6. Regucalcin, a Suppressor Protein in Signal Transduction
(Masayoshi Yamaguchi, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA)pp. 127-184

Chapter 7. Isolation and Partial Characterization of Reactive Oxygen Species (ROS) Resistant Mutants with High Yielding in Oryza sativa cv Koshihikari
(Kohji Hasunuma, Yusuke Yoshida, Haruna Matsuya, Ken Nomura, Osamu Miyoshi and Md. Emdadul Haque, Kihara Institute for Biological Research, Yokohama City University, Maioka-cho, Totsuka-ku, Yokohama, Kanagawa, Japan and others)pp. 185-208

Index pp. 209-220

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