New Developments in Terpenes Research

Jinnan Hu, PhD (Editor)
Department of Plant Pathology, The Ohio State University, Columbus, Ohio, USA

Series: Chemistry Research and Applications
BISAC: SCI013000




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Many of the terpenes compounds are naturally occurring organic products abundant in plants, which have been employed for centuries as odorants because of their aromatic qualities. In the last decades, their valuable properties have attracted growing interest in the pharmaceutical area. In fact, a large number of the world’s population uses plant extracts or their active compounds for health related purposes. Due to the continuous research efforts on terpenes compounds, numerous advances have been made in many aspects including advanced extraction and processing approaches, molecule structure analysis, usage for flavor enrichment, and most importantly, its potential pharmaceutical applications.

This book manages to cover many such recent developments. The potential of some monoterpenes has been reviewed for their use as substrates to obtain new natural flavor compounds with economic and commercial interest. The potential medicine functions of terpenes have been thoroughly discussed in four chapters, including the current knowledge on the antitumor potential of diterpenes in relevant cancers; the application of rosemary extracts as cancer therapy which contain a high concentration of phenolic diterpenes; the possible development of an effective immunotherapy for cancer originated from triterpene compounds such as ursolic acid; and the promising antibacterial, antioxidant, phytotoxic, insecticidal activities of essential oils extracted from the leaves and bugs of Syzygium.

After these discussions and reviews on functions, the later chapters change to other interesting topics, such as a review of the development of effective extraction methods with extraction efficiency, as well as the description of recent advances in the environmentally benign oxidative processes where greener oxidants are used. The last two chapters discuss structures of terpenes: firstly, two computational chemistry approaches are introduced which can serve as important tools in predicting molecule structures and elucidate the mechanisms of action. Finally, the structures of two recently reported pentacyclic triterpenes and their pharmacological potential are discussed. (Imprint: Nova)


Chapter 1: Production of Natural Flavor Compounds Using Monoterpenes as Substrates
(Gustavo Molina, Marina G. Pêssoa, Mariana R. Pimentel, Franciele M. Pelissari, Juliano L. Bicas and Gláucia M. Pastore, Laboratory of Bioflavors, Department of Food Science, Faculty of Food Engineering, University of Campinas, Campinas - SP, Brazil)

Chapter 2: Diterpenes as Cancer Therapy
(Elena González-Burgos and M. Pilar Gómez-Serranillos, Department of Pharmacology, Faculty of Pharmacy, University Complutense Of Madrid, Madrid, Spain)

Chapter 3: Phenolic Diterpenes from Rosemary as Enhancement Agents of Usual Chemotherapeutic Drugs for Colorectal Cancer Therapy
(Tiziana Fornari, Ana Ramírez De Molina and Guillermo Reglero, Instituto De Investigación En Ciencias De La Alimentación Cei Uam+Csic.C/Nicolás Cabrera 9, Madrid, Spain and others)

Chapter 4: The Possible Use of Terpene Compounds in DC Immunotherapy against Cancer
(Masao Takei, Akemi Umeyama and Je-Jung Lee, Research Center For Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeonnam, South Korea and others)

Chapter 5: Essential Oil Compositions and In Vitro Biological Activities of Three Szyzgium Species from Nigeria
(Oladipupo A. Lawal, Isiaka A. Ogunwande, Christiana A. Bullem, Olayinka T. Taiwo and Andy R. Opoku, Department Of Chemistry, Lagos State University, Pmb 001 Lasu Post Office, Ojo, Lagos, Nigeria and others)

Chapter 6: From Terpenoids to Amines: A Critical Review
(Arno Behr and Andreas Wintzer, Chair For Technical Chemistry, Technical University of Dortmund, Dortmund, Germany and others)

Chapter 7: Illudane-Type Sesquiterpenes: Challenges and Opportunities for Toxicology and Chemotherapy
(Rui M. Gil Da Costa, Carlos Lopes, Paula A. Oliveira and Margarida M.S.M. Bastos, Laboratório De Engenharia De Processos Do Ambiente E Da Energia (Lepae), Departamento De Engenharia Química Faculdade De Engenharia, Universidade Do Porto (Feup), Rua Dr. Roberto Frias, Porto, Portugal and others)

Chapter 8: Palladium-Catalysed Monoterpenes Oxidation: Environmentally Benign Synthesis of Valuable Oxigenate Derivatives
(Márcio José da Silva, Abiney Lemos Cardoso, Ligia Maria Mendonca Vieira and Danieli Marcolan Carari, Federal University of Viçosa, Chemistry Department, Minas Gerais, Brazil)

Chapter 9: Theoretical Properties of Terpenes and their Relationship with Biological Activities
(S. Andrade-Ochoa, A.A Camacho-Dávila, L.M. Rodríguez-Valdez, M. Villanueva-García and G.V. Nevárez-Moorillón, Facultad De Ciencias Químicas, Universidad Autónoma De Chihuahua. Chihuahua, México and others)

Chapter 10: Configurational and Conformational Analyses by Theoretical Methods of Pentacyclic Triterpenes Isolated from Myricaria elegans
(A.G. Pacheco, G. Salgado-Morán and A.F.C. Alcântara, Instituto Federal De Educação, Ciência E Tecnologia Do Sul De Minas Gerais, Cep 37576-000, Inconfidentes – MG, Brazil and others)

Chapter 11: Applications and Advances in the Extraction and Analysis of Monoterpenes and Sesquiterpenes in Plants
(J. Omar, M. Olivares, A. Vallejo, S. Delgado, P. Navarro, O. Aizpurua and N. Etxebarria, Department of Analytical Chemistry, and General Service of Analysis (Sgiker), University of the Basque Country (Upv/Ehu), Bilbao, Spain)


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