New Developments in Tryptophan Research


Victoria Hayes (Editor)

Series: Biochemistry Research Trends
BISAC: SCI007000

Tryptophan is not only an essential amino acid but also an effective signaling molecule as an indicator of amino acid sufficiency. Serotonin is biosynthesized from the essential amino acid tryptophan. The first chapter of this book deals with the effects of tryptophan as well as some strategies of treatments that modify serotonin levels on cognitive processes during aging and neurodegenerative diseases. The changes of tryptophan metabolism under immunological challenges and physiological conditions like stress are examined as well.

In the third chapter, the authors illustrate the key role of L-tryptophan in metabolic functions with special emphasis on the alterations of circadian rhythms. The remaining chapters of the book focus on new research findings on L-tryptophan synthesis from D-serine; the complex experimental and theoretical studies of the tryptophan molecule in its collisions with low and high energy electrons; and finally, a commentary on a novel tryptophan-selective amino acid transporter that is functionally coupled to ID01-dependent signaling pathways.
(Imprint: Nova)


Table of Contents

Table of Contents


Chapter 1
Positive Effects of Tryptophan and Serotonin on Cognition during Aging and Related-Diseases
(David Moranta, Fiorella Sarubbo, Margarita R. Ramis, Sara Aparicio, Antonio Miralles and Susana Esteban, Laboratory of Neurophysiology, Department of Biology, University of the Balearic Islands, Palma, Spain)

Chapter 2
Kynurenine and Serotonin Pathways of Tryptophan Metabolism: The Etiology and Pathogenesis of Depression
(Sang Won Jeon, and Yong-Ku Kim, Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Republic of Korea)

Chapter 3
L-tryptophan in Perinatal Nutrition, a Putative Role in Circadian Rhythm Acquisition?
(Elizabeth Nascimento, and Bertrand Kaeffer, Departamento de Nutrição, Centro de Ciências da Saude, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil, and others)

Chapter 4
Tryptophanase Enantioselectivity Transforming D-Serine from Inhibitor to Active Substrate in the Presence of Triammonium Phosphate
(Akihiko Shimada and Ikumi Otsuka, Sustainable Environment Studies, Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan)

Chapter 5
Tryptophan Molecule Fragmentation in Collisions with Low-Energy Electrons
(A. V. Snegursky, J. Tamuliene, L. G. Romanova, V. S. Vukstich and A. V. Papp, Institute of Electron Physics, Ukrainian National Academy of Sciences, Uzhgorod, Ukraine, and others)

A Novel Tryptophan-Selective Amino Acid Transporter that is Functionally Coupled to IDO1-Dependent Signaling Pathways
(Yangzom D. Bhutia and Vadivel Ganapathy, Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA)



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